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Q9K3R6 (ISPE_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
Short name=CMK
EC=2.7.1.148
Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Gene names
Name:ispE
Ordered Locus Names:SCO3148
ORF Names:SCE66.27c
OrganismStreptomyces coelicolor
Taxonomic identifier1902 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP MF_00061

Catalytic activity

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00061

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP MF_00061

Sequence similarities

Belongs to the GHMP kinase family. IspE subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2992994-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP MF_00061
PRO_0000189272

Regions

Nucleotide binding96 – 10611ATP Potential

Sites

Active site101 By similarity
Active site1381 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9K3R6 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 8BE62BD0B04890D0

FASTA29929,814
        10         20         30         40         50         60 
MSVTVRVPAK VNVQLAVGAA RPDGFHDLAN VFLAVSLYDE VTATPAADGL RVTCEGPDAG 

        70         80         90        100        110        120 
QVPLDRTNLA ARAAEALAAR YGRAPDVHLH IAKDIPVAGG MAGGSADGAG ALLACDALWG 

       130        140        150        160        170        180 
TGASREELLE ICAGLGSDVP FSLVGGAALG TGRGERLAEL EVGGDFHWVF ALAARGLSTP 

       190        200        210        220        230        240 
AVFREFDRLG EGLDLPEPVA DQAVLDALAK GDAAALAVAV TNDLQPAALS LFPELSDTLA 

       250        260        270        280        290 
AGRAAGALAA LVSGSGPTTA FLATDARSAS DIAGVLRASG TCRDVRTAVG AAAGATVLD

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL939115 Genomic DNA. Translation: CAB95941.1.
RefSeqNP_627365.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9K3R6.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1098582.
GenomeReviewsGene locus SCO3148 in contig AL645882_GR.
KEGGsco:SCO3148.
NMPDRfig|100226.1.peg.3109.
PATRIC23736038. VBIStrCoe124346_3209.

Phylogenomic databases

HOGENOMHBG734593.
OMAVSTAEVY.
PhylomeDBQ9K3R6.
ProtClustDBPRK03188.

Family and domain databases

HAMAPMF_00061. IspE.
[Tree]
InterProIPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
Gene3DG3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KOK00919.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF010376. IspE. 1 hit.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00154. IspE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameISPE_STRCO
AccessionPrimary (citable) accession number: Q9K3R6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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