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Q9K4Z3

- ASSY_MORPR

UniProt

Q9K4Z3 - ASSY_MORPR

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Protein

Argininosuccinate synthase

Gene
argG
Organism
Moritella profunda
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei93 – 931Citrulline By similarity
Binding sitei98 – 981Citrulline By similarity
Binding sitei123 – 1231ATP; via amide nitrogen By similarity
Binding sitei125 – 1251Aspartate By similarity
Binding sitei129 – 1291Aspartate By similarity
Binding sitei129 – 1291Citrulline By similarity
Binding sitei130 – 1301Aspartate By similarity
Binding sitei133 – 1331Citrulline By similarity
Binding sitei182 – 1821Citrulline By similarity
Binding sitei191 – 1911Citrulline By similarity
Binding sitei267 – 2671Citrulline By similarity
Binding sitei279 – 2791Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 219ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
OrganismiMoritella profunda
Taxonomic identifieri111291 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesMoritellaceaeMoritella

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Argininosuccinate synthaseUniRule annotationPRO_0000148613Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9K4Z3.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9K4Z3-1 [UniParc]FASTAAdd to Basket

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MKMTQTVKKV VVAYSGGLDT SVILPWLQEN YDNCEIVAFV ADVGQGAEEL    50
EGIEAKALAS GASECYVVDL KDELVENYIY PTLKTGAVYE GTYLLGTSMA 100
RPIIAKAQVE IARKVGADAL CHGCTGKGND QIRFESCFAA LAPELTVIAP 150
WRIWDLTSRE SLLEYLAERD IPTAASATKI YSRDANAWHI SHEGGELEDP 200
WNQPSKQVWT MTVDPIDAPN EPEFLTISVV KGEITAVNGE AMSPYNTLMY 250
LNEKAAAHGV GRVDIVENRL VGMKSRGCYE TPGGTVMVEA LRGIEELVLD 300
KTTRKWKQTV AAEFSHLVYD GRWFTPLCAS LLAAAGTLAE EMNGEVIVKM 350
YKGSVQAIQK KSPNSLYSEE FATFGDDNVY DQSHAEGFIR LYSLSSRIKA 400
LASK 404
Length:404
Mass (Da):44,291
Last modified:October 1, 2000 - v1
Checksum:iEBE8AFBAB4E87F20
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ252020 Genomic DNA. Translation: CAB95017.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ252020 Genomic DNA. Translation: CAB95017.1 .

3D structure databases

ProteinModelPortali Q9K4Z3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of arginine biosynthesis in the bacterial domain: novel gene-enzyme relationships from psychrophilic Moritella strains (Vibrionaceae) and evolutionary significance of N-alpha-acetyl ornithinase."
    Xu Y., Liang Z., Legrain C., Ruger H.J., Glansdorff N.
    J. Bacteriol. 182:1609-1615(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 2674.

Entry informationi

Entry nameiASSY_MORPR
AccessioniPrimary (citable) accession number: Q9K4Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2000
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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