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Q9K1A8 (Q9K1A8_NEIMB) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit N HAMAP MF_00445
EC=1.6.99.5 HAMAP MF_00445
Alternative name(s):
NADH dehydrogenase I subunit N HAMAP MF_00445
NDH-1 subunit N HAMAP MF_00445
Gene names
Name:nuoN HAMAP MF_00445
Ordered Locus Names:NMB0259
OrganismNeisseria meningitidis serogroup B
Taxonomic identifier491 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP MF_00445

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP MF_00445

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity. HAMAP MF_00445

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00445.

Sequence similarities

Belongs to the complex I subunit 2 family. HAMAP MF_00445

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Transmembrane11 – 3121Helical; By similarity HAMAP MF_00445
Transmembrane38 – 5821Helical; By similarity HAMAP MF_00445
Transmembrane74 – 9421Helical; By similarity HAMAP MF_00445
Transmembrane103 – 12321Helical; By similarity HAMAP MF_00445
Transmembrane128 – 14821Helical; By similarity HAMAP MF_00445
Transmembrane163 – 18321Helical; By similarity HAMAP MF_00445
Transmembrane210 – 23021Helical; By similarity HAMAP MF_00445
Transmembrane241 – 26121Helical; By similarity HAMAP MF_00445
Transmembrane272 – 29221Helical; By similarity HAMAP MF_00445
Transmembrane311 – 33121Helical; By similarity HAMAP MF_00445
Transmembrane332 – 35221Helical; By similarity HAMAP MF_00445
Transmembrane368 – 38821Helical; By similarity HAMAP MF_00445
Transmembrane404 – 42421Helical; By similarity HAMAP MF_00445
Transmembrane449 – 46921Helical; By similarity HAMAP MF_00445

Sequences

Sequence LengthMass (Da)Tools
Q9K1A8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: D05A272BAB24EB15

FASTA48052,126
        10         20         30         40         50         60 
MNWSDLNLMP AMPEIVLLSL LVLLLLADLW VSDDKRPWTH YGALATVAVT AVVQLAVWEQ 

        70         80         90        100        110        120 
GSTSSFNGMY IADGMSRLAK MVLYALTFAL FVYAKPYNQV RGIFKGEFYT LSLFALLGMS 

       130        140        150        160        170        180 
VMVSAGHFLT AYIGLELLSL ALYALIALRR DSGFAAEAAL KYFVLGALAS GLLLYGISMV 

       190        200        210        220        230        240 
YGATGSLEFA GVLASSFNEE ANEWLLKLGL VFIVVAVAFK LGAVPFHMWV PDVYHGAPTS 

       250        260        270        280        290        300 
VTALVGTAPK IAAVVFTFRI LVTGLGTVHH DWSLMFALLA AASLLVGNLA AIMQTNIKRM 

       310        320        330        340        350        360 
FAYSTVSHMG FILLAFMAGA VGFAAGLYYA ITYALMAAAG FGVLMVLSDG DNECENISDL 

       370        380        390        400        410        420 
AGLNQHRVWL AFLMLLVMFS MAGIPPLMGF YAKFGVIMAL LKQGHVWLSV FAVIMSLIGA 

       430        440        450        460        470        480 
FYYLRVVKVI YFDVPDHDQP VGSNYAAKFV LTVNAFLLLL WGIMPQTVID WCAKALENTL

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE002098 Genomic DNA. Translation: AAF40713.1.
PIRF81220.
RefSeqNP_273315.1. NC_003112.2.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBNEIT00000010499; EBNEIP00000010119; EBNEIG00000010499.
GeneID902370.
GenomeReviewsGene locus NMB0259 in contig AE002098_GR.
KEGGnme:NMB0259.
NMPDRfig|122586.1.peg.249.
PATRIC20355596. VBINeiMen85645_0322.
TIGRNMB0259.

Phylogenomic databases

GeneTreeEBGT00050000020201.
HOGENOMHBG747830.
OMATKSANIG.
ProtClustDBPRK05777.

Family and domain databases

HAMAPMF_00445. NDH1_NuoN_1.
[Tree]
InterProIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
KOK00343.
PfamPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsTIGR01770. NDH_I_N. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ9K1A8_NEIMB
AccessionPrimary (citable) accession number: Q9K1A8
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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