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Protein

Peptide deformylase 4

Gene

def4

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi135IronUniRule annotation1
Metal bindingi177IronUniRule annotation1
Active sitei178UniRule annotation1
Metal bindingi181IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 4UniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDF 4UniRule annotation
Alternative name(s):
Polypeptide deformylase 4UniRule annotation
Gene namesi
Name:def4UniRule annotation
Ordered Locus Names:SCO5221
ORF Names:SC7E4.18
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000828551 – 216Peptide deformylase 4Add BLAST216

Proteomic databases

PRIDEiQ9K4A0

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO5221

Structurei

3D structure databases

ProteinModelPortaliQ9K4A0
SMRiQ9K4A0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z02 Bacteria
COG0242 LUCA
HOGENOMiHOG000243508
InParanoidiQ9K4A0
KOiK01462
OMAiHVGVVCN
OrthoDBiPOG091H02B0
PhylomeDBiQ9K4A0

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

Q9K4A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQQDTDQQH PGVLPVDDEG FVVDSQDCEE READWRGRGT SRPITVVGNP
60 70 80 90 100
VLHKECEDVT DFGEEFQQLV ADMFASQRTA EGVGLAANQI GVSKKVFVYD
110 120 130 140 150
CPDDEGVRHV GVVCNPRLVE LPADRRRLDD SNEGCLSVPT AYAPLARPDY
160 170 180 190 200
AEVTGQDEKG NPVKVRGTGY FARCLQHETD HLYGYLYIDR LSKRERKDAL
210
RQMAENEPRY PVVAND
Length:216
Mass (Da):24,184
Last modified:October 1, 2000 - v1
Checksum:i562FDF5C60732AAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939122 Genomic DNA Translation: CAB94606.1
RefSeqiNP_629368.1, NC_003888.3
WP_003973751.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB94606; CAB94606; CAB94606
GeneIDi1100662
KEGGisco:SCO5221
PATRICifig|100226.15.peg.5305

Similar proteinsi

Entry informationi

Entry nameiDEF4_STRCO
AccessioniPrimary (citable) accession number: Q9K4A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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