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Q9K451 (COX1B_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative cytochrome c oxidase subunit 1-beta

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 1-beta
Cytochrome c oxidase polypeptide I-beta
Gene names
Name:ctaD2
Ordered Locus Names:SCO7234
ORF Names:SC2H12.33
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group

Protein attributes

Sequence length573 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Binds 1 copper B per subunit By similarity.

Binds 2 heme groups per subunit By similarity.

Pathway

Energy metabolism; oxidative phosphorylation.

Subunit structure

Associates with subunits II, III and IV to form cytochrome c oxidase By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 573573Putative cytochrome c oxidase subunit 1-beta
PRO_0000183453

Regions

Transmembrane53 – 7321Helical; Potential
Transmembrane103 – 12321Helical; Potential
Transmembrane141 – 16121Helical; Potential
Transmembrane188 – 20821Helical; Potential
Transmembrane227 – 24721Helical; Potential
Transmembrane272 – 29221Helical; Potential
Transmembrane304 – 32421Helical; Potential
Transmembrane329 – 34921Helical; Potential
Transmembrane373 – 39321Helical; Potential
Transmembrane412 – 43221Helical; Potential
Transmembrane447 – 46721Helical; Potential
Transmembrane490 – 51021Helical; Potential

Sites

Metal binding1001Iron (heme A axial ligand) By similarity
Metal binding2781Copper B By similarity
Metal binding2821Copper B By similarity
Metal binding3271Copper B By similarity
Metal binding3281Copper B By similarity
Metal binding4111Iron (heme A3 axial ligand) By similarity
Metal binding4131Iron (heme A axial ligand) By similarity

Amino acid modifications

Cross-link278 ↔ 2821'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9K451 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 1FC5DC79FD6DA220

FASTA57364,041
        10         20         30         40         50         60 
MVVGLSPRRL GTLRRMAVDR RTKSPRRTPA RQRTNRTLGR ALVRWATTTD HKVIGHLYLA 

        70         80         90        100        110        120 
TSFGFFLLGG VLAMLMRSEL ARPGLQLFSN EQYNQLFTVH GTIMMLLFAT PLFAGFTNVI 

       130        140        150        160        170        180 
MPLQIGAPDL AFPRLNALSY WMYLFGGLMV VSGFLTPGGA ASFGWFAYAP LNSATFSPGP 

       190        200        210        220        230        240 
GGDLWTMGLV VSGVSTTLSA VNFISTIICL RAPGMTMFRM PIFTWNILFT SILVLPAFPV 

       250        260        270        280        290        300 
LTAALLMLEA DRKFGAHVFD AANGGALLWQ HLFWFFGHPE VYIVALPFFG IVTEIIPVFS 

       310        320        330        340        350        360 
RKPIFGYVSL VGATIAITFL SAVVWAHHMF ATGAVLLPFF SLMSFLIAVP TGVKFFNWIG 

       370        380        390        400        410        420 
TMIRGSLSFE TPMLWACGFL VTFLLGGMSG VLIASPPLDF HLTDSYFIVA HLHYVLFGTV 

       430        440        450        460        470        480 
VFAMFAGFYF WWPKFTGKLL DERLGKIHFW TLFVGFQTTF LVQHWLGEQG MPRRYADYLA 

       490        500        510        520        530        540 
ADGFTTLNTI SSIGAFLLGL STLPFLYNVW RTHQYGEKVG RDDPWGYGRS LEWATSSPPP 

       550        560        570 
RHNFTSLPRI RSESPAFDLH HPDVTRHDQR HVQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939130 Genomic DNA. Translation: CAB94657.1.
RefSeqNP_631290.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9K451.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO7234.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB94657; CAB94657; CAB94657.
GeneID1102672.
KEGGsco:SCO7234.
PATRIC23744383. VBIStrCoe124346_7334.

Phylogenomic databases

eggNOGCOG0843.
HOGENOMHOG000085275.
KOK02274.
OMAILNIWIL.
OrthoDBEOG6B35XR.
PhylomeDBQ9K451.

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
TIGRFAMsTIGR02891. CtaD_CoxA. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1B_STRCO
AccessionPrimary (citable) accession number: Q9K451
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways