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Protein

Agmatinase

Gene

speB

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of putrescine from agmatine.By similarity

Catalytic activityi

Agmatine + H2O = putrescine + urea.

Cofactori

Mn2+PROSITE-ProRule annotation

Pathwayi: putrescine biosynthesis via agmatine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from agmatine.
Proteins known to be involved in this subpathway in this organism are:
  1. Agmatinase (speB)
This subpathway is part of the pathway putrescine biosynthesis via agmatine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from agmatine, the pathway putrescine biosynthesis via agmatine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi112ManganesePROSITE-ProRule annotation1
Metal bindingi135ManganesePROSITE-ProRule annotation1
Metal bindingi137ManganesePROSITE-ProRule annotation1
Metal bindingi139ManganesePROSITE-ProRule annotation1
Metal bindingi216ManganesePROSITE-ProRule annotation1
Metal bindingi218ManganesePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPolyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00534; UER00287

Names & Taxonomyi

Protein namesi
Recommended name:
Agmatinase (EC:3.5.3.11)
Alternative name(s):
Agmatine ureohydrolase
Short name:
AUH
Gene namesi
Name:speB
Ordered Locus Names:BH3810
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001737271 – 289AgmatinaseAdd BLAST289

Interactioni

Protein-protein interaction databases

STRINGi272558.BH3810

Structurei

3D structure databases

ProteinModelPortaliQ9K6B9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family. Agmatinase subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0010 LUCA
KOiK01480
OMAiDTYFGAE
OrthoDBiPOG091H0384

Family and domain databases

InterProiView protein in InterPro
IPR005925 Agmatinase-rel
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
IPR020855 Ureohydrolase_Mn_BS
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01230 agmatinase, 1 hit
PROSITEiView protein in PROSITE
PS01053 ARGINASE_1, 1 hit
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9K6B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFDEAYSGK VFIMSRSNYE KSKAVIFGMP MDWTVSFRPS SRFGPNRIRE
60 70 80 90 100
ASLGLEEYSP YMDKHLEEVA YFDAGDMLLP FGNPQRSLEM IESYVDKLLA
110 120 130 140 150
DQKMPIGLGG EHLVSWPIFK AMHKIYPDMA IIHIDAHADL REEYEGEPLS
160 170 180 190 200
HSTPIRKACS LIGPENVYSF GIRSGMREEF QYAKDSGMYM AKFEVATPLK
210 220 230 240 250
EVLPKLAGRN VYVTIDIDVL DPAFAPGTGT AEAGGISSKE LLEAIVAIAH
260 270 280
SDVNVIGADL VEVAPAYDPS EKTPIAASKF VREMLLGWV
Length:289
Mass (Da):32,155
Last modified:March 15, 2004 - v2
Checksum:i2F8B0C4CA4EB4B89
GO

Sequence cautioni

The sequence BAB07529 differs from that shown. Reason: Frameshift at position 40.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA Translation: BAB07529.1 Frameshift.
PIRiB84126

Genome annotation databases

EnsemblBacteriaiBAB07529; BAB07529; BAB07529
KEGGibha:BH3810

Similar proteinsi

Entry informationi

Entry nameiSPEB_BACHD
AccessioniPrimary (citable) accession number: Q9K6B9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: April 25, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health