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Q9K6Z2

- HISX_BACHD

UniProt

Q9K6Z2 - HISX_BACHD

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Protein
Histidinol dehydrogenase
Gene
hisD, BH3582
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei121 – 1211NAD By similarity
Binding sitei183 – 1831NAD By similarity
Binding sitei206 – 2061NAD By similarity
Binding sitei229 – 2291Substrate By similarity
Metal bindingi251 – 2511Zinc By similarity
Binding sitei251 – 2511Substrate By similarity
Metal bindingi254 – 2541Zinc By similarity
Binding sitei254 – 2541Substrate By similarity
Active sitei319 – 3191Proton acceptor By similarity
Active sitei320 – 3201Proton acceptor By similarity
Binding sitei320 – 3201Substrate By similarity
Metal bindingi353 – 3531Zinc By similarity
Binding sitei353 – 3531Substrate By similarity
Binding sitei407 – 4071Substrate By similarity
Metal bindingi412 – 4121Zinc By similarity
Binding sitei412 – 4121Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-3685-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:BH3582
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001258: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Histidinol dehydrogenaseUniRule annotation
PRO_0000135726Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272558.BH3582.

Structurei

3D structure databases

ProteinModelPortaliQ9K6Z2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9K6Z2-1 [UniParc]FASTAAdd to Basket

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MKIVTINDSV SLKRDLDTGT DMQQNAVHSI IAQVREQGDQ ALFTLTKQFD    50
GADLTTLRVQ QAEIEAAYRE MEEPVLQAIG EAIENIRDFH ERQKRNSWMT 100
TKSDGTILGQ KITPLDSVGL YVPGGKAAYP SSIMMNVIPA QVAGVQNIVI 150
VSPPQKDGSI PAGVLVTAAE LGVKTILKVG GAQAIAALAY GTESVPAVDK 200
ITGPGNIYVA LAKRAVFGHV DIDMIAGPSE IVVLADERAN PRYIAADLLS 250
QAEHDERASA ILVTPSRALA EEVAVEVDQQ LTTLPKREIA AASIRDYGAI 300
YVTETLEEAV SVVNELAPEH LEILAEEPMS FLGKIRHAGA IFLGPYSSEP 350
VGDYFAGPNH VLPTNGTARF SSPLNVDDFV KKSSIISYSK AALLENGAKI 400
SALARLEGLE AHARAIDIRL EDER 424
Length:424
Mass (Da):45,496
Last modified:October 1, 2000 - v1
Checksum:i705853FD6ECFAF0A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000004 Genomic DNA. Translation: BAB07301.1.
PIRiF84097.
RefSeqiNP_244449.1. NC_002570.2.
WP_010899710.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB07301; BAB07301; BAB07301.
GeneIDi893911.
KEGGibha:BH3582.
PATRICi18944448. VBIBacHal18977_3722.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000004 Genomic DNA. Translation: BAB07301.1 .
PIRi F84097.
RefSeqi NP_244449.1. NC_002570.2.
WP_010899710.1. NC_002570.2.

3D structure databases

ProteinModelPortali Q9K6Z2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272558.BH3582.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB07301 ; BAB07301 ; BAB07301 .
GeneIDi 893911.
KEGGi bha:BH3582.
PATRICi 18944448. VBIBacHal18977_3722.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci BHAL272558:GJC5-3685-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
    Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
    Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Entry informationi

Entry nameiHISX_BACHD
AccessioniPrimary (citable) accession number: Q9K6Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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