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Q9K821 (ARLY_BACHD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:BH3186
OrganismBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]
Taxonomic identifier272558 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length458 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 458458Argininosuccinate lyase HAMAP MF_00006
PRO_0000137738

Sequences

Sequence LengthMass (Da)Tools
Q9K821 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: CF8F32B39DFAFC40

FASTA45851,105
        10         20         30         40         50         60 
MTKLWGGRFT KTAEAWVDEF GASIGFDQQL VEEDIEGSLA HVTMLEKSGI LANEEVEQIK 

        70         80         90        100        110        120 
KGLHILLEKA KKGELNYSVA NEDIHLNIEK LLIDEIGPVG GKLHTGRSRN DQVATDMHLY 

       130        140        150        160        170        180 
LRKQTKEILQ LVKNVQAALV EQAKQHVETL IPGYTHLQRA QPISFAHHLL AYFWMLERDY 

       190        200        210        220        230        240 
GRYEDSLKRL NVSPLGAGAL AGTTFPIDRE YTAELLGFDG IYENSLDAVS DRDFIVEFLS 

       250        260        270        280        290        300 
ASSLLMTHLS RLCEELILWS SQEFQFVEMD DAFATGSSIM PQKKNPDMAE LIRGKTGRVY 

       310        320        330        340        350        360 
GSLFSLLTVL KGLPLAYNKD MQEDKEGMFD AVKTVKGSLA IFAGMIQTMK VKEETMTKAV 

       370        380        390        400        410        420 
HQDFSNATEL ADYLATKGMP FREAHEVVGK LVLLCIQKGI YLLDLPLSDY KAASDLFDED 

       430        440        450 
IYDVLQPKTV VARRTSAGGT GFTEVKKAIA KAEKILAN

« Hide

References

[1]"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000004 Genomic DNA. Translation: BAB06905.1.
PIRB84048.
RefSeqNP_244052.1. NC_002570.2.

3D structure databases

ProteinModelPortalQ9K821.
SMRQ9K821. Positions 14-457.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000050592; EBBACP00000049231; EBBACG00000050583.
GeneID890656.
GenomeReviewsGene locus BH3186 in contig BA000004_GR.
KEGGbha:BH3186.
NMPDRfig|272558.1.peg.3186.
PATRIC18943636. VBIBacHal18977_3317.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00070000031828.
HOGENOMHBG539632.
OMAEDIHTVI.
PhylomeDBQ9K821.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycBHAL272558:BH3186-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_BACHD
AccessionPrimary (citable) accession number: Q9K821
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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