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Protein

Protein ArsC

Gene

arsC

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.UniRule annotation

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10Nucleophile; for reductase activity and phosphatase activityUniRule annotation1
Active sitei82Nucleophile; for reductase activityUniRule annotation1
Active sitei89Nucleophile; for reductase activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Oxidoreductase

Keywords - Biological processi

Arsenical resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ArsCUniRule annotation
Alternative name(s):
Arsenate reductaseUniRule annotation (EC:1.20.4.-UniRule annotation)
Arsenical pump modifierUniRule annotation
Low molecular weight protein-tyrosine-phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:arsCUniRule annotation
Ordered Locus Names:BH2998
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001625171 – 139Protein ArsCAdd BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi10 ↔ 82Redox-active; alternateUniRule annotation
Disulfide bondi82 ↔ 89Redox-active; alternateUniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272558.BH2998.

Structurei

3D structure databases

ProteinModelPortaliQ9K8K8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4108UXE. Bacteria.
COG0394. LUCA.
HOGENOMiHOG000273093.
KOiK03741.
OMAiHYNFPDP.
OrthoDBiPOG091H07DS.

Family and domain databases

CDDicd00115. LMWPc. 1 hit.
HAMAPiMF_01624. Arsenate_reduct. 1 hit.
InterProiIPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
[Graphical view]
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9K8K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKVIYFLC TGNSCRSQMA EGWGKKYLGD EWDVYSAGIE AHGVNPNAVK
60 70 80 90 100
AMKEIGIDIS EQTSDTIDQE LLQKADLVVT LCGHAADVCP ATPSNKERVH
110 120 130
WGFDDPAKAE GTDEEKWAVF RRVRDEIGKR IKTFAETGK
Length:139
Mass (Da):15,464
Last modified:October 1, 2000 - v1
Checksum:i947770F370847DEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB06717.1.
PIRiF84024.
RefSeqiWP_010899142.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB06717; BAB06717; BAB06717.
KEGGibha:BH2998.
PATRICi18943236. VBIBacHal18977_3119.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB06717.1.
PIRiF84024.
RefSeqiWP_010899142.1. NC_002570.2.

3D structure databases

ProteinModelPortaliQ9K8K8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH2998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB06717; BAB06717; BAB06717.
KEGGibha:BH2998.
PATRICi18943236. VBIBacHal18977_3119.

Phylogenomic databases

eggNOGiENOG4108UXE. Bacteria.
COG0394. LUCA.
HOGENOMiHOG000273093.
KOiK03741.
OMAiHYNFPDP.
OrthoDBiPOG091H07DS.

Family and domain databases

CDDicd00115. LMWPc. 1 hit.
HAMAPiMF_01624. Arsenate_reduct. 1 hit.
InterProiIPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
[Graphical view]
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARSC_BACHD
AccessioniPrimary (citable) accession number: Q9K8K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.