Reviewed, UniProtKB/Swiss-Prot Q9K8D9 (NTPA2_BACHD)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase 2
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase 2
      Short name=NTPase 2

Gene names

Ordered Locus Names:

BH3067

Organism

Bacillus halodurans [Complete proteome] [HAMAP]

Taxonomic identifier

86665 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405
Catalytic activity	NTP + H2O = NDP + phosphate. HAMAP MF_01405
Cofactor	Divalent cations By similarity. HAMAP MF_01405
Subunit structure	Homodimer By similarity. HAMAP MF_01405
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	Nucleoside-triphosphatase 2 HAMAP MF_01405		PRO_0000178125

Sequences

	Sequence		Length	Mass (Da)
	Q9K8D9-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: BBC5A0C4F19A04B3	FASTA	194	21,868
	10 20 30 40 50 60 MKEWIVATKN KGKVAEFEAI LGKRGFSVKS LLDYPAIEDI EETGSTFNEN ATIKAEAIAE 70 80 90 100 110 120 RFQRPVLADD SGLIIDALDG RPGIFSARYA GEEKDDQKNI EKVLRELQDI PWKARTARFH 130 140 150 160 170 180 CSIALARPQA ETIVFEGTCE GYITTEPKGT GGFGYDPIFY VPSHDKTMAE LTQEEKNKLS 190 HRYHALKQLD KWLD

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000004 Genomic DNA. Translation: BAB06786.1.
PIR	C84033.
RefSeq	NP_243933.1.
3D structure databases
SMR	Q9K8D9. Positions 1-194.
ModBase	Search...
Genome annotation databases
GeneID	890587.
GenomeReviews	Gene locus BH3067 in contig BA000004_GR.
KEGG	bha:BH3067.
NMPDR	fig|272558.1.peg.3067.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG697237.
OMA	VYTADWA.
PhylomeDB	Q9K8D9.
Enzyme and pathway databases
BioCyc	BHAL272558:BH3067-MONOMER.
BRENDA	3.6.1.15. 191865.
Family and domain databases
HAMAP	MF_01405. Nucleoside_triphosp. [Tree]
InterPro	IPR002637. Ham1p-like. IPR020922. Nucleoside-triphosphatase. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA2_BACHD

Accession

Primary (citable) accession number: Q9K8D9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	October 1, 2000
Last modified:	February 9, 2010
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)