Reviewed, UniProtKB/Swiss-Prot Q9K4A7 (AROA2_STRCO)

Names and origin

Protein names

Recommended name:
    3-phosphoshikimate 1-carboxyvinyltransferase 2
    EC=2.5.1.19
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthase 2
      Short name=EPSP synthase 2
      Short name=EPSPS 2

Gene names

Name:	aroA2
Ordered Locus Names:	SCO5212
ORF Names:	SC7E4.09c

Organism

Streptomyces coelicolor [Complete proteome] [HAMAP]

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 438	438	3-phosphoshikimate 1-carboxyvinyltransferase 2 HAMAP MF_00210		PRO_0000088302

Sequences

	Sequence		Length	Mass (Da)
	Q9K4A7-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 8373B568E6C5C353	FASTA	438	45,851
	10 20 30 40 50 60 MTVNPTHTAL WPAPHASGAV DATVHVPGSK SVTNRALVLA ALASEPGWLR RPLRSRDTLL 70 80 90 100 110 120 MAEALRTLGV EIEEGVGPEG TGEFWRVIPA GLRGPATVDV GNAGTVMRFL PPVATLADGA 130 140 150 160 170 180 VRFDGDPRSY ERPLHGVIDA LRVLGARIDD DGRGALPLTV HGGGALEGGP VEIDASSSSQ 190 200 210 220 230 240 FVSALLLSGP RFNQGVEVRH TGSALPSMPH IRMTVDMLRA VGAQVDTPES GGEPNVWRVT 250 260 270 280 290 300 PGALLGRDLT VEPDLSNAQP FLAAALVTGG KVVIPDWPSR TTQPGDRLRE IFTDMGGSCE 310 320 330 340 350 360 LTDFGLVFTG SGAIHGIDVD LSEVGELTPG IAAVAALADS PSTLRGVAHL RLHETDRLAA 370 380 390 400 410 420 LTKEINELGG DVTETADGLH IRPRRLHGGV FHTYDDHRMA TAGAVLGLAV EGVQIENVAT 430 TAKTLPDFPD LWTGMLGA

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL939122 Genomic DNA. Translation: CAB94597.1.
RefSeq	NP_629359.1.
3D structure databases
HSSP	HSSP built from PDB template 1G6S based on UniProtKB P07638.
ModBase	Search...
Genome annotation databases
GeneID	1100653.
GenomeReviews	Gene locus SCO5212 in contig AL645882_GR.
KEGG	sco:SCO5212.
NMPDR	fig|100226.1.peg.5167.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9K4A7.
OMA	HRMATAG.
Enzyme and pathway databases
BioCyc	SCOE100226:SCO5212-MON.
BRENDA	2.5.1.19. 1084.
Family and domain databases
HAMAP	MF_00210. [Tree]
InterPro	IPR016228. EPSP_synthase. IPR001986. EPSP_synthase_core. IPR006264. EPSP_synthase_subgroup. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
ProDom	PD001867. EPSP_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01356. aroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA2_STRCO

Accession

Primary (citable) accession number: Q9K4A7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2003
Last sequence update:	October 1, 2000
Last modified:	November 3, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)