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Protein

Putative cytochrome c oxidase subunit 1-beta

Gene

ctaD2

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu2+By similarityNote: Binds 1 copper B ion per subunit.By similarity
  • hemeBy similarityNote: Binds 2 heme groups per subunit.By similarity

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi100Iron (heme A axial ligand)By similarity1
Metal bindingi278Copper BBy similarity1
Metal bindingi282Copper BBy similarity1
Metal bindingi327Copper BBy similarity1
Metal bindingi328Copper BBy similarity1
Metal bindingi411Iron (heme A3 axial ligand)By similarity1
Metal bindingi413Iron (heme A axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cytochrome c oxidase subunit 1-beta (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1-beta
Cytochrome c oxidase polypeptide I-beta
Gene namesi
Name:ctaD2
Ordered Locus Names:SCO7234
ORF Names:SC2H12.33
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21
Transmembranei490 – 510HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834531 – 573Putative cytochrome c oxidase subunit 1-betaAdd BLAST573

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki278 ↔ 2821'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PRIDEiQ9K451

Interactioni

Subunit structurei

Associates with subunits II, III and IV to form cytochrome c oxidase.By similarity

Protein-protein interaction databases

STRINGi100226.SCO7234

Structurei

3D structure databases

ProteinModelPortaliQ9K451
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ9 Bacteria
COG0843 LUCA
HOGENOMiHOG000085275
InParanoidiQ9K451
KOiK02274
OMAiPPAHGNW
OrthoDBiPOG091H042R
PhylomeDBiQ9K451

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR014241 Cyt_c_oxidase_su1_bac
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
TIGRFAMsiTIGR02891 CtaD_CoxA, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9K451-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVGLSPRRL GTLRRMAVDR RTKSPRRTPA RQRTNRTLGR ALVRWATTTD
60 70 80 90 100
HKVIGHLYLA TSFGFFLLGG VLAMLMRSEL ARPGLQLFSN EQYNQLFTVH
110 120 130 140 150
GTIMMLLFAT PLFAGFTNVI MPLQIGAPDL AFPRLNALSY WMYLFGGLMV
160 170 180 190 200
VSGFLTPGGA ASFGWFAYAP LNSATFSPGP GGDLWTMGLV VSGVSTTLSA
210 220 230 240 250
VNFISTIICL RAPGMTMFRM PIFTWNILFT SILVLPAFPV LTAALLMLEA
260 270 280 290 300
DRKFGAHVFD AANGGALLWQ HLFWFFGHPE VYIVALPFFG IVTEIIPVFS
310 320 330 340 350
RKPIFGYVSL VGATIAITFL SAVVWAHHMF ATGAVLLPFF SLMSFLIAVP
360 370 380 390 400
TGVKFFNWIG TMIRGSLSFE TPMLWACGFL VTFLLGGMSG VLIASPPLDF
410 420 430 440 450
HLTDSYFIVA HLHYVLFGTV VFAMFAGFYF WWPKFTGKLL DERLGKIHFW
460 470 480 490 500
TLFVGFQTTF LVQHWLGEQG MPRRYADYLA ADGFTTLNTI SSIGAFLLGL
510 520 530 540 550
STLPFLYNVW RTHQYGEKVG RDDPWGYGRS LEWATSSPPP RHNFTSLPRI
560 570
RSESPAFDLH HPDVTRHDQR HVQ
Length:573
Mass (Da):64,041
Last modified:October 1, 2000 - v1
Checksum:i1FC5DC79FD6DA220
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939130 Genomic DNA Translation: CAB94657.1
RefSeqiNP_631290.1, NC_003888.3
WP_003971911.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB94657; CAB94657; CAB94657
GeneIDi1102672
KEGGisco:SCO7234
PATRICifig|100226.15.peg.7334

Similar proteinsi

Entry informationi

Entry nameiCOX1B_STRCO
AccessioniPrimary (citable) accession number: Q9K451
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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