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Protein

Molybdopterin synthase catalytic subunit

Gene

moaE

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity).By similarity

Catalytic activityi

Cyclic pyranopterin phosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein].

Pathwayi: molybdopterin biosynthesis

This protein is involved in the pathway molybdopterin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway molybdopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461SubstrateBy similarity
Binding sitei118 – 1181SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Molybdenum cofactor biosynthesis

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-3116-MONOMER.
UniPathwayiUPA00344.

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdopterin synthase catalytic subunit (EC:2.8.1.12)
Alternative name(s):
MPT synthase subunit 2
Molybdenum cofactor biosynthesis protein E
Molybdopterin-converting factor large subunit
Molybdopterin-converting factor subunit 2
Gene namesi
Name:moaE
Ordered Locus Names:BH3019
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 156156Molybdopterin synthase catalytic subunitPRO_0000163077Add
BLAST

Interactioni

Subunit structurei

Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis (By similarity).By similarity

Protein-protein interaction databases

STRINGi272558.BH3019.

Structurei

3D structure databases

ProteinModelPortaliQ9K8I7.
SMRiQ9K8I7. Positions 3-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni36 – 383Substrate bindingBy similarity
Regioni102 – 1032Substrate bindingBy similarity
Regioni125 – 1273Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the MoaE family.Curated

Phylogenomic databases

eggNOGiENOG4108ZAF. Bacteria.
COG0314. LUCA.
HOGENOMiHOG000280877.
KOiK03635.
OMAiIRSAVYH.
OrthoDBiPOG091H0631.

Family and domain databases

CDDicd00756. MoaE. 1 hit.
Gene3Di3.90.1170.40. 1 hit.
InterProiIPR003448. Mopterin_biosynth_MoaE.
[Graphical view]
PfamiPF02391. MoaE. 1 hit.
[Graphical view]
SUPFAMiSSF54690. SSF54690. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9K8I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKRFAIME QPIVIQQVID QVVHPHAGAI NTFIGTVREL TKGKRTLYLQ
60 70 80 90 100
YEAYPSMAEK KLAQIGQEIQ ERWPEARVAI THRIGRLEIT DVAVVIAVST
110 120 130 140 150
PHRADSYEAS RYAIERIKEI VPIWKKEHWE DGEMWVGDQL ETTSYPEGAP

KMEEEE
Length:156
Mass (Da):17,959
Last modified:October 1, 2000 - v1
Checksum:iD5E9947AAD20948E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB06738.1.
PIRiC84027.
RefSeqiWP_010899163.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB06738; BAB06738; BAB06738.
KEGGibha:BH3019.
PATRICi18943276. VBIBacHal18977_3139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB06738.1.
PIRiC84027.
RefSeqiWP_010899163.1. NC_002570.2.

3D structure databases

ProteinModelPortaliQ9K8I7.
SMRiQ9K8I7. Positions 3-138.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH3019.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB06738; BAB06738; BAB06738.
KEGGibha:BH3019.
PATRICi18943276. VBIBacHal18977_3139.

Phylogenomic databases

eggNOGiENOG4108ZAF. Bacteria.
COG0314. LUCA.
HOGENOMiHOG000280877.
KOiK03635.
OMAiIRSAVYH.
OrthoDBiPOG091H0631.

Enzyme and pathway databases

UniPathwayiUPA00344.
BioCyciBHAL272558:GJC5-3116-MONOMER.

Family and domain databases

CDDicd00756. MoaE. 1 hit.
Gene3Di3.90.1170.40. 1 hit.
InterProiIPR003448. Mopterin_biosynth_MoaE.
[Graphical view]
PfamiPF02391. MoaE. 1 hit.
[Graphical view]
SUPFAMiSSF54690. SSF54690. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMOAE_BACHD
AccessioniPrimary (citable) accession number: Q9K8I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.