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Q9K7S8

- SYL_BACHD

UniProt

Q9K7S8 - SYL_BACHD

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-3380-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BH3281
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001258: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 806806Leucine--tRNA ligasePRO_0000151969Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272558.BH3281.

Structurei

3D structure databases

ProteinModelPortaliQ9K7S8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi576 – 5805"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9K7S8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFSHREIES KWQKYWEENK TFKTEEDETR EKFYALDMFP YPSGAGLHVG
60 70 80 90 100
HPEGYTATDI LSRMKRMQGY NVLHPMGWDA FGLPAEQYAI DTGNSPAEFT
110 120 130 140 150
EKNINTFRRQ IKSLGFSYDW DREVNTTDPD YYKWTQWIFI QLYNKGLAYI
160 170 180 190 200
DEVAVNWCPA LGTVLANEEV IDGKSERGGH PVERRPMKQW MLKITEYADR
210 220 230 240 250
LLEDLEELDW PESIKDMQRN WIGRSEGAEV TFSVDGHDDT ITVFTTRPDT
260 270 280 290 300
LFGATYMVLA PEHKLVDAIT TSEQKQAVES YKKEVATKSD LERTELAKEK
310 320 330 340 350
TGVFTGAYAI NPVNGEKVPI WIADYVLVSY GTGAIMAVPA HDERDYEFAK
360 370 380 390 400
TFDLPIKEVV SGGVIEQEAY TGDGPHVNSE FLNGLSKEEA IEKMIQWLEA
410 420 430 440 450
EKKGTKKVTY RLRDWLFSRQ RYWGEPIPVI HWEDGTMSTV PEDELPLELP
460 470 480 490 500
KMSEIKPSGT GESPLANATD WLEVVDPVTG KKGRRETNTM PQWAGSCWYY
510 520 530 540 550
LRYIDPDNER MIADPEKLKK WLPVDIYIGG AEHAVLHLLY ARFWHKVLYD
560 570 580 590 600
LGVVPTKEPF QKLYNQGMIL GENNEKMSKS KGNVVNPDDI IDSHGADTLR
610 620 630 640 650
LYEMFMGPLD ASIAWSTTGL DGARRFLDRV WRLLVDENTE EKSSKIVNGE
660 670 680 690 700
GSPELKRAYH QTVKKVTEDF EELRFNVGIS QLMVYVNEAY KQEELPLDQA
710 720 730 740 750
EGFVKLLSPV APHLAEELWS KLGHEGTIAY EPWPTYDEAF LVEDEVEIVV
760 770 780 790 800
QHNGKVRAKV VVAKDATKEQ MEEAALANER VKESIDGKTV RKVIVVPGKL

VNIVAN
Length:806
Mass (Da):92,066
Last modified:October 1, 2000 - v1
Checksum:iC019DA99B555F479
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000004 Genomic DNA. Translation: BAB07000.1.
PIRiA84060.
RefSeqiNP_244147.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB07000; BAB07000; BAB07000.
GeneIDi891254.
KEGGibha:BH3281.
PATRICi18943836. VBIBacHal18977_3417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000004 Genomic DNA. Translation: BAB07000.1 .
PIRi A84060.
RefSeqi NP_244147.1. NC_002570.2.

3D structure databases

ProteinModelPortali Q9K7S8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272558.BH3281.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB07000 ; BAB07000 ; BAB07000 .
GeneIDi 891254.
KEGGi bha:BH3281.
PATRICi 18943836. VBIBacHal18977_3417.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BHAL272558:GJC5-3380-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
    Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
    Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Entry informationi

Entry nameiSYL_BACHD
AccessioniPrimary (citable) accession number: Q9K7S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3