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Q9K6B9

- SPEB_BACHD

UniProt

Q9K6B9 - SPEB_BACHD

Protein

Agmatinase

Gene

speB

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (15 Mar 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of putrescine from agmatine.By similarity

    Catalytic activityi

    Agmatine + H2O = putrescine + urea.

    Cofactori

    Manganese.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi112 – 1121ManganesePROSITE-ProRule annotation
    Metal bindingi135 – 1351ManganesePROSITE-ProRule annotation
    Metal bindingi137 – 1371ManganesePROSITE-ProRule annotation
    Metal bindingi139 – 1391ManganesePROSITE-ProRule annotation
    Metal bindingi216 – 2161ManganesePROSITE-ProRule annotation
    Metal bindingi218 – 2181ManganesePROSITE-ProRule annotation

    GO - Molecular functioni

    1. agmatinase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. putrescine biosynthetic process from arginine Source: UniProtKB-UniPathway
    2. spermidine biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciBHAL272558:GJC5-3913-MONOMER.
    UniPathwayiUPA00534; UER00287.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Agmatinase (EC:3.5.3.11)
    Alternative name(s):
    Agmatine ureohydrolase
    Short name:
    AUH
    Gene namesi
    Name:speB
    Ordered Locus Names:BH3810
    OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
    Taxonomic identifieri272558 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001258: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289AgmatinasePRO_0000173727Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272558.BH3810.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9K6B9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the arginase family. Agmatinase subfamily.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0010.
    KOiK01480.
    OMAiSPPYDPF.

    Family and domain databases

    Gene3Di3.40.800.10. 1 hit.
    InterProiIPR005925. Agmatinase-rel.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view]
    PANTHERiPTHR11358. PTHR11358. 1 hit.
    PfamiPF00491. Arginase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036979. Arginase. 1 hit.
    TIGRFAMsiTIGR01230. agmatinase. 1 hit.
    PROSITEiPS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9K6B9-1 [UniParc]FASTAAdd to Basket

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    MRFDEAYSGK VFIMSRSNYE KSKAVIFGMP MDWTVSFRPS SRFGPNRIRE    50
    ASLGLEEYSP YMDKHLEEVA YFDAGDMLLP FGNPQRSLEM IESYVDKLLA 100
    DQKMPIGLGG EHLVSWPIFK AMHKIYPDMA IIHIDAHADL REEYEGEPLS 150
    HSTPIRKACS LIGPENVYSF GIRSGMREEF QYAKDSGMYM AKFEVATPLK 200
    EVLPKLAGRN VYVTIDIDVL DPAFAPGTGT AEAGGISSKE LLEAIVAIAH 250
    SDVNVIGADL VEVAPAYDPS EKTPIAASKF VREMLLGWV 289
    Length:289
    Mass (Da):32,155
    Last modified:March 15, 2004 - v2
    Checksum:i2F8B0C4CA4EB4B89
    GO

    Sequence cautioni

    The sequence BAB07529.1 differs from that shown. Reason: Frameshift at position 40.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000004 Genomic DNA. Translation: BAB07529.1. Frameshift.
    PIRiB84126.
    RefSeqiNP_244677.1. NC_002570.2.

    Genome annotation databases

    EnsemblBacteriaiBAB07529; BAB07529; BAB07529.
    GeneIDi890481.
    KEGGibha:BH3810.
    PATRICi18944936. VBIBacHal18977_3966.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000004 Genomic DNA. Translation: BAB07529.1 . Frameshift.
    PIRi B84126.
    RefSeqi NP_244677.1. NC_002570.2.

    3D structure databases

    ProteinModelPortali Q9K6B9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272558.BH3810.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB07529 ; BAB07529 ; BAB07529 .
    GeneIDi 890481.
    KEGGi bha:BH3810.
    PATRICi 18944936. VBIBacHal18977_3966.

    Phylogenomic databases

    eggNOGi COG0010.
    KOi K01480.
    OMAi SPPYDPF.

    Enzyme and pathway databases

    UniPathwayi UPA00534 ; UER00287 .
    BioCyci BHAL272558:GJC5-3913-MONOMER.

    Family and domain databases

    Gene3Di 3.40.800.10. 1 hit.
    InterProi IPR005925. Agmatinase-rel.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view ]
    PANTHERi PTHR11358. PTHR11358. 1 hit.
    Pfami PF00491. Arginase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036979. Arginase. 1 hit.
    TIGRFAMsi TIGR01230. agmatinase. 1 hit.
    PROSITEi PS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
      Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
      Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

    Entry informationi

    Entry nameiSPEB_BACHD
    AccessioniPrimary (citable) accession number: Q9K6B9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: March 15, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3