Reviewed, UniProtKB/Swiss-Prot Q9K7E3 (THRC_BACHD)

Names and origin

Protein names

Recommended name:
    Threonine synthase
    EC=4.2.3.1

Gene names

Name:	thrC
Ordered Locus Names:	BH3421

Organism

Bacillus halodurans [Complete proteome] [HAMAP]

Taxonomic identifier

86665 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	O-phospho-L-homoserine + H2O = L-threonine + phosphate.
Cofactor	Pyridoxal phosphate.
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.
Sequence similarities	Belongs to the serine/threonine dehydratase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro threonine synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Threonine synthase		PRO_0000185624
Amino acid modifications
	Modified residue	61	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9K7E3-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: D25EABAB4952C691	FASTA	354	37,665
	10 20 30 40 50 60 MSQWRGLLQE YKEFLPVTEE TPLLTLGEGN TPLIPLENLS KEWGVKAYVK YEGANPTGSF 70 80 90 100 110 120 KDRGMVMAVA KAKEEGSRTI ICASTGNTSA AAAAYGARAG LRCIVVIPEG KIALGKLAQA 130 140 150 160 170 180 VMYGAEVLEI KGNFDHALDI VRSISEKEPI TLVNSVNPYR IEGQKTSAFE ICDALGQAPD 190 200 210 220 230 240 VLAIPVGNAG NITAYWKGFK EYHEKKGTGL PQMRGFEAEG AAAIVRNQVI EEPETIATAI 250 260 270 280 290 300 RIGNPASWTY AVEAAAESNG KIDEVTDEEI LAAYQLLAQK EGVFAEPASC ASIAGLRKQI 310 320 330 340 350 ASGEIKKGST VVCVLTGNGL KDPNTAMSTI DVNPAVLPND EQAFLDHIKG GVPK

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000004 Genomic DNA. Translation: BAB07140.1.
PIR	E84077.
RefSeq	NP_244288.1.
3D structure databases
HSSP	HSSP built from PDB template 1E5X based on UniProtKB Q9S7B5.
ModBase	Search...
Genome annotation databases
GeneID	894384.
GenomeReviews	Gene locus BH3421 in contig BA000004_GR.
KEGG	bha:BH3421.
NMPDR	fig|272558.1.peg.3421.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9K7E3.
OMA	QVDGNFD.
Enzyme and pathway databases
BioCyc	BHAL272558:BH3421-MON.
BRENDA	4.2.3.1. 191865.
Family and domain databases
InterPro	IPR001926. PyrdxlP-dep_enz_bsu. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. IPR004450. Thr_synthase. [Graphical view]
Pfam	PF00291. PALP. 1 hit. [Graphical view]
TIGRFAMs	TIGR00260. thrC. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THRC_BACHD

Accession

Primary (citable) accession number: Q9K7E3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2001
Last sequence update:	October 1, 2000
Last modified:	November 3, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)