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Q9K1B0 (NUOL_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit L
EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit L
NDH-1 subunit L
Gene names
Name:nuoL
Ordered Locus Names:NMB0257
OrganismNeisseria meningitidis serogroup B
Taxonomic identifier491 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length674 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.

Catalytic activity

NADH + quinone = NAD+ + quinol.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the complex I subunit 5 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processATP synthesis coupled electron transport

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: InterPro

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 674674NADH-quinone oxidoreductase subunit L
PRO_0000118220

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane36 – 5621Helical; Potential
Transmembrane67 – 8721Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane140 – 16021Helical; Potential
Transmembrane180 – 20021Helical; Potential
Transmembrane219 – 23921Helical; Potential
Transmembrane259 – 27921Helical; Potential
Transmembrane293 – 31321Helical; Potential
Transmembrane348 – 36821Helical; Potential
Transmembrane385 – 40521Helical; Potential
Transmembrane425 – 44521Helical; Potential
Transmembrane488 – 50821Helical; Potential
Transmembrane549 – 56921Helical; Potential
Transmembrane653 – 67321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9K1B0 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: C915DA24F0FDE5A3

FASTA67474,229
        10         20         30         40         50         60 
MNDMTLYLII ALVPLAGSLI AGLFGNKIGR AGAHTVTILG VAVSAVLSAY VLWGFIDGSR 

        70         80         90        100        110        120 
AKFDENVYTW LTMGGLDFSV GFLVDTMTAM MMVVVTGVSL MVHIYTIGYM HDEKVGYQRF 

       130        140        150        160        170        180 
FSYISLFTFS MLMLIMSNNF IQLFFGWEAV GLVSYLLIGF YFKRPSATFA NLKAFLINRV 

       190        200        210        220        230        240 
GDFGFLLGIG LVLAYFGGSL RYQDVFAYLP NVQNATIQLF PGVEWSLITV TCLLLFVGAM 

       250        260        270        280        290        300 
GKSAQFPLHV WLPDSMEGPT PISALIHAAT MVTAGLFMVS RMSPIYEMSS TALSVIMVIG 

       310        320        330        340        350        360 
AITALFMGFL GVIQNDIKRV VAYSTLSQLG YMTVALGASA YSVAMFHVMT HAFFKALLFL 

       370        380        390        400        410        420 
AAGSAIIGMH HDQDMRHMGN LKKYMPVTWL TMLIGNLSLI GTPFFSGFYS KDSIIEAAKY 

       430        440        450        460        470        480 
STLPGSGFAY FAVLASVFVT AFYAFRQYFM VFHGEEKWRS LPEHHSDGHG EEHHGLGKND 

       490        500        510        520        530        540 
NPHESPLVVT LPLILLAVPS VIIGYIAIEP MLYGDFFKDV IFVNADAHPT IHIMKEEFHG 

       550        560        570        580        590        600 
ALAMVSHSLH SPVLYLAIAG VLSAWLLYVK LPHLPAKIAQ TFRPIYVLFE NKYYLDALYF 

       610        620        630        640        650        660 
NVFAKGTRAL GTFFWKVGDT AIIDNGIVNG SAKLVGAIAA QVRKAQTGFI YTYAAAMVFG 

       670 
VLVLLGMTFW GLFR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE002098 Genomic DNA. Translation: AAF40711.1.
PIRD81220.
RefSeqNP_273313.1. NC_003112.2.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBNEIT00000009598; EBNEIP00000009218; EBNEIG00000009598.
GeneID902368.
GenomeReviewsGene locus NMB0257 in contig AE002098_GR.
KEGGnme:NMB0257.
NMPDRfig|122586.1.peg.247.
PATRIC20355592. VBINeiMen85645_0320.
TIGRNMB0257.

Phylogenomic databases

GeneTreeEBGT00050000020201.
HOGENOMHBG643593.
OMAIGYMADD.
ProtClustDBPRK06590.

Enzyme and pathway databases

BioCycNMEN122586:NMB_0257-MONOMER.

Family and domain databases

InterProIPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR001516. NADH_UbQ_OxRdtase_chain5/L_N.
IPR002128. NADH_UbQ_OxRdtase_chlpt_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR018393. NADHpl_OxRdtase_5_subgr.
[Graphical view]
KOK00341.
PfamPF00361. Oxidored_q1. 1 hit.
PF01010. Oxidored_q1_C. 1 hit.
PF00662. Oxidored_q1_N. 1 hit.
[Graphical view]
PRINTSPR01435. NPOXDRDTASE5.
TIGRFAMsTIGR01974. NDH_I_L. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNUOL_NEIMB
AccessionPrimary (citable) accession number: Q9K1B0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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