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Q9K848

- Q9K848_BACHD

UniProt

Q9K848 - Q9K848_BACHD

Protein

Isocitrate dehydrogenase [NADP]

Gene

citC

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation
    Binds 1 magnesium or manganese ion per subunit By similarity.

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciBHAL272558:GJC5-3258-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:citCImported
    Ordered Locus Names:BH3159Imported
    OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)Imported
    Taxonomic identifieri272558 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001258: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi272558.BH3159.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9K848.
    SMRiQ9K848. Positions 1-422.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiCLRPIRY.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9K848-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANGEKIKVS AGVLEVPNNP IIPFIEGDGT GPDIWAAAHR VIDAAVEKAY    50
    NGEKKIVWKE ILAGEKAFNQ TGQWLPDETL ETIREYTIAI KGPLTTPVGG 100
    GIRSLNVALR QELDLYVCLR PVRYFNGVPS PVKRPEDTNM VIFRENSEDI 150
    YAGIEYQAGT DEVKKVINFL REEMGVKKIR FPETSGIGIK PVSQEGTDRL 200
    VRAAIQYAIT EGRKSVTLVH KGNIMKFTEG AFKNWGYEVA EREFGDKVFT 250
    WAQYDKIVEE QGKEAADKAQ AEAEAAGKII VKDSIADIFL QQILTRPKEF 300
    DVVATMNLNG DYISDALAAQ VGGIGIAPGA NINYDTGHAI FEATHGTAPK 350
    YAGLDKVNPS SVLLSGELML RHLGWNEAAD LIMASMDKTI ESKVVTYDFA 400
    RLMDGATEVK CSEFANELIK NL 422
    Length:422
    Mass (Da):46,361
    Last modified:October 1, 2000 - v1
    Checksum:i6FF37DA3417AE722
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000004 Genomic DNA. Translation: BAB06878.1.
    PIRiG84044.
    RefSeqiNP_244025.1. NC_002570.2.

    Genome annotation databases

    EnsemblBacteriaiBAB06878; BAB06878; BAB06878.
    GeneIDi890641.
    KEGGibha:BH3159.
    PATRICi18943574. VBIBacHal18977_3286.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000004 Genomic DNA. Translation: BAB06878.1 .
    PIRi G84044.
    RefSeqi NP_244025.1. NC_002570.2.

    3D structure databases

    ProteinModelPortali Q9K848.
    SMRi Q9K848. Positions 1-422.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272558.BH3159.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB06878 ; BAB06878 ; BAB06878 .
    GeneIDi 890641.
    KEGGi bha:BH3159.
    PATRICi 18943574. VBIBacHal18977_3286.

    Phylogenomic databases

    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi CLRPIRY.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci BHAL272558:GJC5-3258-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
      Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
      Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125Imported.

    Entry informationi

    Entry nameiQ9K848_BACHD
    AccessioniPrimary (citable) accession number: Q9K848
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2000
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3