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Q9K407

- UPPP2_STRCO

UniProt

Q9K407 - UPPP2_STRCO

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Protein

Undecaprenyl-diphosphatase 2

Gene

uppP2

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 2UniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance protein 2UniRule annotation
Undecaprenyl pyrophosphate phosphatase 2UniRule annotation
Gene namesi
Name:uppP2UniRule annotation
Synonyms:bacA2, upk2
Ordered Locus Names:SCO1326
ORF Names:2SCG61.08
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921HelicalUniRule annotationAdd
BLAST
Transmembranei85 – 10521HelicalUniRule annotationAdd
BLAST
Transmembranei118 – 13821HelicalUniRule annotationAdd
BLAST
Transmembranei198 – 21821HelicalUniRule annotationAdd
BLAST
Transmembranei231 – 25121HelicalUniRule annotationAdd
BLAST
Transmembranei262 – 28221HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Undecaprenyl-diphosphatase 2PRO_0000151212Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO1326.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
InParanoidiQ9K407.
KOiK06153.
OMAiIEGPFRD.
OrthoDBiEOG6QP13M.
PhylomeDBiQ9K407.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9K407-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWFESLVLG LVQGLTEFLP VSSSAHLRLT AAFSGWHDPG AAFTAITQIG
60 70 80 90 100
TEAAVLIYFR KDIGRIIAAW TRSLTDKSMR HDPDARMGWL VIVGSIPIGV
110 120 130 140 150
LGLTLKDQIE GPFRDLRITA TMLIVVGVII GIADRMAARD EKGGRHRAPQ
160 170 180 190 200
QRKELENLGV RDGLIYGLCQ AAALIPGVSR SGATISGGLF MGYRREAAAR
210 220 230 240 250
YSFLLAIPAV LASGVFELKD AMESDHVSWG PTLFATVIAF ATGYVVIAWF
260 270 280 290
MKFISTKSFM PFVWYRIALG IVIIVLVSVG VLSPHAAESG G
Length:291
Mass (Da):31,437
Last modified:October 1, 2000 - v1
Checksum:iAB24C9578D4E1F51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939108 Genomic DNA. Translation: CAB95783.1.
RefSeqiNP_625611.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB95783; CAB95783; CAB95783.
GeneIDi1096749.
KEGGisco:SCO1326.
PATRICi23732214. VBIStrCoe124346_1330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939108 Genomic DNA. Translation: CAB95783.1 .
RefSeqi NP_625611.1. NC_003888.3.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO1326.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB95783 ; CAB95783 ; CAB95783 .
GeneIDi 1096749.
KEGGi sco:SCO1326.
PATRICi 23732214. VBIStrCoe124346_1330.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
InParanoidi Q9K407.
KOi K06153.
OMAi IEGPFRD.
OrthoDBi EOG6QP13M.
PhylomeDBi Q9K407.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiUPPP2_STRCO
AccessioniPrimary (citable) accession number: Q9K407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3