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Q9K451

- COX1B_STRCO

UniProt

Q9K451 - COX1B_STRCO

Protein

Putative cytochrome c oxidase subunit 1-beta

Gene

ctaD2

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Binds 1 copper B per subunit.By similarity
    Binds 2 heme groups per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi100 – 1001Iron (heme A axial ligand)By similarity
    Metal bindingi278 – 2781Copper BBy similarity
    Metal bindingi282 – 2821Copper BBy similarity
    Metal bindingi327 – 3271Copper BBy similarity
    Metal bindingi328 – 3281Copper BBy similarity
    Metal bindingi411 – 4111Iron (heme A3 axial ligand)By similarity
    Metal bindingi413 – 4131Iron (heme A axial ligand)By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. electron transport chain Source: InterPro
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative cytochrome c oxidase subunit 1-beta (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 1-beta
    Cytochrome c oxidase polypeptide I-beta
    Gene namesi
    Name:ctaD2
    Ordered Locus Names:SCO7234
    ORF Names:SC2H12.33
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 573573Putative cytochrome c oxidase subunit 1-betaPRO_0000183453Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki278 ↔ 2821'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Interactioni

    Subunit structurei

    Associates with subunits II, III and IV to form cytochrome c oxidase.By similarity

    Protein-protein interaction databases

    STRINGi100226.SCO7234.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9K451.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei227 – 24721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei329 – 34921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei373 – 39321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei412 – 43221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei447 – 46721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei490 – 51021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0843.
    HOGENOMiHOG000085275.
    KOiK02274.
    OMAiILNIWIL.
    OrthoDBiEOG6B35XR.
    PhylomeDBiQ9K451.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9K451-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVGLSPRRL GTLRRMAVDR RTKSPRRTPA RQRTNRTLGR ALVRWATTTD    50
    HKVIGHLYLA TSFGFFLLGG VLAMLMRSEL ARPGLQLFSN EQYNQLFTVH 100
    GTIMMLLFAT PLFAGFTNVI MPLQIGAPDL AFPRLNALSY WMYLFGGLMV 150
    VSGFLTPGGA ASFGWFAYAP LNSATFSPGP GGDLWTMGLV VSGVSTTLSA 200
    VNFISTIICL RAPGMTMFRM PIFTWNILFT SILVLPAFPV LTAALLMLEA 250
    DRKFGAHVFD AANGGALLWQ HLFWFFGHPE VYIVALPFFG IVTEIIPVFS 300
    RKPIFGYVSL VGATIAITFL SAVVWAHHMF ATGAVLLPFF SLMSFLIAVP 350
    TGVKFFNWIG TMIRGSLSFE TPMLWACGFL VTFLLGGMSG VLIASPPLDF 400
    HLTDSYFIVA HLHYVLFGTV VFAMFAGFYF WWPKFTGKLL DERLGKIHFW 450
    TLFVGFQTTF LVQHWLGEQG MPRRYADYLA ADGFTTLNTI SSIGAFLLGL 500
    STLPFLYNVW RTHQYGEKVG RDDPWGYGRS LEWATSSPPP RHNFTSLPRI 550
    RSESPAFDLH HPDVTRHDQR HVQ 573
    Length:573
    Mass (Da):64,041
    Last modified:October 1, 2000 - v1
    Checksum:i1FC5DC79FD6DA220
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939130 Genomic DNA. Translation: CAB94657.1.
    RefSeqiNP_631290.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB94657; CAB94657; CAB94657.
    GeneIDi1102672.
    KEGGisco:SCO7234.
    PATRICi23744383. VBIStrCoe124346_7334.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939130 Genomic DNA. Translation: CAB94657.1 .
    RefSeqi NP_631290.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9K451.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO7234.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB94657 ; CAB94657 ; CAB94657 .
    GeneIDi 1102672.
    KEGGi sco:SCO7234.
    PATRICi 23744383. VBIStrCoe124346_7334.

    Phylogenomic databases

    eggNOGi COG0843.
    HOGENOMi HOG000085275.
    KOi K02274.
    OMAi ILNIWIL.
    OrthoDBi EOG6B35XR.
    PhylomeDBi Q9K451.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiCOX1B_STRCO
    AccessioniPrimary (citable) accession number: Q9K451
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3