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Q9K8G2

- HEM2_BACHD

UniProt

Q9K8G2 - HEM2_BACHD

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Protein

Delta-aminolevulinic acid dehydratase

Gene

hemB

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).By similarity

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.

Cofactori

Binds 1 zinc ion per monomer.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi122 – 1221Zinc; catalyticBy similarity
Metal bindingi124 – 1241Zinc; catalyticBy similarity
Metal bindingi132 – 1321Zinc; catalyticBy similarity
Active sitei197 – 1971Schiff-base intermediate with substrateBy similarity
Binding sitei207 – 2071Substrate 1By similarity
Binding sitei219 – 2191Substrate 1By similarity
Metal bindingi235 – 2351MagnesiumBy similarity
Active sitei250 – 2501Schiff-base intermediate with substrateBy similarity
Binding sitei276 – 2761Substrate 2By similarity
Binding sitei315 – 3151Substrate 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. porphobilinogen synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-3141-MONOMER.
UniPathwayiUPA00251; UER00318.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydratase (EC:4.2.1.24)
Short name:
ALAD
Short name:
ALADH
Alternative name(s):
Porphobilinogen synthase
Gene namesi
Name:hemB
Ordered Locus Names:BH3044
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001258: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Delta-aminolevulinic acid dehydratasePRO_0000140492Add
BLAST

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

STRINGi272558.BH3044.

Structurei

3D structure databases

ProteinModelPortaliQ9K8G2.
SMRiQ9K8G2. Positions 7-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ALAD family.Curated

Phylogenomic databases

eggNOGiCOG0113.
HOGENOMiHOG000020323.
KOiK01698.
OMAiDMILTYF.
OrthoDBiEOG6VXFCB.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9K8G2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGQDLTFKRH RRLRQTAAIR NMVRETKLHI DDLIYPIFVK EGEGVRQEVP
60 70 80 90 100
SMPNVYQLSL DQLDAEVDEI VSLGIPAIIL FGVPAEKDAV GSAAYHEHGI
110 120 130 140 150
VQQAIRQVKE SYPDLTVIAD TCLCQFTDHG HCGVIEEGKI LNDPSLDLLA
160 170 180 190 200
RTAVSQAKAG ADIIAPSNMM DGFVAAIRAG LDSAGFTDVP VMSYAVKYAS
210 220 230 240 250
AFYGPFRDAA HSSPVFGDRK TYQMDPANRL EALREARSDV EEGADFLIVK
260 270 280 290 300
PALSYLDIIR EVKNETGLPV VAYNVSGEYS MIKAASLQGW IDEKSTVLEK
310 320
LISMKRAGAD LILTYFAKDV ARWLNEEK
Length:328
Mass (Da):36,166
Last modified:October 1, 2000 - v1
Checksum:i74BDEEE1C95B1646
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000004 Genomic DNA. Translation: BAB06763.1.
PIRiD84030.
RefSeqiNP_243910.1. NC_002570.2.
WP_010899188.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB06763; BAB06763; BAB06763.
GeneIDi890913.
KEGGibha:BH3044.
PATRICi18943328. VBIBacHal18977_3165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000004 Genomic DNA. Translation: BAB06763.1 .
PIRi D84030.
RefSeqi NP_243910.1. NC_002570.2.
WP_010899188.1. NC_002570.2.

3D structure databases

ProteinModelPortali Q9K8G2.
SMRi Q9K8G2. Positions 7-322.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272558.BH3044.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB06763 ; BAB06763 ; BAB06763 .
GeneIDi 890913.
KEGGi bha:BH3044.
PATRICi 18943328. VBIBacHal18977_3165.

Phylogenomic databases

eggNOGi COG0113.
HOGENOMi HOG000020323.
KOi K01698.
OMAi DMILTYF.
OrthoDBi EOG6VXFCB.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00318 .
BioCyci BHAL272558:GJC5-3141-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view ]
PANTHERi PTHR11458. PTHR11458. 1 hit.
Pfami PF00490. ALAD. 1 hit.
[Graphical view ]
PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
PRINTSi PR00144. DALDHYDRTASE.
SMARTi SM01004. ALAD. 1 hit.
[Graphical view ]
PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
    Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
    Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Entry informationi

Entry nameiHEM2_BACHD
AccessioniPrimary (citable) accession number: Q9K8G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3