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Q9K7L8 (G6PI_BACHD) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:BH3343
OrganismBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]
Taxonomic identifier272558 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180589

Sites

Active site2911Proton donor By similarity
Active site3121 By similarity
Active site4261 By similarity

Amino acid modifications

Modified residue391Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9K7L8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 266C4B7E757609D8

FASTA45050,429
        10         20         30         40         50         60 
MSGKVCFDYS KALDFIQEHE LDNLQDQVHA AHRALHDGTG AGNDFLGWID LPVNYDREEF 

        70         80         90        100        110        120 
SRIQKAAEKI RNDSDVLLVI GIGGSYLGAK ATLEALNHSF YNIVDKSERK GPQIFFVGHH 

       130        140        150        160        170        180 
ISSTYVQELF DVLEGKDVSI NVISKSGTTT EPAIAFRIFR DYLEKKYGKE ESRKRIYATT 

       190        200        210        220        230        240 
DRERGALKTL ANEEGYESFI IPDDVGGRFS VLTAVGLLPI AASGLDIEAM MKGAADARDA 

       250        260        270        280        290        300 
FRNSDLKENP AYQYAVVRNA LYNKGKTIEL MVNYEPALQY FSEWWKQLYG ESEGKDGKGI 

       310        320        330        340        350        360 
FPASVNFSTD LHSMGQYVQD GRRDLFETII QVEKPKKNMT IEKADQDLDG LNYLAGETMD 

       370        380        390        400        410        420 
FVNKKAFEGT LLAHVDGGVP NLVVSVPELD EYYMGYLMYF FEKACGLSGY LLGVNPFDQP 

       430        440        450 
GVEAYKKNMF ALLGKPGFEE QKAALEKRLK 

« Hide

References

[1]"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000004 Genomic DNA. Translation: BAB07062.1.
PIRG84067.
RefSeqNP_244209.1. NC_002570.2.

3D structure databases

ProteinModelPortalQ9K7L8.
SMRQ9K7L8. Positions 5-449.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272558.BH3343.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB07062; BAB07062; BAB07062.
GeneID891275.
KEGGbha:BH3343.
PATRIC18943960. VBIBacHal18977_3478.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000100403.
KOK01810.
OMAQVIFIGN.
OrthoDBEOG64R61J.

Enzyme and pathway databases

BioCycBHAL272558:GJC5-3443-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_BACHD
AccessionPrimary (citable) accession number: Q9K7L8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways