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Protein

ATP synthase subunit alpha

Gene

atpA

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.UniRule annotation

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei362Required for activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi169 – 176ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit alphaUniRule annotation (EC:3.6.3.14UniRule annotation)
Alternative name(s):
ATP synthase F1 sector subunit alphaUniRule annotation
F-ATPase subunit alphaUniRule annotation
Gene namesi
Name:atpAUniRule annotation
Ordered Locus Names:BH3756
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, CF(1), Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001443141 – 502ATP synthase subunit alphaAdd BLAST502

Proteomic databases

PRIDEiQ9K6H3

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.UniRule annotation

Protein-protein interaction databases

STRINGi272558.BH3756

Structurei

3D structure databases

ProteinModelPortaliQ9K6H3
SMRiQ9K6H3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDG Bacteria
COG0056 LUCA
HOGENOMiHOG000130111
KOiK02111
OMAiGNAQIKS
OrthoDBiPOG091H01QH

Family and domain databases

CDDicd01132 F1_ATPase_alpha, 1 hit
Gene3Di1.20.150.20, 1 hit
2.40.30.20, 1 hit
HAMAPiMF_01346 ATP_synth_alpha_bact, 1 hit
InterProiView protein in InterPro
IPR023366 ATP_synth_asu-like_sf
IPR000793 ATP_synth_asu_C
IPR038376 ATP_synth_asu_C_sf
IPR033732 ATP_synth_F1_a
IPR005294 ATP_synth_F1_asu
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR036121 ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF00306 ATP-synt_ab_C, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039088 F_ATPase_subunit_alpha, 1 hit
SUPFAMiSSF50615 SSF50615, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00962 atpA, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9K6H3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIKPEEISS LIKQQIENFQ SDVQVQDVGT VIRVGDGIAL AHGLESVMAG
60 70 80 90 100
ELLEFSNGVM GMAQNLEENN VGIIILGPYS EIREGDEVKR TGRIMEVPVG
110 120 130 140 150
EELLGRVVNP LGQPIDGRGP IETSKTRPIE SPAPGVMDRK SVHEPLQTGI
160 170 180 190 200
KSIDSMIPVG RGQRELIIGD RQTGKTSIAI DTIINQKDQD MICIYVAIGQ
210 220 230 240 250
KESTVAGVVE TLRQHGALDY TIVVSASASE PAPLLFLAPY AGVSMGEEFM
260 270 280 290 300
YNGKHVLVVY DDLTKQAAAY RELSLLLRRP PGREAYPGDV FYLHSRLLER
310 320 330 340 350
AAKLSDAKGG GSITALPFIE TQAGDVSAYI PTNVISITDG QIFLQSDLFY
360 370 380 390 400
SGVRPAVNAG LSVSRVGGSA QIKAMKKVSG TLRLDLAAYR ELEAFAQFGS
410 420 430 440 450
DLDKATQAKL NRGQRTVEVL KQGLHEPLPV EKQVAIIYAL INGFLDDIPV
460 470 480 490 500
GDVRRFESEL FTFLDHNKKE LLDHIRTTGN LPDDSEFKAA ITEFKQGFVT

TK
Length:502
Mass (Da):54,645
Last modified:October 1, 2000 - v1
Checksum:iC13EB6EBF2B6D508
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA Translation: BAB07475.1
PIRiD84119
RefSeqiWP_010899881.1, NC_002570.2

Genome annotation databases

EnsemblBacteriaiBAB07475; BAB07475; BAB07475
KEGGibha:BH3756

Entry informationi

Entry nameiATPA_BACHD
AccessioniPrimary (citable) accession number: Q9K6H3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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