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Protein

Probable cysteine desulfurase

Gene

csd

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.By similarity

Catalytic activityi

L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei361 – 3611Cysteine persulfide intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-3570-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cysteine desulfurase (EC:2.8.1.7)
Gene namesi
Name:csd
Ordered Locus Names:BH3469
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Probable cysteine desulfurasePRO_0000150292Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei224 – 2241N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

STRINGi272558.BH3469.

Structurei

3D structure databases

ProteinModelPortaliQ9K7A0.
SMRiQ9K7A0. Positions 3-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0520. LUCA.
KOiK11717.
OMAiMIDFVGL.
OrthoDBiEOG68DD0M.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR010970. Cys_dSase_SufS.
IPR016454. Cysteine_dSase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF005572. NifS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01979. sufS. 1 hit.
PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9K7A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAHEIKKLF PVLDQEVNGS PLVYLDSAAT SQKPIAVIEA LDDYYRRYNS
60 70 80 90 100
NVHRGVHTLG TLATDGYEGA REKIRRFIHA SSTEEIIFTR GTTTAINLVA
110 120 130 140 150
ASYGRANLGE GDEIVITPME HHSNIIPWQQ VAKATGATLT YLPLQKDGTI
160 170 180 190 200
KIEDVEKTIS EKTKIVAIMH VSNVLGTINP VKEIAEIAHR HGAIMLVDGA
210 220 230 240 250
QSAPHMKIDV QELGCDFFAF SGHKMAGPTG IGVLYGKKAH LEKMEPVEFG
260 270 280 290 300
GEMIDFVGLY DSTWKELPWK FEGGTPIIAG AIGLGAAIDF LEDIGLDEIE
310 320 330 340 350
KHEHELAQYA LDRLSELEGM TVYGPQKRAG LVTFNIEDVH PHDVATVLDA
360 370 380 390 400
DGIAVRAGHH CAQPLMKWLD VTATARASFY LYNTKEDIDA LAKGLEKTKE

YFGHVF
Length:406
Mass (Da):44,632
Last modified:April 27, 2001 - v2
Checksum:i35FB20313CCA24FB
GO

Sequence cautioni

The sequence BAB07188.1 differs from that shown. Reason: Frameshift at position 241. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB07188.1. Frameshift.
PIRiE84083.

Genome annotation databases

EnsemblBacteriaiBAB07188; BAB07188; BAB07188.
KEGGibha:BH3469.
PATRICi18944212. VBIBacHal18977_3604.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB07188.1. Frameshift.
PIRiE84083.

3D structure databases

ProteinModelPortaliQ9K7A0.
SMRiQ9K7A0. Positions 3-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH3469.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB07188; BAB07188; BAB07188.
KEGGibha:BH3469.
PATRICi18944212. VBIBacHal18977_3604.

Phylogenomic databases

eggNOGiCOG0520. LUCA.
KOiK11717.
OMAiMIDFVGL.
OrthoDBiEOG68DD0M.

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-3570-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR010970. Cys_dSase_SufS.
IPR016454. Cysteine_dSase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF005572. NifS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01979. sufS. 1 hit.
PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
    Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
    Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Entry informationi

Entry nameiCSD_BACHD
AccessioniPrimary (citable) accession number: Q9K7A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: January 20, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.