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Q9K6Z2

- HISX_BACHD

UniProt

Q9K6Z2 - HISX_BACHD

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei121 – 1211NADUniRule annotation
    Binding sitei183 – 1831NADUniRule annotation
    Binding sitei206 – 2061NADUniRule annotation
    Binding sitei229 – 2291SubstrateUniRule annotation
    Metal bindingi251 – 2511ZincUniRule annotation
    Binding sitei251 – 2511SubstrateUniRule annotation
    Metal bindingi254 – 2541ZincUniRule annotation
    Binding sitei254 – 2541SubstrateUniRule annotation
    Active sitei319 – 3191Proton acceptorUniRule annotation
    Active sitei320 – 3201Proton acceptorUniRule annotation
    Binding sitei320 – 3201SubstrateUniRule annotation
    Metal bindingi353 – 3531ZincUniRule annotation
    Binding sitei353 – 3531SubstrateUniRule annotation
    Binding sitei407 – 4071SubstrateUniRule annotation
    Metal bindingi412 – 4121ZincUniRule annotation
    Binding sitei412 – 4121SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciBHAL272558:GJC5-3685-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:BH3582
    OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
    Taxonomic identifieri272558 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001258: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424Histidinol dehydrogenasePRO_0000135726Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272558.BH3582.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9K6Z2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9K6Z2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIVTINDSV SLKRDLDTGT DMQQNAVHSI IAQVREQGDQ ALFTLTKQFD    50
    GADLTTLRVQ QAEIEAAYRE MEEPVLQAIG EAIENIRDFH ERQKRNSWMT 100
    TKSDGTILGQ KITPLDSVGL YVPGGKAAYP SSIMMNVIPA QVAGVQNIVI 150
    VSPPQKDGSI PAGVLVTAAE LGVKTILKVG GAQAIAALAY GTESVPAVDK 200
    ITGPGNIYVA LAKRAVFGHV DIDMIAGPSE IVVLADERAN PRYIAADLLS 250
    QAEHDERASA ILVTPSRALA EEVAVEVDQQ LTTLPKREIA AASIRDYGAI 300
    YVTETLEEAV SVVNELAPEH LEILAEEPMS FLGKIRHAGA IFLGPYSSEP 350
    VGDYFAGPNH VLPTNGTARF SSPLNVDDFV KKSSIISYSK AALLENGAKI 400
    SALARLEGLE AHARAIDIRL EDER 424
    Length:424
    Mass (Da):45,496
    Last modified:October 1, 2000 - v1
    Checksum:i705853FD6ECFAF0A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000004 Genomic DNA. Translation: BAB07301.1.
    PIRiF84097.
    RefSeqiNP_244449.1. NC_002570.2.
    WP_010899710.1. NC_002570.2.

    Genome annotation databases

    EnsemblBacteriaiBAB07301; BAB07301; BAB07301.
    GeneIDi893911.
    KEGGibha:BH3582.
    PATRICi18944448. VBIBacHal18977_3722.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000004 Genomic DNA. Translation: BAB07301.1 .
    PIRi F84097.
    RefSeqi NP_244449.1. NC_002570.2.
    WP_010899710.1. NC_002570.2.

    3D structure databases

    ProteinModelPortali Q9K6Z2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272558.BH3582.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB07301 ; BAB07301 ; BAB07301 .
    GeneIDi 893911.
    KEGGi bha:BH3582.
    PATRICi 18944448. VBIBacHal18977_3722.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci BHAL272558:GJC5-3685-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
      Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
      Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

    Entry informationi

    Entry nameiHISX_BACHD
    AccessioniPrimary (citable) accession number: Q9K6Z2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3