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Protein

Release factor glutamine methyltransferase

Gene

prmC

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + [peptide chain release factor 1 or 2]-L-glutamine = S-adenosyl-L-homocysteine + [peptide chain release factor 1 or 2]-N5-methyl-L-glutamine.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei142S-adenosyl-L-methionineUniRule annotation1
Binding sitei184S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Release factor glutamine methyltransferaseUniRule annotation (EC:2.1.1.297UniRule annotation)
Short name:
RF MTaseUniRule annotation
Alternative name(s):
N5-glutamine methyltransferase PrmCUniRule annotation
Protein-(glutamine-N5) MTase PrmCUniRule annotation
Protein-glutamine N-methyltransferase PrmCUniRule annotation
Gene namesi
Name:prmCUniRule annotation
Ordered Locus Names:SCO5361
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004145451 – 281Release factor glutamine methyltransferaseAdd BLAST281

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO5361

Structurei

3D structure databases

ProteinModelPortaliQ9K4E3
SMRiQ9K4E3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni184 – 187Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EQY Bacteria
COG2890 LUCA
HOGENOMiHOG000076276
InParanoidiQ9K4E3
KOiK02493
OMAiMLVSNPP
OrthoDBiPOG091H02CJ
PhylomeDBiQ9K4E3

Family and domain databases

HAMAPiMF_02126 RF_methyltr_PrmC, 1 hit
InterProiView protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR004556 Modification_methylase_HemK
IPR019874 Release_fac_Glu-N5_MeTfrase
IPR029063 SAM-dependent_MTases
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00536 hemK_fam, 1 hit
TIGR03534 RF_mod_PrmC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9K4E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLLLAEVAQ ATQRLADAGV PSPRTDAEEL AAYLHGVKRG ELHTVPDADF
60 70 80 90 100
DARYWEVVAR REAREPLQHI TGRAYFRYLE LQVGPGVFVP RPETESVVGW
110 120 130 140 150
AIDAVRAMDV VEPCIVDLCT GSGAIALALA QEVPRSRVHA VELSEDALKW
160 170 180 190 200
TRRNMEGSRV DLRQGDALTA FPDLDGQVDL VVSNPPYIPL TEWEYVAPEA
210 220 230 240 250
RDHDPELALF SGEDGLDLIR GLERTAHRLL RPGGVVVVEH ADTQGGQVPW
260 270 280
IFTEERGWAD AADHPDLNNR PRFATARKAL P
Length:281
Mass (Da):31,073
Last modified:October 1, 2000 - v1
Checksum:i588A4217630BED5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939123 Genomic DNA Translation: CAB94532.1
RefSeqiNP_629500.1, NC_003888.3
WP_003973636.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB94532; CAB94532; CAB94532
GeneIDi1100801
KEGGisco:SCO5361
PATRICifig|100226.15.peg.5441

Entry informationi

Entry nameiPRMC_STRCO
AccessioniPrimary (citable) accession number: Q9K4E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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