Q9K1K9 (PYRI_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase regulatory chain

Gene names

Name:	pyrI
Ordered Locus Names:	NMB0107

Organism

Neisseria meningitidis serogroup B

Taxonomic identifier

491 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	152 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in allosteric regulation of aspartate carbamoyltransferase By similarity. HAMAP MF_00002
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00002
Subunit structure	Contains catalytic and regulatory chains.
Sequence similarities	Belongs to the pyrI family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	aspartate carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 152	152	Aspartate carbamoyltransferase regulatory chain HAMAP MF_00002		PRO_0000142308
Sites
	Metal binding	108	1	Zinc By similarity
	Metal binding	113	1	Zinc By similarity
	Metal binding	137	1	Zinc By similarity
	Metal binding	140	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9K1K9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 7E838D72FF83A73E	FASTA	152	16,904
	10 20 30 40 50 60 METPKLSVEA IEKGTVIDHI PAGRGLTILR QFKLLHYGNA VTVGFNLPSK TQGSKDIIKI 70 80 90 100 110 120 KGVCLDDKAA DRLALFAPEA VVNTIDNFKV VQKRHLNLPD EIAEVFRCPN TNCAGHGEPV 130 140 150 KSRFYVKKHN GQTRLKCHYC EKTYSRDSVA EA

References

[1]

"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58." Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O. , Fleischmann R.D., Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., Venter J.C. Science 287:1809-1815(2000) [PubMed: 10710307] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC58 / Serogroup B.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE002098 Genomic DNA. Translation: AAF40566.1.
PIR	B81238.
RefSeq	NP_273165.1. NC_003112.2.
3D structure databases
ProteinModelPortal	Q9K1K9.
SMR	Q9K1K9. Positions 13-151.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000010226; EBNEIP00000009846; EBNEIG00000010226.
GeneID	902211.
GenomeReviews	Gene locus NMB0107 in contig AE002098_GR.
KEGG	nme:NMB0107.
PATRIC	20355227. VBINeiMen85645_0147.
TIGR	NMB0107.
Phylogenomic databases
GeneTree	EBGT00050000021674.
HOGENOM	HBG305327.
OMA	TVIDHIT.
ProtClustDB	PRK00893.
Enzyme and pathway databases
BioCyc	NMEN122586:NMB_0107-MONOMER.
Family and domain databases
HAMAP	MF_00002. Asp_carb_tr_reg. [Tree]
InterPro	IPR020545. Asp_carbamoyltransf_reg_N. IPR002801. Asp_carbamoylTrfase_reg. IPR020542. Asp_carbamoyltrfase_reg_C. [Graphical view]
Gene3D	G3DSA:2.30.30.20. PyrI. 1 hit. G3DSA:3.30.70.140. PyrI. 1 hit.
KO	K00610.
Pfam	PF01948. PyrI. 1 hit. PF02748. PyrI_C. 1 hit. [Graphical view]
ProDom	PD006194. Asp_carbamoylTrfase_reg. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF54893. Asp_carbamoylTrfase_reg. 1 hit. SSF57825. Asp_transf_reg_C. 1 hit.
TIGRFAMs	TIGR00240. ATCase_reg. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PYRI_NEIMB

Accession

Primary (citable) accession number: Q9K1K9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program