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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

gpmI

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential for rapid growth and for sporulation. Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (pykA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12Manganese 2UniRule annotation1
Active sitei62Phosphoserine intermediateUniRule annotation1
Metal bindingi62Manganese 2UniRule annotation1
Binding sitei123SubstrateUniRule annotation1
Binding sitei185SubstrateUniRule annotation1
Binding sitei191SubstrateUniRule annotation1
Binding sitei336SubstrateUniRule annotation1
Metal bindingi403Manganese 1UniRule annotation1
Metal bindingi407Manganese 1UniRule annotation1
Metal bindingi444Manganese 2UniRule annotation1
Metal bindingi445Manganese 2UniRule annotation1
Metal bindingi462Manganese 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Glycolysis, Sporulation

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.12UniRule annotation)
Short name:
BPG-independent PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
iPGMUniRule annotation
Gene namesi
Name:gpmIUniRule annotation
Synonyms:pgm
Ordered Locus Names:BH3557
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002121241 – 5102,3-bisphosphoglycerate-independent phosphoglycerate mutaseAdd BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphotyrosineUniRule annotation1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272558.BH3557.

Structurei

3D structure databases

ProteinModelPortaliQ9K716.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 154Substrate bindingUniRule annotation2
Regioni261 – 264Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the BPG-independent phosphoglycerate mutase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJI. Bacteria.
COG0696. LUCA.
HOGENOMiHOG000223664.
KOiK15633.
OMAiLHIATMT.
OrthoDBiPOG091H01EL.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9K716-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKPVALII LDGFAMRDEA KGNAVAQANK PNFDRYWNQY PHALLKADGE
60 70 80 90 100
AVGLPEGQMG NSEVGHLNIG AGRIVYQSLT RVNLSIREGE FFENETFLNA
110 120 130 140 150
MNHVKEKGSS LHIYGLVSDG GIHSHINHLY ALLELAKREQ VERVYIHGFL
160 170 180 190 200
DGRDVGPTSA ESYLVDLEAK MKELGVGELA TLHGRYYAMD RDKRWDRVEK
210 220 230 240 250
SYRAMVYGEG PAYSSALDVI KDSYENSIHD EFVIPSVITN EDGSPVATIE
260 270 280 290 300
DDDAIIFFNF RPDRAIQMSQ VFTNKDFRGF DRGEKLPQNV YYVCLTHFSE
310 320 330 340 350
TVQGDVAFKP TNLDNTLGEV LAQQNYKQLR IAETEKYPHV TFFFSGGREE
360 370 380 390 400
PFPGEERILI DSPKVATYDL KPEMSAYEVT DALLNEIEAD KHDVIILNFA
410 420 430 440 450
NPDMVGHSGM LEPTIKAVEA VDECLGKVVD AILAKGGAAV ITADHGNADE
460 470 480 490 500
VVTLEGKPMT AHTTNKVPVI VTEEGLNLRE DGILADLSPT VLDLLGGKQP
510
AEMTGKTLIK
Length:510
Mass (Da):56,454
Last modified:October 1, 2000 - v1
Checksum:i52AF47C6EE03623E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB07276.1.
PIRiE84094.
RefSeqiWP_010899686.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB07276; BAB07276; BAB07276.
KEGGibha:BH3557.
PATRICi18944396. VBIBacHal18977_3696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB07276.1.
PIRiE84094.
RefSeqiWP_010899686.1. NC_002570.2.

3D structure databases

ProteinModelPortaliQ9K716.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH3557.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB07276; BAB07276; BAB07276.
KEGGibha:BH3557.
PATRICi18944396. VBIBacHal18977_3696.

Phylogenomic databases

eggNOGiENOG4105CJI. Bacteria.
COG0696. LUCA.
HOGENOMiHOG000223664.
KOiK15633.
OMAiLHIATMT.
OrthoDBiPOG091H01EL.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGPMI_BACHD
AccessioniPrimary (citable) accession number: Q9K716
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.