Q9K407 (UPPP2_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase 2
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2

Gene names

Name:	uppP2
Synonyms:	bacA2, upk2
Ordered Locus Names:	SCO1326
ORF Names:	2SCG61.08

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	Undecaprenyl-diphosphatase 2 HAMAP MF_01006		PRO_0000151212
Regions
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	85 – 105	21	Helical; Potential
	Transmembrane	118 – 138	21	Helical; Potential
	Transmembrane	198 – 218	21	Helical; Potential
	Transmembrane	231 – 251	21	Helical; Potential
	Transmembrane	262 – 282	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9K407 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: AB24C9578D4E1F51	FASTA	291	31,437
	10 20 30 40 50 60 MSWFESLVLG LVQGLTEFLP VSSSAHLRLT AAFSGWHDPG AAFTAITQIG TEAAVLIYFR 70 80 90 100 110 120 KDIGRIIAAW TRSLTDKSMR HDPDARMGWL VIVGSIPIGV LGLTLKDQIE GPFRDLRITA 130 140 150 160 170 180 TMLIVVGVII GIADRMAARD EKGGRHRAPQ QRKELENLGV RDGLIYGLCQ AAALIPGVSR 190 200 210 220 230 240 SGATISGGLF MGYRREAAAR YSFLLAIPAV LASGVFELKD AMESDHVSWG PTLFATVIAF 250 260 270 280 290 ATGYVVIAWF MKFISTKSFM PFVWYRIALG IVIIVLVSVG VLSPHAAESG G

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939108 Genomic DNA. Translation: CAB95783.1.
RefSeq	NP_625611.1. NC_003888.3.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1096749.
GenomeReviews	Gene locus SCO1326 in contig AL645882_GR.
KEGG	sco:SCO1326.
NMPDR	fig|100226.1.peg.1293.
PATRIC	23732214. VBIStrCoe124346_1330.
Phylogenomic databases
HOGENOM	HBG391969.
OMA	IRTGARN.
PhylomeDB	Q9K407.
ProtClustDB	PRK12554.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
KO	K06153.
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. Undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP2_STRCO

Accession

Primary (citable) accession number: Q9K407

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program