Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.By similarity

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylase (EC:3.2.2.27)
Short name:
UDG
Gene namesi
Name:ung
Ordered Locus Names:BH3850
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001760631 – 224Uracil-DNA glycosylaseAdd BLAST224

Interactioni

Protein-protein interaction databases

STRINGi272558.BH3850.

Structurei

3D structure databases

ProteinModelPortaliQ9K682.
SMRiQ9K682.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105D5S. Bacteria.
COG0692. LUCA.
HOGENOMiHOG000229528.
KOiK03648.
OMAiQANGLCF.
OrthoDBiPOG091H03VL.

Family and domain databases

CDDicd10027. UDG_F1. 1 hit.
Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG. 1 hit.
InterProiView protein in InterPro
IPR002043. UDG_fam1.
IPR018085. Ura-DNA_Glyclase_AS.
IPR005122. Uracil-DNA_glycosylase-like.
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiView protein in Pfam
PF03167. UDG. 1 hit.
SMARTiView protein in SMART
SM00986. UDG. 1 hit.
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiView protein in PROSITE
PS00130. U_DNA_GLYCOSYLASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9K682-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILHNDWAD VLEAEFQKPY YVQLREFLKQ EYSTQTIYPS MYDIFNALHY
60 70 80 90 100
TPLAEAKVVI LGQDPYHGPN QAHGLSFSVK PGVPLPPSLQ NIFKELREDL
110 120 130 140 150
GCPIPNNGHL TPWAEQGVLL LNTVLTVRKG QAASHRGKGW ESFTDRVITC
160 170 180 190 200
LNEREKPVIF VLWGRHAQEK QALITNDRHY ILTAPHPSPF SANRGFFGSR
210 220
PFSTINRILQ EQGESQIHWE IPNL
Length:224
Mass (Da):25,582
Last modified:October 1, 2000 - v1
Checksum:iDF8A096F1235E605
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB07569.1.
PIRiB84131.
RefSeqiWP_010899975.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB07569; BAB07569; BAB07569.
KEGGibha:BH3850.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiUNG_BACHD
AccessioniPrimary (citable) accession number: Q9K682
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 1, 2000
Last modified: June 7, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families