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Q9K4A0

- DEF4_STRCO

UniProt

Q9K4A0 - DEF4_STRCO

Protein

Peptide deformylase 4

Gene

def4

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi135 – 1351IronUniRule annotation
    Metal bindingi177 – 1771IronUniRule annotation
    Active sitei178 – 1781UniRule annotation
    Metal bindingi181 – 1811IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylase 4UniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDF 4UniRule annotation
    Alternative name(s):
    Polypeptide deformylase 4UniRule annotation
    Gene namesi
    Name:def4UniRule annotation
    Ordered Locus Names:SCO5221
    ORF Names:SC7E4.18
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 216216Peptide deformylase 4PRO_0000082855Add
    BLAST

    Proteomic databases

    PRIDEiQ9K4A0.

    Interactioni

    Protein-protein interaction databases

    STRINGi100226.SCO5221.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9K4A0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243508.
    KOiK01462.
    OMAiGYLYIDR.
    OrthoDBiEOG664CMF.
    PhylomeDBiQ9K4A0.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9K4A0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQQDTDQQH PGVLPVDDEG FVVDSQDCEE READWRGRGT SRPITVVGNP    50
    VLHKECEDVT DFGEEFQQLV ADMFASQRTA EGVGLAANQI GVSKKVFVYD 100
    CPDDEGVRHV GVVCNPRLVE LPADRRRLDD SNEGCLSVPT AYAPLARPDY 150
    AEVTGQDEKG NPVKVRGTGY FARCLQHETD HLYGYLYIDR LSKRERKDAL 200
    RQMAENEPRY PVVAND 216
    Length:216
    Mass (Da):24,184
    Last modified:October 1, 2000 - v1
    Checksum:i562FDF5C60732AAF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939122 Genomic DNA. Translation: CAB94606.1.
    RefSeqiNP_629368.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB94606; CAB94606; CAB94606.
    GeneIDi1100662.
    KEGGisco:SCO5221.
    PATRICi23740294. VBIStrCoe124346_5305.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939122 Genomic DNA. Translation: CAB94606.1 .
    RefSeqi NP_629368.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9K4A0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO5221.

    Proteomic databases

    PRIDEi Q9K4A0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB94606 ; CAB94606 ; CAB94606 .
    GeneIDi 1100662.
    KEGGi sco:SCO5221.
    PATRICi 23740294. VBIStrCoe124346_5305.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243508.
    KOi K01462.
    OMAi GYLYIDR.
    OrthoDBi EOG664CMF.
    PhylomeDBi Q9K4A0.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiDEF4_STRCO
    AccessioniPrimary (citable) accession number: Q9K4A0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3