Q9K4Z7 (ARGE_MORPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylornithine deacetylase
Short name=AO
Short name=Acetylornithinase
EC=3.5.1.16

Alternative name(s):
N-acetylornithinase
Short name=NAO

Gene names

Name:

argE

Organism

Moritella profunda

Taxonomic identifier

111291 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Moritellaceae › Moritella

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	N(2)-acetyl-L-ornithine + H2O = acetate + L-ornithine. HAMAP MF_01108
Cofactor	Binds 2 zinc or cobalt ions per subunit By similarity. HAMAP MF_01108 Glutathione By similarity. HAMAP MF_01108
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1. HAMAP MF_01108
Subunit structure	Homodimer By similarity. HAMAP MF_01108
Subcellular location	Cytoplasm Probable HAMAP MF_01108.
Sequence similarities	Belongs to the peptidase M20A family. ArgE subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	Cobalt Metal-binding Zinc
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetylornithine deacetylase activity Inferred from electronic annotation. Source: EC cobalt ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	Acetylornithine deacetylase HAMAP MF_01108		PRO_0000185244
Sites
	Active site	80	1	By similarity
	Active site	142	1	Proton acceptor By similarity
	Metal binding	78	1	Cobalt or zinc 1 By similarity
	Metal binding	110	1	Cobalt or zinc 1 By similarity
	Metal binding	110	1	Cobalt or zinc 2 By similarity
	Metal binding	143	1	Cobalt or zinc 2 By similarity
	Metal binding	167	1	Cobalt or zinc 1 By similarity
	Metal binding	353	1	Cobalt or zinc 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9K4Z7 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: D90ECED91273C058	FASTA	381	41,868
	10 20 30 40 50 60 MQLPKFNELY KSLILTPSIS SLEKELDISN KPVIDLLAAW FSELGFSINI TSVPETNGKF 70 80 90 100 110 120 NLVATYGQGD GGLLLAGHTD TVPFDDGLWT KDPFQLTEKD DKWYGLGTID MKGFFAFVLE 130 140 150 160 170 180 ACKNIDLTKL DKPLRILATA DEETTMAGAR AIAAAKSFRP DYAVIGEPTS MVPVFMHKGH 190 200 210 220 230 240 MSEAIRITGR SGHSSDPANG INAIEIMHQV TGQLLQLQRK LKEQYACDHF VIPQPTLNFG 250 260 270 280 290 300 HVHGGDSPNR ICGSCELHID MRPIPGVNPD ELFMLLNQAL LPIMKQWPGA VDVYHLHEPI 310 320 330 340 350 360 PAYACDTDSA LIKLAEKLTG ETVIPVNYCT EAPFIHTGCD TIVMGPGSIN QAHQPDEYLD 370 380 LSAIKPTQAI IQKLIEQSCK N

References

[1]

"Evolution of arginine biosynthesis in the bacterial domain: novel gene-enzyme relationships from psychrophilic Moritella strains (Vibrionaceae) and evolutionary significance of N-alpha-acetyl ornithinase." Xu Y., Liang Z., Legrain C., Ruger H.J., Glansdorff N. J. Bacteriol. 182:1609-1615(2000) [PubMed: 10692366] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION. Strain: 2674.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ252020 Genomic DNA. Translation: CAB95013.1.
3D structure databases
ProteinModelPortal	Q9K4Z7.
ModBase	Search...
Protein family/group databases
MEROPS	M20.974.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_01108. ArgE. [Tree]
InterPro	IPR010169. AcOrn-deacetyl. IPR001261. ArgE/DapE_CS. IPR002933. Peptidase_M20. IPR011650. Peptidase_M20_dimer. [Graphical view]
Pfam	PF07687. M20_dimer. 1 hit. PF01546. Peptidase_M20. 1 hit. [Graphical view]
SUPFAM	SSF55031. Peptidase_M20_dimer. 1 hit.
TIGRFAMs	TIGR01892. AcOrn-deacetyl. 1 hit.
PROSITE	PS00758. ARGE_DAPE_CPG2_1. 1 hit. PS00759. ARGE_DAPE_CPG2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGE_MORPR

Accession

Primary (citable) accession number: Q9K4Z7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	October 1, 2000
Last modified:	September 21, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program