Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9K1P9 (GLMS_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

EC=2.6.1.16
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene names
Name:glmS
Ordered Locus Names:NMB0031
OrganismNeisseria meningitidis serogroup B (strain MC58) [Reference proteome] [HAMAP]
Taxonomic identifier122586 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length612 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity. HAMAP-Rule MF_00164

Catalytic activity

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate. HAMAP-Rule MF_00164

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00164

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00164.

Sequence similarities

Contains 1 glutamine amidotransferase type-2 domain.

Contains 2 SIS domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 612611Glutamine--fructose-6-phosphate aminotransferase [isomerizing] HAMAP-Rule MF_00164
PRO_0000135361

Regions

Domain2 – 220219Glutamine amidotransferase type-2
Domain288 – 428141SIS 1
Domain461 – 602142SIS 2

Sites

Active site21Nucleophile; for GATase activity By similarity
Active site6071For Fru-6P isomerization activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9K1P9 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 0FE3788D70A19CF4

FASTA61266,619
        10         20         30         40         50         60 
MCGIVGAIRA HHNVVDFLTD GLKRLEYRGY DSSGIAVNTD GKIKRVRRVG RVQLMEDAAR 

        70         80         90        100        110        120 
EKGISGGIGI GHTRWATHGG VTEPNAHPHI SGGMIAVVHN GIIENFESER KRLEGLGYRF 

       130        140        150        160        170        180 
ESQTDTEVIA HSINHEYAQN GGRLFEAVQE AVKRFHGAYA IAVIAQDKPD ELVVARMGCP 

       190        200        210        220        230        240 
LLVALGDDET FIASDVSAVI AFTRRVAYLE DGDIALLASD GIKRLTDKNG LPAERKVKVS 

       250        260        270        280        290        300 
ELSLASLELG LYSHFMQKEI HEQPRAIADT AEVFLDGGFI PENFGKDAKS VFESIRSVKI 

       310        320        330        340        350        360 
LACGTSYYAA LTAKYWLESI AKIPSDVEIA SEYRYRSVIA DSDQLVITIS QSGETLDTME 

       370        380        390        400        410        420 
ALKYAKSLGH RHSLSICNVM ESALPRESSL VLYTRAGAEI GVASTKAFTT QLVALFGLAV 

       430        440        450        460        470        480 
TLAKVRGLVS EEDEARYTEE LRQLPGSVQH ALNLEPQIAA WAQQFAKKTS ALFLGRGIHY 

       490        500        510        520        530        540 
PIALEGALKL KEITYIHAEA YPAGELKHGP LALVDENMPV VVIAPNDSLL DKVKANMQEV 

       550        560        570        580        590        600 
GARGGELFVF ADLDSNFNAT EGVHVIRAPR HVGKLSPVVH TIPVQLLAYH TALARGTDVD 

       610 
KPRNLAKSVT VE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE002098 Genomic DNA. Translation: AAF40502.1.
PIRB81246.
RefSeqNP_273097.1. NC_003112.2.

3D structure databases

ProteinModelPortalQ9K1P9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING122586.NMB0031.

Protein family/group databases

MEROPSC44.971.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF40502; AAF40502; NMB0031.
GeneID902134.
KEGGnme:NMB0031.
PATRIC20355011. VBINeiMen85645_0042.

Phylogenomic databases

eggNOGCOG0449.
HOGENOMHOG000258896.
KOK00820.
OMALGIGENF.
OrthoDBEOG6KT2Q1.
ProtClustDBPRK00331.

Enzyme and pathway databases

BioCycNMEN122586:GHGG-32-MONOMER.

Family and domain databases

HAMAPMF_00164. GlmS.
InterProIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR001347. SIS.
[Graphical view]
PANTHERPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
TIGRFAMsTIGR01135. glmS. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLMS_NEIMB
AccessionPrimary (citable) accession number: Q9K1P9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families