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Q9K451

- COX1B_STRCO

UniProt

Q9K451 - COX1B_STRCO

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Protein
Putative cytochrome c oxidase subunit 1-beta
Gene
ctaD2, SCO7234, SC2H12.33
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 1 copper B per subunit By similarity.
Binds 2 heme groups per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi100 – 1001Iron (heme A axial ligand) By similarity
Metal bindingi278 – 2781Copper B By similarity
Metal bindingi282 – 2821Copper B By similarity
Metal bindingi327 – 3271Copper B By similarity
Metal bindingi328 – 3281Copper B By similarity
Metal bindingi411 – 4111Iron (heme A3 axial ligand) By similarity
Metal bindingi413 – 4131Iron (heme A axial ligand) By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cytochrome c oxidase subunit 1-beta (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1-beta
Cytochrome c oxidase polypeptide I-beta
Gene namesi
Name:ctaD2
Ordered Locus Names:SCO7234
ORF Names:SC2H12.33
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei53 – 7321Helical; Reviewed prediction
Add
BLAST
Transmembranei103 – 12321Helical; Reviewed prediction
Add
BLAST
Transmembranei141 – 16121Helical; Reviewed prediction
Add
BLAST
Transmembranei188 – 20821Helical; Reviewed prediction
Add
BLAST
Transmembranei227 – 24721Helical; Reviewed prediction
Add
BLAST
Transmembranei272 – 29221Helical; Reviewed prediction
Add
BLAST
Transmembranei304 – 32421Helical; Reviewed prediction
Add
BLAST
Transmembranei329 – 34921Helical; Reviewed prediction
Add
BLAST
Transmembranei373 – 39321Helical; Reviewed prediction
Add
BLAST
Transmembranei412 – 43221Helical; Reviewed prediction
Add
BLAST
Transmembranei447 – 46721Helical; Reviewed prediction
Add
BLAST
Transmembranei490 – 51021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Putative cytochrome c oxidase subunit 1-beta
PRO_0000183453Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki278 ↔ 2821'-histidyl-3'-tyrosine (His-Tyr) By similarity

Interactioni

Subunit structurei

Associates with subunits II, III and IV to form cytochrome c oxidase By similarity.

Protein-protein interaction databases

STRINGi100226.SCO7234.

Structurei

3D structure databases

ProteinModelPortaliQ9K451.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085275.
KOiK02274.
OMAiILNIWIL.
OrthoDBiEOG6B35XR.
PhylomeDBiQ9K451.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9K451-1 [UniParc]FASTAAdd to Basket

« Hide

MVVGLSPRRL GTLRRMAVDR RTKSPRRTPA RQRTNRTLGR ALVRWATTTD    50
HKVIGHLYLA TSFGFFLLGG VLAMLMRSEL ARPGLQLFSN EQYNQLFTVH 100
GTIMMLLFAT PLFAGFTNVI MPLQIGAPDL AFPRLNALSY WMYLFGGLMV 150
VSGFLTPGGA ASFGWFAYAP LNSATFSPGP GGDLWTMGLV VSGVSTTLSA 200
VNFISTIICL RAPGMTMFRM PIFTWNILFT SILVLPAFPV LTAALLMLEA 250
DRKFGAHVFD AANGGALLWQ HLFWFFGHPE VYIVALPFFG IVTEIIPVFS 300
RKPIFGYVSL VGATIAITFL SAVVWAHHMF ATGAVLLPFF SLMSFLIAVP 350
TGVKFFNWIG TMIRGSLSFE TPMLWACGFL VTFLLGGMSG VLIASPPLDF 400
HLTDSYFIVA HLHYVLFGTV VFAMFAGFYF WWPKFTGKLL DERLGKIHFW 450
TLFVGFQTTF LVQHWLGEQG MPRRYADYLA ADGFTTLNTI SSIGAFLLGL 500
STLPFLYNVW RTHQYGEKVG RDDPWGYGRS LEWATSSPPP RHNFTSLPRI 550
RSESPAFDLH HPDVTRHDQR HVQ 573
Length:573
Mass (Da):64,041
Last modified:October 1, 2000 - v1
Checksum:i1FC5DC79FD6DA220
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939130 Genomic DNA. Translation: CAB94657.1.
RefSeqiNP_631290.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB94657; CAB94657; CAB94657.
GeneIDi1102672.
KEGGisco:SCO7234.
PATRICi23744383. VBIStrCoe124346_7334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939130 Genomic DNA. Translation: CAB94657.1 .
RefSeqi NP_631290.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9K451.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO7234.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB94657 ; CAB94657 ; CAB94657 .
GeneIDi 1102672.
KEGGi sco:SCO7234.
PATRICi 23744383. VBIStrCoe124346_7334.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085275.
KOi K02274.
OMAi ILNIWIL.
OrthoDBi EOG6B35XR.
PhylomeDBi Q9K451.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiCOX1B_STRCO
AccessioniPrimary (citable) accession number: Q9K451
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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