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Q9K8G2

- HEM2_BACHD

UniProt

Q9K8G2 - HEM2_BACHD

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Protein

Delta-aminolevulinic acid dehydratase

Gene
hemB, BH3044
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen By similarity.

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.

Cofactori

Binds 1 zinc ion per monomer By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi122 – 1221Zinc; catalytic By similarity
Metal bindingi124 – 1241Zinc; catalytic By similarity
Metal bindingi132 – 1321Zinc; catalytic By similarity
Active sitei197 – 1971Schiff-base intermediate with substrate By similarity
Binding sitei207 – 2071Substrate 1 By similarity
Binding sitei219 – 2191Substrate 1 By similarity
Metal bindingi235 – 2351Magnesium By similarity
Active sitei250 – 2501Schiff-base intermediate with substrate By similarity
Binding sitei276 – 2761Substrate 2 By similarity
Binding sitei315 – 3151Substrate 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. porphobilinogen synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-3141-MONOMER.
UniPathwayiUPA00251; UER00318.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydratase (EC:4.2.1.24)
Short name:
ALAD
Short name:
ALADH
Alternative name(s):
Porphobilinogen synthase
Gene namesi
Name:hemB
Ordered Locus Names:BH3044
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001258: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Delta-aminolevulinic acid dehydratasePRO_0000140492Add
BLAST

Interactioni

Subunit structurei

Homooctamer By similarity.

Protein-protein interaction databases

STRINGi272558.BH3044.

Structurei

3D structure databases

ProteinModelPortaliQ9K8G2.
SMRiQ9K8G2. Positions 7-322.

Family & Domainsi

Sequence similaritiesi

Belongs to the ALADH family.

Phylogenomic databases

eggNOGiCOG0113.
HOGENOMiHOG000020323.
KOiK01698.
OMAiDMILTYF.
OrthoDBiEOG6VXFCB.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9K8G2-1 [UniParc]FASTAAdd to Basket

« Hide

MGQDLTFKRH RRLRQTAAIR NMVRETKLHI DDLIYPIFVK EGEGVRQEVP    50
SMPNVYQLSL DQLDAEVDEI VSLGIPAIIL FGVPAEKDAV GSAAYHEHGI 100
VQQAIRQVKE SYPDLTVIAD TCLCQFTDHG HCGVIEEGKI LNDPSLDLLA 150
RTAVSQAKAG ADIIAPSNMM DGFVAAIRAG LDSAGFTDVP VMSYAVKYAS 200
AFYGPFRDAA HSSPVFGDRK TYQMDPANRL EALREARSDV EEGADFLIVK 250
PALSYLDIIR EVKNETGLPV VAYNVSGEYS MIKAASLQGW IDEKSTVLEK 300
LISMKRAGAD LILTYFAKDV ARWLNEEK 328
Length:328
Mass (Da):36,166
Last modified:October 1, 2000 - v1
Checksum:i74BDEEE1C95B1646
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000004 Genomic DNA. Translation: BAB06763.1.
PIRiD84030.
RefSeqiNP_243910.1. NC_002570.2.
WP_010899188.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB06763; BAB06763; BAB06763.
GeneIDi890913.
KEGGibha:BH3044.
PATRICi18943328. VBIBacHal18977_3165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000004 Genomic DNA. Translation: BAB06763.1 .
PIRi D84030.
RefSeqi NP_243910.1. NC_002570.2.
WP_010899188.1. NC_002570.2.

3D structure databases

ProteinModelPortali Q9K8G2.
SMRi Q9K8G2. Positions 7-322.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272558.BH3044.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB06763 ; BAB06763 ; BAB06763 .
GeneIDi 890913.
KEGGi bha:BH3044.
PATRICi 18943328. VBIBacHal18977_3165.

Phylogenomic databases

eggNOGi COG0113.
HOGENOMi HOG000020323.
KOi K01698.
OMAi DMILTYF.
OrthoDBi EOG6VXFCB.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00318 .
BioCyci BHAL272558:GJC5-3141-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view ]
PANTHERi PTHR11458. PTHR11458. 1 hit.
Pfami PF00490. ALAD. 1 hit.
[Graphical view ]
PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
PRINTSi PR00144. DALDHYDRTASE.
SMARTi SM01004. ALAD. 1 hit.
[Graphical view ]
PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
    Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
    Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Entry informationi

Entry nameiHEM2_BACHD
AccessioniPrimary (citable) accession number: Q9K8G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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