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Q9K6Z2 (HISX_BACHD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:BH3582
OrganismBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]
Taxonomic identifier272558 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 424424Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135726

Sites

Active site3191Proton acceptor By similarity
Active site3201Proton acceptor By similarity
Metal binding2511Zinc By similarity
Metal binding2541Zinc By similarity
Metal binding3531Zinc By similarity
Metal binding4121Zinc By similarity
Binding site1211NAD By similarity
Binding site1831NAD By similarity
Binding site2061NAD By similarity
Binding site2291Substrate By similarity
Binding site2511Substrate By similarity
Binding site2541Substrate By similarity
Binding site3201Substrate By similarity
Binding site3531Substrate By similarity
Binding site4071Substrate By similarity
Binding site4121Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9K6Z2 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 705853FD6ECFAF0A

FASTA42445,496
        10         20         30         40         50         60 
MKIVTINDSV SLKRDLDTGT DMQQNAVHSI IAQVREQGDQ ALFTLTKQFD GADLTTLRVQ 

        70         80         90        100        110        120 
QAEIEAAYRE MEEPVLQAIG EAIENIRDFH ERQKRNSWMT TKSDGTILGQ KITPLDSVGL 

       130        140        150        160        170        180 
YVPGGKAAYP SSIMMNVIPA QVAGVQNIVI VSPPQKDGSI PAGVLVTAAE LGVKTILKVG 

       190        200        210        220        230        240 
GAQAIAALAY GTESVPAVDK ITGPGNIYVA LAKRAVFGHV DIDMIAGPSE IVVLADERAN 

       250        260        270        280        290        300 
PRYIAADLLS QAEHDERASA ILVTPSRALA EEVAVEVDQQ LTTLPKREIA AASIRDYGAI 

       310        320        330        340        350        360 
YVTETLEEAV SVVNELAPEH LEILAEEPMS FLGKIRHAGA IFLGPYSSEP VGDYFAGPNH 

       370        380        390        400        410        420 
VLPTNGTARF SSPLNVDDFV KKSSIISYSK AALLENGAKI SALARLEGLE AHARAIDIRL 


EDER 

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References

[1]"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000004 Genomic DNA. Translation: BAB07301.1.
PIRF84097.
RefSeqNP_244449.1. NC_002570.2.

3D structure databases

ProteinModelPortalQ9K6Z2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272558.BH3582.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB07301; BAB07301; BAB07301.
GeneID893911.
KEGGbha:BH3582.
PATRIC18944448. VBIBacHal18977_3722.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMAPSEILII.
OrthoDBEOG6CVVCR.
ProtClustDBPRK00877.

Enzyme and pathway databases

BioCycBHAL272558:GJC5-3685-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_BACHD
AccessionPrimary (citable) accession number: Q9K6Z2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2000
Last modified: February 19, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways