ID   NUOC_NEIMB              Reviewed;         197 AA.
AC   Q9K1C1;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   16-JUN-2009, entry version 46.
DE   RecName: Full=NADH-quinone oxidoreductase subunit C;
DE            EC=1.6.99.5;
DE   AltName: Full=NADH dehydrogenase I subunit C;
DE   AltName: Full=NDH-1 subunit C;
GN   Name=nuoC; OrderedLocusNames=NMB0243;
OS   Neisseria meningitidis serogroup B.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
OC   Neisseriaceae; Neisseria.
OX   NCBI_TaxID=491;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58 / Serogroup B;
RX   MEDLINE=20175755; PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C.,
RA   Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F.,
RA   Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D.,
RA   Hickey E.K., Haft D.H., Salzberg S.L., White O., Fleischmann R.D.,
RA   Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E.,
RA   Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M.,
RA   Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M.,
RA   Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R.,
RA   Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
CC   -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-
CC       sulfur (Fe-S) centers, to quinones in the respiratory chain. The
CC       immediate electron acceptor for the enzyme in this species is
CC       believed to be ubiquinone. Couples the redox reaction to proton
CC       translocation (for every two electrons transferred, four hydrogen
CC       ions are translocated across the cytoplasmic membrane), and thus
CC       conserves the redox energy in a proton gradient (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADH + quinone = NAD(+) + quinol.
CC   -!- SUBUNIT: NDH-1 is composed of 14 different subunits. Subunits
CC       nuoB, C, D, E, F, and G constitute the peripheral sector of the
CC       complex (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane
CC       protein; Cytoplasmic side (By similarity).
CC   -!- SIMILARITY: Belongs to the complex I 30 kDa subunit family.
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DR   EMBL; AE002098; AAF40697.1; -; Genomic_DNA.
DR   PIR; A81222; A81222.
DR   RefSeq; NP_273299.1; -.
DR   GeneID; 902354; -.
DR   GenomeReviews; AE002098_GR; NMB0243.
DR   KEGG; nme:NMB0243; -.
DR   NMPDR; fig|122586.1.peg.233; -.
DR   TIGR; NMB0243; -.
DR   HOGENOM; Q9K1C1; -.
DR   OMA; Q9K1C1; VFAPDDD.
DR   BioCyc; NMEN122586:NMB_0243-MON; -.
DR   BRENDA; 1.6.99.5; 293828.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:HAMAP.
DR   GO; GO:0019684; P:photosynthesis, light reaction; IEA:HAMAP.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   HAMAP; MF_01357; -; 1.
DR   InterPro; IPR010218; NADH_DH_csu.
DR   InterPro; IPR001268; NADH_UbQ_OxRdtase_30kDa_su.
DR   Pfam; PF00329; Complex1_30kDa; 1.
DR   ProDom; PD001581; Complex1_30K; 1.
DR   TIGRFAMs; TIGR01961; NuoC_fam; 1.
DR   PROSITE; PS00542; COMPLEX1_30K; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Complete proteome; Membrane; NAD;
KW   Oxidoreductase; Quinone; Transport; Ubiquinone.
FT   CHAIN         1    197       NADH-quinone oxidoreductase subunit C.
FT                                /FTId=PRO_0000118673.
SQ   SEQUENCE   197 AA;  23007 MW;  983591220B39E2DC CRC64;
     MASIQDLYET VSRVLGNQAG KVISALGEIT VECLPEHYIS VMTALRDHEE LHFELLVDLC
     GVDYSTYKNE AWQGKRFAVV SQLLSVKNNQ RIRVRVWVSD DDFPVVESVV DIYNSADWYE
     REAFDMYGIM FNNHPDLRRI LTDYGFVGHP FRKDFPISGY VEMRYDEEQK RVIYQPVTIE
     PREITPRIVR EENYGGQ
//