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Q9K1C0 (NUOD_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit D
EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit D
NDH-1 subunit D
Gene names
Name:nuoD
Ordered Locus Names:NMB0244
OrganismNeisseria meningitidis serogroup B
Taxonomic identifier491 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP MF_01358

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP MF_01358

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity HAMAP MF_01358.

Sequence similarities

Belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNAD binding

Inferred from electronic annotation. Source: InterPro

NADH dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: EC

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 418418NADH-quinone oxidoreductase subunit D HAMAP MF_01358
PRO_0000357868

Sequences

Sequence LengthMass (Da)Tools
Q9K1C0 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: C207871651F5CA1D

FASTA41847,710
        10         20         30         40         50         60 
MANKLRNYTI NFGPQHPAAH GVLRMILELD GEQIVRADPH IGLLHRGTEK LAETKTYLQA 

        70         80         90        100        110        120 
LPYMDRLDYV SMMVNEQAYC LAVEKLVGID VPIRAQYIRV MFAEVTRILN HLMGIGSHAF 

       130        140        150        160        170        180 
DIGAMTAILY AFRDREELMD LYEAVSGARM HAAYFRPGGV YRDLPDFMPK YEGSKFRNAK 

       190        200        210        220        230        240 
VLKQLNESRE GTMLDFIDAF CERFPKNIDT LETLLTDNRI WKQRTVGIGV VSPERAMQKG 

       250        260        270        280        290        300 
FTGVMLRGSG VEWDVRKTQP YEVYDKMDFD IPVGVNGDCY DRYLCRMEEM RQSVRIIKQC 

       310        320        330        340        350        360 
SEWLRVNPGP VITTNHKFAP PKRTEMKTGM EDLIHHFKLF TEGMHVPEGE TYTAVEHPKG 

       370        380        390        400        410 
EFGVYIISDG ANKPYRLKIR APGFAHLQGM DEMAKGHMLA DVVAIIGTQD IVFGEVDR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE002098 Genomic DNA. Translation: AAF40698.1.
PIRB81222.
RefSeqNP_273300.1. NC_003112.2.

3D structure databases

HSSPHSSP built from PDB template 2FUG based on UniProtKB Q56220.
ProteinModelPortalQ9K1C0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBNEIT00000009347; EBNEIP00000008967; EBNEIG00000009347.
GeneID902355.
GenomeReviewsGene locus NMB0244 in contig AE002098_GR.
KEGGnme:NMB0244.
NMPDRfig|122586.1.peg.234.
PATRIC20355564. VBINeiMen85645_0306.
TIGRNMB0244.

Phylogenomic databases

GeneTreeEBGT00050000021494.
HOGENOMHBG459705.
OMAMADVITI.
ProtClustDBPRK06075.

Enzyme and pathway databases

BioCycNMEN122586:NMB_0244-MONOMER.

Family and domain databases

HAMAPMF_01358. NDH1_NuoD.
[Tree]
InterProIPR010219. NADH_DH_1_suD.
IPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
[Graphical view]
KOK00333.
PfamPF00346. Complex1_49kDa. 2 hits.
[Graphical view]
TIGRFAMsTIGR01962. NuoD. 1 hit.
PROSITEPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOD_NEIMB
AccessionPrimary (citable) accession number: Q9K1C0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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