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Q9K848

- Q9K848_BACHD

UniProt

Q9K848 - Q9K848_BACHD

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Protein
Isocitrate dehydrogenase [NADP]
Gene
citC, BH3159
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-3258-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:citCImported
Ordered Locus Names:BH3159Imported
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)Imported
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001258: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi272558.BH3159.

Structurei

3D structure databases

ProteinModelPortaliQ9K848.
SMRiQ9K848. Positions 1-422.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9K848-1 [UniParc]FASTAAdd to Basket

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MANGEKIKVS AGVLEVPNNP IIPFIEGDGT GPDIWAAAHR VIDAAVEKAY    50
NGEKKIVWKE ILAGEKAFNQ TGQWLPDETL ETIREYTIAI KGPLTTPVGG 100
GIRSLNVALR QELDLYVCLR PVRYFNGVPS PVKRPEDTNM VIFRENSEDI 150
YAGIEYQAGT DEVKKVINFL REEMGVKKIR FPETSGIGIK PVSQEGTDRL 200
VRAAIQYAIT EGRKSVTLVH KGNIMKFTEG AFKNWGYEVA EREFGDKVFT 250
WAQYDKIVEE QGKEAADKAQ AEAEAAGKII VKDSIADIFL QQILTRPKEF 300
DVVATMNLNG DYISDALAAQ VGGIGIAPGA NINYDTGHAI FEATHGTAPK 350
YAGLDKVNPS SVLLSGELML RHLGWNEAAD LIMASMDKTI ESKVVTYDFA 400
RLMDGATEVK CSEFANELIK NL 422
Length:422
Mass (Da):46,361
Last modified:October 1, 2000 - v1
Checksum:i6FF37DA3417AE722
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000004 Genomic DNA. Translation: BAB06878.1.
PIRiG84044.
RefSeqiNP_244025.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB06878; BAB06878; BAB06878.
GeneIDi890641.
KEGGibha:BH3159.
PATRICi18943574. VBIBacHal18977_3286.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000004 Genomic DNA. Translation: BAB06878.1 .
PIRi G84044.
RefSeqi NP_244025.1. NC_002570.2.

3D structure databases

ProteinModelPortali Q9K848.
SMRi Q9K848. Positions 1-422.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272558.BH3159.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB06878 ; BAB06878 ; BAB06878 .
GeneIDi 890641.
KEGGi bha:BH3159.
PATRICi 18943574. VBIBacHal18977_3286.

Phylogenomic databases

HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci BHAL272558:GJC5-3258-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
    Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
    Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Entry informationi

Entry nameiQ9K848_BACHD
AccessioniPrimary (citable) accession number: Q9K848
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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