Q9K709 (CLPP1_BACHD) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 72.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: ATP-dependent Clp protease proteolytic subunit 1 EC=3.4.21.92 Alternative name(s): Endopeptidase Clp 1 | ||||||
| Gene names |
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| Organism | Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 272558 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 194 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. ClpXP1 is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor By similarity. HAMAP MF_00444 |
| Catalytic activity | Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00444. |
| Sequence similarities | Belongs to the peptidase S14 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Hydrolase Protease Serine protease |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | proteolysis Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 194 | 194 | ATP-dependent Clp protease proteolytic subunit 1 HAMAP MF_00444 | PRO_0000179493 | |||||
Sites | |||||||||
| Active site | 98 | 1 | By similarity | ||||||
| Active site | 123 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BA000004 Genomic DNA. Translation: BAB07283.1. |
| PIR | D84095. |
| RefSeq | NP_244431.1. NC_002570.2. |
3D structure databases | |
| ProteinModelPortal | Q9K709. |
| SMR | Q9K709. Positions 3-190. |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | S14.001. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBBACT00000050759; EBBACP00000049398; EBBACG00000050750. |
| GeneID | 894331. |
| GenomeReviews | Gene locus BH3564 in contig BA000004_GR. |
| KEGG | bha:BH3564. |
| NMPDR | fig|272558.1.peg.3564. |
| PATRIC | 18944410. VBIBacHal18977_3703. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| GeneTree | EBGT00050000002046. |
| HOGENOM | HBG558421. |
| OMA | MEAQDFG. |
| PhylomeDB | Q9K709. |
| ProtClustDB | PRK00277. |
Enzyme and pathway databases | |
| BioCyc | BHAL272558:BH3564-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00444. ClpP. [Tree] |
| InterPro | IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view] |
| KO | K01358. |
| Pfam | PF00574. CLP_protease. 1 hit. [Graphical view] |
| PRINTS | PR00127. CLPPROTEASEP. |
| TIGRFAMs | TIGR00493. ClpP. 1 hit. |
| PROSITE | PS00382. CLP_PROTEASE_HIS. 1 hit. PS00381. CLP_PROTEASE_SER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CLPP1_BACHD | ||||||||
| Accession | Primary (citable) accession number: Q9K709 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

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