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Protein

Release factor glutamine methyltransferase

Gene

prmC

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + [peptide chain release factor 1 or 2]-L-glutamine = S-adenosyl-L-homocysteine + [peptide chain release factor 1 or 2]-N(5)-methyl-L-glutamine.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei142 – 1421S-adenosyl-L-methionineUniRule annotation
Binding sitei184 – 1841S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Release factor glutamine methyltransferaseUniRule annotation (EC:2.1.1.297UniRule annotation)
Short name:
RF MTaseUniRule annotation
Alternative name(s):
N5-glutamine methyltransferase PrmCUniRule annotation
Protein-(glutamine-N5) MTase PrmCUniRule annotation
Protein-glutamine N-methyltransferase PrmCUniRule annotation
Gene namesi
Name:prmCUniRule annotation
Ordered Locus Names:SCO5361
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Release factor glutamine methyltransferasePRO_0000414545Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO5361.

Structurei

3D structure databases

ProteinModelPortaliQ9K4E3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni184 – 1874Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EQY. Bacteria.
COG2890. LUCA.
HOGENOMiHOG000076276.
InParanoidiQ9K4E3.
KOiK02493.
OMAiWADAADH.
OrthoDBiEOG68Q0SZ.
PhylomeDBiQ9K4E3.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_02126. RF_methyltr_PrmC.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR004556. Modification_methylase_HemK.
IPR019874. Release_fac_Glu-N5_MeTfrase.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00536. hemK_fam. 1 hit.
TIGR03534. RF_mod_PrmC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9K4E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLLLAEVAQ ATQRLADAGV PSPRTDAEEL AAYLHGVKRG ELHTVPDADF
60 70 80 90 100
DARYWEVVAR REAREPLQHI TGRAYFRYLE LQVGPGVFVP RPETESVVGW
110 120 130 140 150
AIDAVRAMDV VEPCIVDLCT GSGAIALALA QEVPRSRVHA VELSEDALKW
160 170 180 190 200
TRRNMEGSRV DLRQGDALTA FPDLDGQVDL VVSNPPYIPL TEWEYVAPEA
210 220 230 240 250
RDHDPELALF SGEDGLDLIR GLERTAHRLL RPGGVVVVEH ADTQGGQVPW
260 270 280
IFTEERGWAD AADHPDLNNR PRFATARKAL P
Length:281
Mass (Da):31,073
Last modified:October 1, 2000 - v1
Checksum:i588A4217630BED5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939123 Genomic DNA. Translation: CAB94532.1.
RefSeqiNP_629500.1. NC_003888.3.
WP_003973636.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB94532; CAB94532; CAB94532.
GeneIDi1100801.
KEGGisco:SCO5361.
PATRICi23740570. VBIStrCoe124346_5441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939123 Genomic DNA. Translation: CAB94532.1.
RefSeqiNP_629500.1. NC_003888.3.
WP_003973636.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9K4E3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO5361.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB94532; CAB94532; CAB94532.
GeneIDi1100801.
KEGGisco:SCO5361.
PATRICi23740570. VBIStrCoe124346_5441.

Phylogenomic databases

eggNOGiENOG4105EQY. Bacteria.
COG2890. LUCA.
HOGENOMiHOG000076276.
InParanoidiQ9K4E3.
KOiK02493.
OMAiWADAADH.
OrthoDBiEOG68Q0SZ.
PhylomeDBiQ9K4E3.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_02126. RF_methyltr_PrmC.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR004556. Modification_methylase_HemK.
IPR019874. Release_fac_Glu-N5_MeTfrase.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00536. hemK_fam. 1 hit.
TIGR03534. RF_mod_PrmC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiPRMC_STRCO
AccessioniPrimary (citable) accession number: Q9K4E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.