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Q9K303

- BLAB3_ELIME

UniProt

Q9K303 - BLAB3_ELIME

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Protein
Carbapenem-hydrolyzing beta-lactamase BlaB-3
Gene
blaB3, blaB
Organism
Elizabethkingia meningoseptica (Chryseobacterium meningosepticum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes penicillins, cephalosporins (including cefoxitin), carbapenems and 6-beta-iodopenicillanate By similarity.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi98 – 981Zinc 1 By similarity
Metal bindingi100 – 1001Zinc 1 By similarity
Metal bindingi102 – 1021Zinc 2 By similarity
Metal bindingi161 – 1611Zinc 1 By similarity
Metal bindingi180 – 1801Zinc 2 By similarity
Metal bindingi222 – 2221Zinc 2 By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Carbapenem-hydrolyzing beta-lactamase BlaB-3 (EC:3.5.2.6)
Short name:
CHbetaL-3
Alternative name(s):
Class B carbapenemase BlaB-3
Gene namesi
Name:blaB3
Synonyms:blaB
OrganismiElizabethkingia meningoseptica (Chryseobacterium meningosepticum)
Taxonomic identifieri238 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeElizabethkingia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 By similarity
Add
BLAST
Chaini23 – 249227Carbapenem-hydrolyzing beta-lactamase BlaB-3
PRO_0000016951Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9K303.
SMRiQ9K303. Positions 27-245.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
PROSITEiPS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9K303-1 [UniParc]FASTAAdd to Basket

« Hide

MLKKIKISLI LALGLTSLQA FGQENPDVKI EKLKDNLYVY TTYNTFNGTK    50
YAANAVYLVT DKGVVVIDCP WGEDKFKSFT DEIYKKHGKK VIINIATHSH 100
DDRAGGLEYF GKIGAKTYST KMTDSILAKE NKPRAQYTFD NNKSFKVGKS 150
EFQVYYPGKG HTADNVVVWF PKEKVLVGGC IIKSADSKDL GYIGEAYVND 200
WTQSVHNIQQ KFSGAQYVVA GHDDWKDQTS IQHTLDLISE YQQKQKASN 249
Length:249
Mass (Da):28,044
Last modified:October 1, 2000 - v1
Checksum:i65C437D44A143276
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF189299 Genomic DNA. Translation: AAF89155.1.
AF189301 Genomic DNA. Translation: AAF89157.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF189299 Genomic DNA. Translation: AAF89155.1 .
AF189301 Genomic DNA. Translation: AAF89157.1 .

3D structure databases

ProteinModelPortali Q9K303.
SMRi Q9K303. Positions 27-245.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.15.10. 1 hit.
InterProi IPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view ]
Pfami PF00753. Lactamase_B. 1 hit.
[Graphical view ]
SMARTi SM00849. Lactamase_B. 1 hit.
[Graphical view ]
SUPFAMi SSF56281. SSF56281. 1 hit.
PROSITEi PS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular and biochemical heterogeneity of class B carbapenem-hydrolyzing beta-lactamases in Chryseobacterium meningosepticum."
    Bellais S., Aubert D., Naas T., Nordmann P.
    Antimicrob. Agents Chemother. 44:1878-1886(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13255 / CIP 6059 / CCUG 4321 / LMG 12873 / NCTC 10586 and GEO.

Entry informationi

Entry nameiBLAB3_ELIME
AccessioniPrimary (citable) accession number: Q9K303
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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