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Protein

Superoxide dismutase [Mn/Fe]

Gene

sodA

Organism
Staphylococcus xylosus
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Also contributes to the inhibition of lipid oxidation. Manganese-preferring enzyme, less active with iron than with manganese.2 Publications

Miscellaneous

The levels of SOD activity and sodA expression were growth-phase dependent, occurring most during stationary phase. Expression is not affected by manganese. Is not essential for aerobic growth in complex medium.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.1 Publication

Cofactori

Mn2+1 Publication, Fe2+1 PublicationNote: Binds 1 Mn2+ or Fe2+ ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27Manganese or ironBy similarity1
Metal bindingi81Manganese or ironBy similarity1
Metal bindingi161Manganese or ironBy similarity1
Metal bindingi165Manganese or ironBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processStress response
LigandIron, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn/Fe] (EC:1.15.1.1)
Gene namesi
Name:sodA
Synonyms:sod
OrganismiStaphylococcus xylosus
Taxonomic identifieri1288 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002265901 – 199Superoxide dismutase [Mn/Fe]Add BLAST199

Expressioni

Inductioni

Transcription increases slightly by internally generated superoxide stress.1 Publication

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9K4V3
SMRiQ9K4V3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9K4V3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFELPNLPY GFDALEPHID QQTMEIHHGK HHNTYVTKLN AAVEGTDLES
60 70 80 90 100
KSIEEIVANL DSVPENIQTA VRNNGGGHLN HSLFWELLTP NSEEKGTVVD
110 120 130 140 150
KIKEQWGSLD AFKEEFADKA AARFGSGWAW LVVNNGNLEI VTTPNQDNPI
160 170 180 190
TEGKTPILGL DVWEHAYYLK YQNKRPDYIS AFWNVVNWEK VDELYNAAK
Length:199
Mass (Da):22,535
Last modified:October 1, 2000 - v1
Checksum:iA44EBE636368A2A2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10Y → F in AAS78509 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti11 – 12GF → AY in strain: CS6. 2
Natural varianti12F → C in strain: 5SI5K. 1
Natural varianti23T → P in strain: NEM2021. 1
Natural varianti25E → V in strain: 5SI5K. 1
Natural varianti43V → I in strain: S087. 1
Natural varianti61D → G in strain: S087. 1
Natural varianti96G → D in strain: NEM2021. 1
Natural varianti105Q → H in strain: NEM2022. 1
Natural varianti111A → T in strain: 1K07. 1
Natural varianti147D → V in strain: A4065G. 1
Natural varianti150 – 151IT → MN in strain: A4065G. 2
Natural varianti150I → M in strain: C4068G. 1
Natural varianti181A → S in strain: 42M06. 1
Natural varianti189E → G in strain: 41M06. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276960 Genomic DNA Translation: CAB95744.1
AY571678 Genomic DNA Translation: AAS78509.1
AY571679 Genomic DNA Translation: AAS78510.1
AY571680 Genomic DNA Translation: AAS78511.1
AY571681 Genomic DNA Translation: AAS78512.1
AY571682 Genomic DNA Translation: AAS78513.1
AY571683 Genomic DNA Translation: AAS78514.1
AY571684 Genomic DNA Translation: AAS78515.1
AY571685 Genomic DNA Translation: AAS78516.1
AY571686 Genomic DNA Translation: AAS78517.1
AY571687 Genomic DNA Translation: AAS78518.1
AY571688 Genomic DNA Translation: AAS78520.1
AY571689 Genomic DNA Translation: AAS78522.1
AY571690 Genomic DNA Translation: AAS78524.1
AY571691 Genomic DNA Translation: AAS78526.1
AY571692 Genomic DNA Translation: AAS78527.1
AY571693 Genomic DNA Translation: AAS78529.1
AY571694 Genomic DNA Translation: AAS78531.1
AY571697 Genomic DNA Translation: AAS78534.1
AY571699 Genomic DNA Translation: AAS78536.1
AY571700 Genomic DNA Translation: AAS78537.1
AY571702 Genomic DNA Translation: AAS78539.1
AY571703 Genomic DNA Translation: AAS78540.1
AY571704 Genomic DNA Translation: AAS78541.1
AY571705 Genomic DNA Translation: AAS78542.1
AY571706 Genomic DNA Translation: AAS78543.1
AY571707 Genomic DNA Translation: AAS78544.1
AY485205 Genomic DNA Translation: AAR83767.1
AY485206 Genomic DNA Translation: AAR83768.1
AY485207 Genomic DNA Translation: AAR83769.1
AJ343933 Genomic DNA Translation: CAC86515.1
AJ343959 Genomic DNA Translation: CAC86541.1
AJ343960 Genomic DNA Translation: CAC86542.1
RefSeqiWP_017724588.1, NZ_PPQM01000113.1

Genome annotation databases

GeneIDi29396495

Similar proteinsi

Entry informationi

Entry nameiSODM_STAXY
AccessioniPrimary (citable) accession number: Q9K4V3
Secondary accession number(s): Q6PXZ5
, Q6PXZ6, Q6PXZ7, Q6PXZ8, Q6PY00, Q6PY03, Q6PY06, Q6PY21, Q6PY22, Q6PY24, Q6PY25, Q6PY27, Q6PY28, Q6RYX8, Q6RYX9, Q8VKW0, Q8VLZ4, Q8VLZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health