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Protein

Probable adenylyl-sulfate kinase

Gene

BH3385

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of activated sulfate.By similarity

Catalytic activityi

ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate.

Pathwayi: hydrogen sulfide biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes sulfite from sulfate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Sulfate adenylyltransferase (sat), Sulfate adenylyltransferase (sat)
  2. Probable adenylyl-sulfate kinase (BH1489), Probable adenylyl-sulfate kinase (BH3385)
  3. Phosphoadenosine phosphosulfate reductase (cysH)
This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei112 – 1121Phosphoserine intermediateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 458ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-3486-MONOMER.
UniPathwayiUPA00140; UER00205.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable adenylyl-sulfate kinase (EC:2.7.1.25)
Alternative name(s):
APS kinase
ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
Adenosine-5'-phosphosulfate kinase
Gene namesi
Ordered Locus Names:BH3385
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Probable adenylyl-sulfate kinasePRO_0000105902Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272558.BH3385.

Structurei

3D structure databases

ProteinModelPortaliQ9K7H6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the APS kinase family.Curated

Phylogenomic databases

eggNOGiENOG4108I67. Bacteria.
COG0529. LUCA.
HOGENOMiHOG000228204.
KOiK00860.
OMAiPARAFWF.
OrthoDBiPOG091H04O4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00065. Adenylyl_sulf_kinase. 1 hit.
InterProiIPR002891. APS_kinase.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00455. apsK. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9K7H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSNSQDAAS IVWHPQLVTK QARNQSNGHK SRMIWFTGLS GSGKSTIANA
60 70 80 90 100
VQAELFKRGI QVYVLDGDNL RHGLNADLSF SMEDRKENIR RTAEVGKLFV
110 120 130 140 150
DAGLVVLAAL ISPVEEERQR ARSRFAEDEF LEVYVSCTLQ ECEKRDPKGL
160 170 180 190 200
YKKARKGEIP QFTGIHQPYE EPKNPDICID TTDRTVEQSV QIILPIILEK

IAWKEGEQ
Length:208
Mass (Da):23,528
Last modified:October 1, 2000 - v1
Checksum:i6BAA228A1F6BC3BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB07104.1.
PIRiA84073.
RefSeqiWP_010899526.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB07104; BAB07104; BAB07104.
KEGGibha:BH3385.
PATRICi18944042. VBIBacHal18977_3519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB07104.1.
PIRiA84073.
RefSeqiWP_010899526.1. NC_002570.2.

3D structure databases

ProteinModelPortaliQ9K7H6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH3385.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB07104; BAB07104; BAB07104.
KEGGibha:BH3385.
PATRICi18944042. VBIBacHal18977_3519.

Phylogenomic databases

eggNOGiENOG4108I67. Bacteria.
COG0529. LUCA.
HOGENOMiHOG000228204.
KOiK00860.
OMAiPARAFWF.
OrthoDBiPOG091H04O4.

Enzyme and pathway databases

UniPathwayiUPA00140; UER00205.
BioCyciBHAL272558:GJC5-3486-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00065. Adenylyl_sulf_kinase. 1 hit.
InterProiIPR002891. APS_kinase.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00455. apsK. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCYSC2_BACHD
AccessioniPrimary (citable) accession number: Q9K7H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.