Reviewed, UniProtKB/Swiss-Prot Q9K681 (MTLD_BACHD)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	BH3851

Organism

Bacillus halodurans [Complete proteome] [HAMAP]

Taxonomic identifier

86665 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 374	374	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_0000170696
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9K681-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: A9629EBA3AAED434	FASTA	374	41,520
	10 20 30 40 50 60 MKAIHFGAGN IGRGFIGALL SKANYEVVFV DVNAQVIDRL NEQRSYTVLT ADEDNEENVI 70 80 90 100 110 120 HNVRGLNSRT QMEQVLAEIA TADLVTTAVG PSVLPHLAHP IGQGLLQRNG APIQVIACEN 130 140 150 160 170 180 AIGASSMLQE YTKASLSEEE WSKVDRVTGF PNATVDRIVP AQDHADPLTV SVEPFYEWVI 190 200 210 220 230 240 ETKSMKGEPP TIDGVTYVED LTPYIERKLF TVNTGHAMVA YLGFQKGLMT IKEAISDQTI 250 260 270 280 290 300 AEKTRQALAE TKGLLVHKYN FSPEAHDEYI EKIFKRYNNP YLSDRVERVG RNPIRKLGYN 310 320 330 340 350 360 ERLVKPARQL LDLGHQPTAL LAGIQAAFAF FVEDDQESME LQEKRQVQGL EQTVVEVTGL 370 PAVHPLVQMI VGNN

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000004 Genomic DNA. Translation: BAB07570.1.
PIR	C84131.
RefSeq	NP_244718.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	891479.
GenomeReviews	Gene locus BH3851 in contig BA000004_GR.
KEGG	bha:BH3851.
NMPDR	fig|272558.1.peg.3851.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9K681.
OMA	Q9K681. VDRIVPN.
Enzyme and pathway databases
BioCyc	BHAL272558:BH3851-MON.
BRENDA	1.1.1.17. 191865.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_BACHD

Accession

Primary (citable) accession number: Q9K681

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)