Reviewed, UniProtKB/Swiss-Prot Q9K620 (BCES_BACHD)

Names and origin

Protein names

Recommended name:
    Sensor protein bceS
    EC=2.7.13.3

Gene names

Name:	bceS
Ordered Locus Names:	BH3912

Organism

Bacillus halodurans [Complete proteome] [HAMAP]

Taxonomic identifier

86665 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Member of the two-component regulatory system bceS/bceR involved in the regulation of bacitracin resistance. Activates bceR in response to extracellular bacitracin By similarity.
Catalytic activity	ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
Subcellular location	Cell membrane; Multi-pass membrane protein Probable.
Sequence similarities	Contains 1 histidine kinase domain.

Ontologies

Keywords
Biological process	Two-component regulatory system
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	peptidyl-histidine phosphorylation Inferred from electronic annotation. Source: InterPro two-component signal transduction system (phosphorelay) Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW two-component sensor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Sensor protein bceS		PRO_0000074708
Regions
	Transmembrane	13 – 33	21	Potential
	Transmembrane	35 – 55	21	Potential
	Domain	121 – 326	206	Histidine kinase
Amino acid modifications
	Modified residue	124	1	Phosphohistidine; by autocatalysis By similarity
Experimental info
	Sequence conflict	55 – 60	6	VRYKKE → CDIRAQ Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9K620-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 05EC22D4AA471483	FASTA	334	38,498
	10 20 30 40 50 60 MIKTFIKERG SWILIIIFLQ CFTVFIAYLD SAIPLAPVFY SVFLSSMIFL FFLAVRYKKE 70 80 90 100 110 120 TTFYRKLEEW DKDLDVTNLA AAESPFERII EQTIVKQTGY LQEKAHRHET ALEQEKDDLL 130 140 150 160 170 180 AWIHEIKTPL TAMHLIIDRL EDRTIKGQLT YEWMRIHLLL DQQLHQKRIP FMENDLYVEK 190 200 210 220 230 240 VNLESVLHQE IKTLQSWCIQ KGIGFDLQLE VTDVLTDAKW LSFILRQLLS NAVKYSEASD 250 260 270 280 290 300 IIIKSDVVSG KTVVEVTDFG RGIEPKDLPR IFEKGFTSTK TDQTNGATGM GLYLAKRVAE 310 320 330 PLLIDLAVSS TVGEGTTFTL TFPKENEFVR TLGM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.
[2]	"Sequencing of three lambda clones from the genome of alkaliphilic Bacillus sp. strain C-125." Takami H., Nakasone K., Ogasawara N., Hirama C., Nakamura Y., Masui N., Fuji F., Takaki Y., Inoue A., Horikoshi K. Extremophiles 3:29-34(1999) [PubMed: 10086842] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 55-334. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000004 Genomic DNA. Translation: BAB07631.1. AB011838 Genomic DNA. Translation: BAA75355.1. Different initiation.
PIR	H84138.
RefSeq	NP_244780.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	890934.
GenomeReviews	Gene locus BH3912 in contig BA000004_GR.
KEGG	bha:BH3912.
NMPDR	fig|272558.1.peg.3912.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9K620.
OMA	YEWLRIH.
Enzyme and pathway databases
BioCyc	BHAL272558:BH3912-MON.
BRENDA	2.7.13.3. 191865.
Family and domain databases
InterPro	IPR003594. ATP_bd_ATPase. IPR004358. Sig_transdc_His_kin-like_C. IPR003661. Sig_transdc_His_kin_sub1_dim/P. IPR005467. Sig_transdc_His_kinase_core. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
Pfam	PF02518. HATPase_c. 1 hit. [Graphical view]
PRINTS	PR00344. BCTRLSENSOR.
SMART	SM00387. HATPase_c. 1 hit. SM00388. HisKA. 1 hit. [Graphical view]
PROSITE	PS50109. HIS_KIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BCES_BACHD

Accession

Primary (citable) accession number: Q9K620
Secondary accession number(s): Q9Z9S7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
Last sequence update:	October 1, 2000
Last modified:	November 3, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)