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Protein

Serine-protein kinase RsbW

Gene

rsbW

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: UniProtKB-KW
  • sigma factor antagonist activity Source: TIGR

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciANTHRA:RSBW-MONOMER.
BANT260799:GJAJ-1005-MONOMER.
BANT261594:GJ7F-1050-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-protein kinase RsbWUniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Anti-sigma-B factorUniRule annotation
Sigma-B negative effector RsbWUniRule annotation
Gene namesi
Name:rsbWUniRule annotation
Ordered Locus Names:BA_0991, GBAA_0991, BAS0927
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160Serine-protein kinase RsbWPRO_0000203525Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ9K5J7. 1 interaction.
STRINGi198094.BA_0991.

Structurei

3D structure databases

ProteinModelPortaliQ9K5J7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2172. LUCA.
HOGENOMiHOG000269932.
KOiK04757.
OMAiKMGFSYE.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00638. Anti_sigma_B. 1 hit.
InterProiIPR003594. HATPase_C.
IPR010193. RsbW.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01924. rsbW_low_gc. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9K5J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMERFEKIEM KIPAKAEYVA IIRLTMAGVA NRMGFAYDDI EDMKIAISEA
60 70 80 90 100
CTNIVQHAYK EDVGEIAIVF GLYENRLEIM VADNGVSFDF NNLRSKVGPY
110 120 130 140 150
DISKPVEHLP ENGLGLYLIN TLMDDIQIMH DEGMTVLMTK YIQREQVEND
160
GNPISTYESY
Length:160
Mass (Da):18,241
Last modified:June 16, 2003 - v2
Checksum:i20DC9C9185E887AA
GO

Sequence cautioni

The sequence CAB95033 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272497 Genomic DNA. Translation: CAB95033.1. Different initiation.
AE016879 Genomic DNA. Translation: AAP24978.1.
AE017334 Genomic DNA. Translation: AAT30094.1.
AE017225 Genomic DNA. Translation: AAT53252.1.
RefSeqiNP_843492.1. NC_003997.3.
WP_000970578.1. NZ_LHUO01000014.1.
YP_027201.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP24978; AAP24978; BA_0991.
AAT30094; AAT30094; GBAA_0991.
AAT53252; AAT53252; BAS0927.
GeneIDi1088183.
2850203.
KEGGiban:BA_0991.
bar:GBAA_0991.
bat:BAS0927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272497 Genomic DNA. Translation: CAB95033.1. Different initiation.
AE016879 Genomic DNA. Translation: AAP24978.1.
AE017334 Genomic DNA. Translation: AAT30094.1.
AE017225 Genomic DNA. Translation: AAT53252.1.
RefSeqiNP_843492.1. NC_003997.3.
WP_000970578.1. NZ_LHUO01000014.1.
YP_027201.1. NC_005945.1.

3D structure databases

ProteinModelPortaliQ9K5J7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9K5J7. 1 interaction.
STRINGi198094.BA_0991.

Protocols and materials databases

DNASUi1088183.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP24978; AAP24978; BA_0991.
AAT30094; AAT30094; GBAA_0991.
AAT53252; AAT53252; BAS0927.
GeneIDi1088183.
2850203.
KEGGiban:BA_0991.
bar:GBAA_0991.
bat:BAS0927.

Phylogenomic databases

eggNOGiCOG2172. LUCA.
HOGENOMiHOG000269932.
KOiK04757.
OMAiKMGFSYE.

Enzyme and pathway databases

BioCyciANTHRA:RSBW-MONOMER.
BANT260799:GJAJ-1005-MONOMER.
BANT261594:GJ7F-1050-MONOMER.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00638. Anti_sigma_B. 1 hit.
InterProiIPR003594. HATPase_C.
IPR010193. RsbW.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01924. rsbW_low_gc. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRSBW_BACAN
AccessioniPrimary (citable) accession number: Q9K5J7
Secondary accession number(s): Q6I2H9, Q6KWA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: June 16, 2003
Last modified: September 7, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.