Q9K1C1 (NUOC_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH-quinone oxidoreductase subunit C
EC=1.6.99.5

Alternative name(s):
NADH dehydrogenase I subunit C
NDH-1 subunit C

Gene names

Name:	nuoC
Ordered Locus Names:	NMB0243

Organism

Neisseria meningitidis serogroup B

Taxonomic identifier

491 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP MF_01357
Catalytic activity	NADH + quinone = NAD+ + quinol. HAMAP MF_01357
Subunit structure	NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity HAMAP MF_01357.
Sequence similarities	Belongs to the complex I 30 kDa subunit family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	NADH-quinone oxidoreductase subunit C HAMAP MF_01357		PRO_0000118673

Sequences

	Sequence		Length	Mass (Da)
	Q9K1C1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 983591220B39E2DC	FASTA	197	23,007
	10 20 30 40 50 60 MASIQDLYET VSRVLGNQAG KVISALGEIT VECLPEHYIS VMTALRDHEE LHFELLVDLC 70 80 90 100 110 120 GVDYSTYKNE AWQGKRFAVV SQLLSVKNNQ RIRVRVWVSD DDFPVVESVV DIYNSADWYE 130 140 150 160 170 180 REAFDMYGIM FNNHPDLRRI LTDYGFVGHP FRKDFPISGY VEMRYDEEQK RVIYQPVTIE 190 PREITPRIVR EENYGGQ

References

[1]

"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58." Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O. , Fleischmann R.D., Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., Venter J.C. Science 287:1809-1815(2000) [PubMed: 10710307] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC58 / Serogroup B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE002098 Genomic DNA. Translation: AAF40697.1.
PIR	A81222.
RefSeq	NP_273299.1. NC_003112.2.
3D structure databases
ProteinModelPortal	Q9K1C1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000009821; EBNEIP00000009441; EBNEIG00000009821.
GeneID	902354.
GenomeReviews	Gene locus NMB0243 in contig AE002098_GR.
KEGG	nme:NMB0243.
NMPDR	fig|122586.1.peg.233.
PATRIC	20355562. VBINeiMen85645_0305.
TIGR	NMB0243.
Phylogenomic databases
GeneTree	EBGT00050000020693.
HOGENOM	HBG727675.
OMA	RLRVFAP.
ProtClustDB	PRK06074.
Enzyme and pathway databases
BioCyc	NMEN122586:NMB_0243-MONOMER.
Family and domain databases
HAMAP	MF_01357. NDH1_NuoC. [Tree]
InterPro	IPR010218. NADH_DH_suC. IPR001268. NADH_UbQ_OxRdtase_30kDa_su. IPR020396. NADH_UbQ_OxRdtase_CS. [Graphical view]
KO	K00332.
Pfam	PF00329. Complex1_30kDa. 1 hit. [Graphical view]
ProDom	PD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01961. NuoC_fam. 1 hit.
PROSITE	PS00542. COMPLEX1_30K. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOC_NEIMB

Accession

Primary (citable) accession number: Q9K1C1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program