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Protein

Serine-protein kinase RsbW

Gene

rsbW

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: UniProtKB-KW
  • sigma factor antagonist activity Source: TIGR

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-protein kinase RsbWUniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Anti-sigma-B factorUniRule annotation
Sigma-B negative effector RsbWUniRule annotation
Gene namesi
Name:rsbWUniRule annotation
Ordered Locus Names:BA_0991, GBAA_0991, BAS0927
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002035251 – 160Serine-protein kinase RsbWAdd BLAST160

Interactioni

Protein-protein interaction databases

IntActiQ9K5J7, 1 interactor
STRINGi260799.BAS0927

Structurei

3D structure databases

ProteinModelPortaliQ9K5J7
SMRiQ9K5J7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2172 LUCA
HOGENOMiHOG000269932
KOiK04757
OMAiKMGFSYE

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
HAMAPiMF_00638 Anti_sigma_B, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR010193 RsbW
PfamiView protein in Pfam
PF13581 HATPase_c_2, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR01924 rsbW_low_gc, 1 hit

Sequencei

Sequence statusi: Complete.

Q9K5J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMERFEKIEM KIPAKAEYVA IIRLTMAGVA NRMGFAYDDI EDMKIAISEA
60 70 80 90 100
CTNIVQHAYK EDVGEIAIVF GLYENRLEIM VADNGVSFDF NNLRSKVGPY
110 120 130 140 150
DISKPVEHLP ENGLGLYLIN TLMDDIQIMH DEGMTVLMTK YIQREQVEND
160
GNPISTYESY
Length:160
Mass (Da):18,241
Last modified:June 16, 2003 - v2
Checksum:i20DC9C9185E887AA
GO

Sequence cautioni

The sequence CAB95033 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272497 Genomic DNA Translation: CAB95033.1 Different initiation.
AE016879 Genomic DNA Translation: AAP24978.1
AE017334 Genomic DNA Translation: AAT30094.1
AE017225 Genomic DNA Translation: AAT53252.1
RefSeqiNP_843492.1, NC_003997.3
WP_000970578.1, NZ_PPES01000003.1
YP_027201.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP24978; AAP24978; BA_0991
AAT30094; AAT30094; GBAA_0991
AAT53252; AAT53252; BAS0927
GeneIDi1088183
2850203
KEGGiban:BA_0991
bar:GBAA_0991
bat:BAS0927
PATRICifig|198094.11.peg.982

Similar proteinsi

Entry informationi

Entry nameiRSBW_BACAN
AccessioniPrimary (citable) accession number: Q9K5J7
Secondary accession number(s): Q6I2H9, Q6KWA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: June 16, 2003
Last modified: May 23, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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