Reviewed, UniProtKB/Swiss-Prot Q9K8V2 (ARGC_BACHD)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	BH2900

Organism

Bacillus halodurans [Complete proteome] [HAMAP]

Taxonomic identifier

86665 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_0000112380
Sites
	Active site	149	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9K8V2-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 3E9F45DD09FC68EA	FASTA	345	38,188
	10 20 30 40 50 60 MKVGIVGATG YGGLELIRLL SQHPNVEEII CYSSSQEGLP LDDMYPHLSG NVRWTLKAID 70 80 90 100 110 120 PEAIRADVDT VFLATPPGVS GELTPDLVKL GLKVIDLSGD LRINEPDVYE AWYKRQAAPV 130 140 150 160 170 180 GTIRGAVYGL TEWQRDEIAA AQIIANPGCY PTAVLLGLAP LVQQKWIDPK RIIIDAKSGT 190 200 210 220 230 240 SGAGRNPSQI THFSEMNENF KIYQVNQHKH TPEIEQQLRN WDESVGNVTF STHLVPMVRG 250 260 270 280 290 300 IMATIYAEAN QAISEKELRE HFAYVYETSP FVHVYSEGRY PATKEVFGSN RCHIGVTYDE 310 320 330 340 RTNRITVVSV IDNLVKGAAG QAIQNYNVMN GYEETLGLEG SPLYP

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000004 Genomic DNA. Translation: BAB06619.1.
PIR	D84012.
RefSeq	NP_243766.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	893099.
GenomeReviews	Gene locus BH2900 in contig BA000004_GR.
KEGG	bha:BH2900.
NMPDR	fig|272558.1.peg.2900.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9K8V2.
OMA	VCRIAVH.
Enzyme and pathway databases
BioCyc	BHAL272558:BH2900-MON.
BRENDA	1.2.1.38. 191865.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_BACHD

Accession

Primary (citable) accession number: Q9K8V2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	October 1, 2000
Last modified:	November 3, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)