Pyrroline-5-carboxylate reductase - Neisseria meningitidis serogroup B

Preferred order of sections

Names and origin

Protein names

Submitted name:
Pyrroline-5-carboxylate reductase EMBL AAF40524.1
EC=1.5.1.2 EMBL AAF40524.1

Gene names

Name:	proC EMBL AAF40524.1
Ordered Locus Names:	NMB0055

Organism

Neisseria meningitidis serogroup B

Taxonomic identifier

491 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	NADP PDB 2AG8 Nucleotide-binding PDB 2AG8
Molecular function	Oxidoreductase EMBL AAF40524.1
Technical term	3D-structure PDB 2AG8 PDB 1YQG Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Nucleotide binding

10 – 11

2

NADP PDB 2AG8

Nucleotide binding

31 – 36

6

NADP PDB 2AG8

Nucleotide binding

87 – 89

3

NADP PDB 2AG8

Sites

Binding site

65

1

NADP; via carbonyl oxygen PDB 2AG8

Binding site

111

1

NADP PDB 2AG8

Sequences

Sequence

Length

Mass (Da)

Tools

Q9K1N1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: A8DE0DD667167A1C
Show »

FASTA

263

28,341

        10         20         30         40         50         60 
MNVYFLGGGN MAAAVAGGLV KQGGYRIYIA NRGAEKRERL EKELGVETSA TLPELHSDDV 

        70         80         90        100        110        120 
LILAVKPQDM EAACKNIRTN GALVLSVAAG LSVGTLSRYL GGTRRIVRVM PNTPGKIGLG 

       130        140        150        160        170        180 
VSGMYAEAEV SETDRRIADR IMKSVGLTVW LDDEEKMHGI TGISGSGPAY VFYLLDALQN 

       190        200        210        220        230        240 
AAIRQGFDMA EARALSLATF KGAVALAEQT GEDFEKLQKN VTSKGGTTHE AVEAFRRHRV 

       250        260 
AEAISEGVCA CVRRSQEMER QYQ

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58." Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O. Venter J.C. Science 287:1809-1815(2000) [PubMed: 10710307] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC58 / Serogroup B.
[2]	"Crystal structures of delta1-pyrroline-5-carboxylate reductase from human pathogens Neisseria meningitides and Streptococcus pyogenes." Nocek B., Chang C., Li H., Lezondra L., Holzle D., Collart F., Joachimiak A. J. Mol. Biol. 354:91-106(2005) [PubMed: 16233902] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH NADP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE002098 Genomic DNA. Translation: AAF40524.1.

PIR

E81243.

RefSeq

NP_273120.1. NC_003112.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1YQG	X-ray	1.90	A	1-263	[»]
2AG8	X-ray	2.10	A	1-263	[»]

ProteinModelPortal

Q9K1N1.

SMR

Q9K1N1. Positions 1-263.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBNEIT00000010821; EBNEIP00000010441; EBNEIG00000010821.

GeneID

902157.

GenomeReviews

Gene locus NMB0055 in contig AE002098_GR.

KEGG

nme:NMB0055.

NMPDR

fig|122586.1.peg.54.

PATRIC

20355103. VBINeiMen85645_0089.

TIGR

NMB0055.

Phylogenomic databases

GeneTree

EBGT00050000021402.

HOGENOM

HBG726602.

OMA

RYLGGTR.

ProtClustDB

CLSK877374.

Family and domain databases

InterPro

IPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR004455. NADP_OxRdtase_F420.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view]

Gene3D

G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.

KO

K00286.

PANTHER

PTHR11645. P5CR. 1 hit.

Pfam

PF03807. F420_oxidored. 1 hit.
[Graphical view]

PIRSF

PIRSF000193. Pyrrol-5-carb_rd. 1 hit.

SUPFAM

SSF48179. 6DGDH_C_like. 1 hit.

TIGRFAMs

TIGR00112. ProC. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q9K1N1_NEIMB

Accession

Primary (citable) accession number: Q9K1N1

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	December 14, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)