Reviewed, UniProtKB/Swiss-Prot Q9K575 (OTCC_LACLM)

Names and origin

Protein names

Recommended name:
    Ornithine carbamoyltransferase, catabolic
      Short name=OTCase
    EC=2.1.3.3

Gene names

Name:	arcB
Ordered Locus Names:	llmg_2312

Organism

Lactococcus lactis subsp. cremoris (strain MG1363) [Complete proteome] [HAMAP]

Taxonomic identifier

416870 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Ornithine carbamoyltransferase, catabolic HAMAP MF_01109		PRO_0000112936
Regions
	Region	67 – 71	5	Carbamoyl phosphate binding By similarity
	Region	283 – 286	4	Ornithine binding By similarity
Sites
	Binding site	118	1	Carbamoyl phosphate By similarity
	Binding site	145	1	Carbamoyl phosphate By similarity
	Site	42	1	Important for structural integrity By similarity
	Site	158	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9K575-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 30A7590D431FCBEE	FASTA	354	39,468
	10 20 30 40 50 60 MTSPLITKAE VNSVFQGRSL LAEKDFTPAE INYLVDFGLH LKALKQQNIP HHYLEGKNIA 70 80 90 100 110 120 LLFAKTSTRT RAAFTTAAID LGAHPEYLGA NDIQLGIKES TEDTARVLGS MFDAIERRGF 130 140 150 160 170 180 SQKEVEDLAK YSGVPVWNGL TDDWHPTQMI ADFMTVKENF GYLKGLTLVY VGDGRNNMAN 190 200 210 220 230 240 SLIVTGSMLG VNVHIVAPDS LHPSKEVMDI ANKFAEKSGA KPLATSNIEE GVKGANIIYS 250 260 270 280 290 300 DVWVSMGESN WEERVKLLTP YRITMDMLKM TGNADNGKLI FMHCLPAFHD TETEYGKEIK 310 320 330 340 350 EKYGLTEMEV TDEVFRSKYA RQFEEAENRM HSIKAIMAAT LGNLFIPAVP EDFK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, sequencing and analysis of the genes involved in the arginine deiminase pathway of Lactococus lactis." Aungpraphapornchai P., Mulholland F., Griffin H.G., Gasson M.J. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363." Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C., Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P., van Sinderen D., Kok J. J. Bacteriol. 189:3256-3270(2007) [PubMed: 17307855] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ250129 Genomic DNA. Translation: CAB93580.1. AM406671 Genomic DNA. Translation: CAL98876.1.
RefSeq	YP_001033557.1.
3D structure databases
SMR	Q9K575. Positions 14-344.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9K575.
Genome annotation databases
GeneID	4796868.
GenomeReviews	Gene locus llmg_2312 in contig AM406671_GR.
KEGG	llm:llmg_2312.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0078.
HOGENOM	HBG579429.
OMA	NHETVES.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002292. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
TIGRFAMs	TIGR00658. orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC_LACLM

Accession

Primary (citable) accession number: Q9K575
Secondary accession number(s): A2RNI6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	October 1, 2000
Last modified:	February 9, 2010
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)