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Q9K7L2 (THIM_BACHD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Synonyms:thiK
Ordered Locus Names:BH3349
OrganismBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]
Taxonomic identifier272558 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000156926

Sites

Binding site381Substrate; via amide nitrogen By similarity
Binding site1141ATP By similarity
Binding site1591ATP By similarity
Binding site1861Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9K7L2 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 49FDA1AB0C7425F6

FASTA26127,064
        10         20         30         40         50         60 
MSIEMLRKSN PLIHCMTNVV VTNFTANGLL AVGASPVMAY AKEEVADMAK VANALLLNIG 

        70         80         90        100        110        120 
TLSAESIDNM IIAGKAANKA GAPVVLDPVG AGATVFRTES CKRILKEVDV TIVRGNGGEI 

       130        140        150        160        170        180 
AALSDQAGTV KGVDGSIDSD PVELAKHAAN VLNSAVVVTG EVDVVTDGTG TVCGYNGHPW 

       190        200        210        220        230        240 
LTKVVGTGCL SGAIVAAFAS LKTDDFLEVI GYGLVAYGVA AEKAYEETKA KGYGSFQTAF 

       250        260 
LNQLGRLTDE DVKQHGRFER S 

« Hide

References

[1]"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000004 Genomic DNA. Translation: BAB07068.1.
PIRE84068.
RefSeqNP_244215.1. NC_002570.2.

3D structure databases

ProteinModelPortalQ9K7L2.
SMRQ9K7L2. Positions 3-260.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272558.BH3349.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB07068; BAB07068; BAB07068.
GeneID891270.
KEGGbha:BH3349.
PATRIC18943972. VBIBacHal18977_3484.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMASPVMAHA.
OrthoDBEOG628F8M.
ProtClustDBPRK09355.

Enzyme and pathway databases

BioCycBHAL272558:GJC5-3449-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_BACHD
AccessionPrimary (citable) accession number: Q9K7L2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: February 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways