ID   Q9K617_HALH5            Unreviewed;       667 AA.
AC   Q9K617;
DT   01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2000, sequence version 1.
DT   27-MAR-2024, entry version 115.
DE   SubName: Full=Methyl-accepting chemotaxis protein {ECO:0000313|EMBL:BAB07634.1};
GN   Name=tlpA {ECO:0000313|EMBL:BAB07634.1};
OS   Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC   Halalkalibacterium (ex Joshi et al. 2022).
OX   NCBI_TaxID=272558 {ECO:0000313|EMBL:BAB07634.1, ECO:0000313|Proteomes:UP000001258};
RN   [1] {ECO:0000313|EMBL:BAB07634.1, ECO:0000313|Proteomes:UP000001258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125
RC   {ECO:0000313|Proteomes:UP000001258};
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000256|ARBA:ARBA00029447}.
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DR   EMBL; BA000004; BAB07634.1; -; Genomic_DNA.
DR   PIR; C84139; C84139.
DR   RefSeq; WP_010900040.1; NC_002570.2.
DR   AlphaFoldDB; Q9K617; -.
DR   STRING; 272558.gene:10729828; -.
DR   KEGG; bha:BH3915; -.
DR   eggNOG; COG0840; Bacteria.
DR   eggNOG; COG4191; Bacteria.
DR   HOGENOM; CLU_000445_107_19_9; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd11386; MCP_signal; 1.
DR   CDD; cd12914; PDC1_DGC_like; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR033479; dCache_1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   InterPro; IPR029151; Sensor-like_sf.
DR   PANTHER; PTHR32089:SF92; LYSOZYME-LIKE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR   Pfam; PF02743; dCache_1; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR   SUPFAM; SSF103190; Sensory domain-like; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001258};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW   ProRule:PRU00284};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        287..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          309..362
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          381..617
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000259|PROSITE:PS50111"
FT   REGION          372..414
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   667 AA;  72731 MW;  FBB8C695A41343DF CRC64;
     MISKLSFFRK SINLKFIVYF LLVGLIPLII MSYMMYQSSS NEIVAKEREA MESQTVSTVD
     GMEQWLEKRL DEIKIVASSE ALQSDRLESK LQLMNVIKNQ DDSYETVVFT GADGIVQAHT
     NEEHIGVLDL SDREYFQNGM AGQDTISSVL ISNATGNRIV VVATPVLSSS GETLGVMSAS
     INFEQLIAQY LHGDQFNQHE VIFIDDQNTI QAHPNDELIG ITVEESGIES DLVSLFATGK
     EESGTSITRV DGEEMLISYA PIEKAGYGIY LLTPLSSVLA VTDHIQMITI MIMAVFTVII
     VLFAIWIARS MSRPIRLITS HVQTIASGDL TSSDLQIKRQ DEIGILAHNV NQMATNLKEV
     IHQVGDSADR VAASSQQLSA SSEEVSRSSE QISESIQQVA SGSEKQSSGV NESTLSLEEV
     SSSVQQIAEA SVQITESANS TIEKAKEGGQ SVENNVETMN KIHESVTDSV QITKMLAERS
     KEINNILDVI TSIAEQTNLL ALNAAIEAAR AGEHGKGFAV VADEVRKLAE SSQHSSQQIS
     EIVVEIQKEM DRTSTAMNGV MEEVKDGLTV ANETKTHFQE IIQSTNQVAE QIESMAATSE
     EISAEVEQVS ASFNEIAVIA ENTSDSAQDV AAASEEQLAT MEEVTSSAQY LSQMATDLRE
     LLSKFKV
//