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Protein

Superoxide dismutase [Mn/Fe]

Gene

sodA

Organism
Staphylococcus xylosus
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Also contributes to the inhibition of lipid oxidation. Manganese-preferring enzyme, less active with iron than with manganese.2 Publications

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.1 Publication

Cofactori

Mn2+1 Publication, Fe2+1 PublicationNote: Binds 1 Mn2+ or Fe2+ ion per subunit.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Manganese or ironBy similarity
Metal bindingi81 – 811Manganese or ironBy similarity
Metal bindingi161 – 1611Manganese or ironBy similarity
Metal bindingi165 – 1651Manganese or ironBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Stress response

Keywords - Ligandi

Iron, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn/Fe] (EC:1.15.1.1)
Gene namesi
Name:sodA
Synonyms:sod
OrganismiStaphylococcus xylosus
Taxonomic identifieri1288 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Superoxide dismutase [Mn/Fe]PRO_0000226590Add
BLAST

Proteomic databases

PRIDEiQ9K4V3.

Expressioni

Inductioni

Transcription increases slightly by internally generated superoxide stress.1 Publication

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9K4V3.
SMRiQ9K4V3. Positions 2-196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9K4V3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFELPNLPY GFDALEPHID QQTMEIHHGK HHNTYVTKLN AAVEGTDLES
60 70 80 90 100
KSIEEIVANL DSVPENIQTA VRNNGGGHLN HSLFWELLTP NSEEKGTVVD
110 120 130 140 150
KIKEQWGSLD AFKEEFADKA AARFGSGWAW LVVNNGNLEI VTTPNQDNPI
160 170 180 190
TEGKTPILGL DVWEHAYYLK YQNKRPDYIS AFWNVVNWEK VDELYNAAK
Length:199
Mass (Da):22,535
Last modified:October 1, 2000 - v1
Checksum:iA44EBE636368A2A2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101Y → F in AAS78509 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 122GF → AY in strain: CS6.
Natural varianti12 – 121F → C in strain: 5SI5K.
Natural varianti23 – 231T → P in strain: NEM2021.
Natural varianti25 – 251E → V in strain: 5SI5K.
Natural varianti43 – 431V → I in strain: S087.
Natural varianti61 – 611D → G in strain: S087.
Natural varianti96 – 961G → D in strain: NEM2021.
Natural varianti105 – 1051Q → H in strain: NEM2022.
Natural varianti111 – 1111A → T in strain: 1K07.
Natural varianti147 – 1471D → V in strain: A4065G.
Natural varianti150 – 1512IT → MN in strain: A4065G.
Natural varianti150 – 1501I → M in strain: C4068G.
Natural varianti181 – 1811A → S in strain: 42M06.
Natural varianti189 – 1891E → G in strain: 41M06.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276960 Genomic DNA. Translation: CAB95744.1.
AY571678 Genomic DNA. Translation: AAS78509.1.
AY571679 Genomic DNA. Translation: AAS78510.1.
AY571680 Genomic DNA. Translation: AAS78511.1.
AY571681 Genomic DNA. Translation: AAS78512.1.
AY571682 Genomic DNA. Translation: AAS78513.1.
AY571683 Genomic DNA. Translation: AAS78514.1.
AY571684 Genomic DNA. Translation: AAS78515.1.
AY571685 Genomic DNA. Translation: AAS78516.1.
AY571686 Genomic DNA. Translation: AAS78517.1.
AY571687 Genomic DNA. Translation: AAS78518.1.
AY571688 Genomic DNA. Translation: AAS78520.1.
AY571689 Genomic DNA. Translation: AAS78522.1.
AY571690 Genomic DNA. Translation: AAS78524.1.
AY571691 Genomic DNA. Translation: AAS78526.1.
AY571692 Genomic DNA. Translation: AAS78527.1.
AY571693 Genomic DNA. Translation: AAS78529.1.
AY571694 Genomic DNA. Translation: AAS78531.1.
AY571697 Genomic DNA. Translation: AAS78534.1.
AY571699 Genomic DNA. Translation: AAS78536.1.
AY571700 Genomic DNA. Translation: AAS78537.1.
AY571702 Genomic DNA. Translation: AAS78539.1.
AY571703 Genomic DNA. Translation: AAS78540.1.
AY571704 Genomic DNA. Translation: AAS78541.1.
AY571705 Genomic DNA. Translation: AAS78542.1.
AY571706 Genomic DNA. Translation: AAS78543.1.
AY571707 Genomic DNA. Translation: AAS78544.1.
AY485205 Genomic DNA. Translation: AAR83767.1.
AY485206 Genomic DNA. Translation: AAR83768.1.
AY485207 Genomic DNA. Translation: AAR83769.1.
AJ343933 Genomic DNA. Translation: CAC86515.1.
AJ343959 Genomic DNA. Translation: CAC86541.1.
AJ343960 Genomic DNA. Translation: CAC86542.1.
RefSeqiWP_017724588.1. NZ_LN554884.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276960 Genomic DNA. Translation: CAB95744.1.
AY571678 Genomic DNA. Translation: AAS78509.1.
AY571679 Genomic DNA. Translation: AAS78510.1.
AY571680 Genomic DNA. Translation: AAS78511.1.
AY571681 Genomic DNA. Translation: AAS78512.1.
AY571682 Genomic DNA. Translation: AAS78513.1.
AY571683 Genomic DNA. Translation: AAS78514.1.
AY571684 Genomic DNA. Translation: AAS78515.1.
AY571685 Genomic DNA. Translation: AAS78516.1.
AY571686 Genomic DNA. Translation: AAS78517.1.
AY571687 Genomic DNA. Translation: AAS78518.1.
AY571688 Genomic DNA. Translation: AAS78520.1.
AY571689 Genomic DNA. Translation: AAS78522.1.
AY571690 Genomic DNA. Translation: AAS78524.1.
AY571691 Genomic DNA. Translation: AAS78526.1.
AY571692 Genomic DNA. Translation: AAS78527.1.
AY571693 Genomic DNA. Translation: AAS78529.1.
AY571694 Genomic DNA. Translation: AAS78531.1.
AY571697 Genomic DNA. Translation: AAS78534.1.
AY571699 Genomic DNA. Translation: AAS78536.1.
AY571700 Genomic DNA. Translation: AAS78537.1.
AY571702 Genomic DNA. Translation: AAS78539.1.
AY571703 Genomic DNA. Translation: AAS78540.1.
AY571704 Genomic DNA. Translation: AAS78541.1.
AY571705 Genomic DNA. Translation: AAS78542.1.
AY571706 Genomic DNA. Translation: AAS78543.1.
AY571707 Genomic DNA. Translation: AAS78544.1.
AY485205 Genomic DNA. Translation: AAR83767.1.
AY485206 Genomic DNA. Translation: AAR83768.1.
AY485207 Genomic DNA. Translation: AAR83769.1.
AJ343933 Genomic DNA. Translation: CAC86515.1.
AJ343959 Genomic DNA. Translation: CAC86541.1.
AJ343960 Genomic DNA. Translation: CAC86542.1.
RefSeqiWP_017724588.1. NZ_LN554884.1.

3D structure databases

ProteinModelPortaliQ9K4V3.
SMRiQ9K4V3. Positions 2-196.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9K4V3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of the single superoxide dismutase of Staphylococcus xylosus."
    Barriere C., Brueckner R., Talon R.
    Appl. Environ. Microbiol. 67:4096-4104(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, ENZYMATIC ACTIVITY, EXPRESSION, INDUCTION, COFACTOR.
    Strain: DSM 20267 / Isolate C2A.
  2. "Sequence polymorphism of Staphylococcus xylosus katA and sodA genes: detection of some atypical Staphylococcus xylosus strains."
    Blaiotta G., Fusco V., Ercolini D., Coppola S.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 1K07, 25K26, 41M06, 42M06, 5SI3K, 5SI4K, 5SI5K, A4065G, AS141, ATCC 29971 / CIP 81.66 / DSM 20266 / JCM 2418 / LMG 20217, C4063G, C4068G, CS7, DS20, L11, S022, S087, S734, S878, S892, S904, S935, Sx011, Sx1256 and Sx910.
  3. "Superoxide dismutase and catalase activities in coagulase-negative staphylococci (CNS) isolated from fermented dry sausages."
    Blaiotta G., Zinno P., Gianluigi M.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-159.
    Strain: 41M06, CS6 and DS20.
  4. "Rapid and accurate species-level identification of coagulase-negative staphylococci by using the sodA gene as a target."
    Poyart C., Quesne G., Boumaila C., Trieu-Cuot P.
    J. Clin. Microbiol. 39:4296-4301(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-160.
    Strain: ATCC 29971 / CIP 81.66 / DSM 20266 / JCM 2418 / LMG 20217, NEM2021 and NEM2022.
  5. "Roles of superoxide dismutase and catalase of Staphylococcus xylosus in the inhibition of linoleic acid oxidation."
    Barriere C., Centeno D., Lebert A., Leroy-Setrin S., Berdague J.L., Talon R.
    FEMS Microbiol. Lett. 201:181-185(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: DSM 20267 / Isolate C2A.

Entry informationi

Entry nameiSODM_STAXY
AccessioniPrimary (citable) accession number: Q9K4V3
Secondary accession number(s): Q6PXZ5
, Q6PXZ6, Q6PXZ7, Q6PXZ8, Q6PY00, Q6PY03, Q6PY06, Q6PY21, Q6PY22, Q6PY24, Q6PY25, Q6PY27, Q6PY28, Q6RYX8, Q6RYX9, Q8VKW0, Q8VLZ4, Q8VLZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2000
Last modified: March 16, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The levels of SOD activity and sodA expression were growth-phase dependent, occurring most during stationary phase. Expression is not affected by manganese. Is not essential for aerobic growth in complex medium.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.