Q9K907 (PRPE_BACHD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase prpE [asymmetrical]
EC=3.6.1.17

Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase
Short name=Diadenosine tetraphosphatase

Gene names

Name:	prpE
Ordered Locus Names:	BH2845

Organism

Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]

Taxonomic identifier

272558 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Asymmetrically hydrolyzes Ap4p to yield AMP and ATP By similarity. HAMAP MF_01443
Catalytic activity	P1,P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP. HAMAP MF_01443
Cofactor	Nickel By similarity. HAMAP MF_01443
Sequence similarities	Belongs to the prpE family.

Ontologies

Keywords
Ligand	GTP-binding Nickel Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity Inferred from electronic annotation. Source: EC nickel cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Bis(5'-nucleosyl)-tetraphosphatase prpE [asymmetrical] HAMAP MF_01443		PRO_0000297699

Sequences

	Sequence		Length	Mass (Da)
	Q9K907 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: D7BDDDDF35D8EC0E	FASTA	246	28,191
	10 20 30 40 50 60 MQFDIIGDVH GCYDELMELI DKLGYEYKRG SYDHPDGRLL AFVGDLTDRG PHSLEVIRLV 70 80 90 100 110 120 SHMVKKKTAY YVPGNHCNKL YRYMIGRKVQ VKHGLETTVA ELNALSEEER IEVIAQFKEL 130 140 150 160 170 180 YEQAPLYHSF PEDKLVITHA GIREDDIGSY GKRVETFVLY GDITGETNPD GTPVRRDWAA 190 200 210 220 230 240 TYQGDWWIVY GHTPVRRPRI IHRTVNIDTG CVFGGALTAL RFPEIEFVSI PSRQPLVSEK FRNFPG

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000004 Genomic DNA. Translation: BAB06564.1.
PIR	E84005.
RefSeq	NP_243711.1. NC_002570.2.
3D structure databases
ProteinModelPortal	Q9K907.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000052785; EBBACP00000051424; EBBACG00000052776.
GeneID	893255.
GenomeReviews	Gene locus BH2845 in contig BA000004_GR.
KEGG	bha:BH2845.
NMPDR	fig|272558.1.peg.2845.
PATRIC	18942912. VBIBacHal18977_2957.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000002430.
HOGENOM	HBG724457.
OMA	YVPGNHC.
PhylomeDB	Q9K907.
Enzyme and pathway databases
BioCyc	BHAL272558:BH2845-MONOMER.
Family and domain databases
HAMAP	MF_01443. PrpE. [Tree]
InterPro	IPR023937. Bis(5'-nucleosyl)-tetraP_PrpE. IPR004843. Metallo_PEstase_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
KO	K01525.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PRINTS	PR00114. STPHPHTASE.
ProtoNet	Search...

Entry information

Entry name

PRPE_BACHD

Accession

Primary (citable) accession number: Q9K907

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program