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Protein
Submitted name:

Thiol:disulfide interchange protein DsbA

Gene

dsbA-1

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciNMEN122586:GHGG-293-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Thiol:disulfide interchange protein DsbAImported
Gene namesi
Name:dsbA-1Imported
Ordered Locus Names:NMB0278Imported
OrganismiNeisseria meningitidis serogroup B (strain MC58)Imported
Taxonomic identifieri122586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 232215Sequence analysisPRO_5004332314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi75 ↔ 78Combined sources
Disulfide bondi75 ↔ 78Redox-activeUniRule annotation

Proteomic databases

PaxDbiQ9K189.

Interactioni

Protein-protein interaction databases

STRINGi122586.NMB0278.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A3TX-ray2.10A/B/C/D/E/F42-232[»]
3DVWX-ray1.50A41-232[»]
3HZ8X-ray1.45A41-232[»]
ProteinModelPortaliQ9K189.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9K189.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 229204ThioredoxinInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiCOG0526. LUCA.
HOGENOMiHOG000265318.
KOiK03673.
OMAiNAIHKQK.
OrthoDBiEOG68Q0Q6.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR023205. DsbA/DsbL.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF13462. Thioredoxin_4. 1 hit.
[Graphical view]
PIRSFiPIRSF001488. Tdi_protein. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9K189-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSRHLALGV AALFALAACD SKVQTSVPAD SAPAASAAAA PAGLVEGQNY
60 70 80 90 100
TVLANPIPQQ QAGKVEVLEF FGYFCPHCAH LEPVLSKHAK SFKDDMYLRT
110 120 130 140 150
EHVVWQKEML TLARLAAAVD MAAADSKDVA NSHIFDAMVN QKIKLQNPEV
160 170 180 190 200
LKKWLGEQTA FDGKKVLAAY ESPESQARAD KMQELTETFQ IDGTPTVIVG
210 220 230
GKYKVEFADW ESGMNTIDLL ADKVREEQKA AQ
Length:232
Mass (Da):25,250
Last modified:October 1, 2000 - v1
Checksum:i186EF798E448A2B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002098 Genomic DNA. Translation: AAF40732.1.
PIRiC81217.
RefSeqiNP_273334.1. NC_003112.2.
WP_002224844.1. NC_003112.2.

Genome annotation databases

EnsemblBacteriaiAAF40732; AAF40732; NMB0278.
GeneIDi902389.
KEGGinme:NMB0278.
PATRICi20355646. VBINeiMen85645_0347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002098 Genomic DNA. Translation: AAF40732.1.
PIRiC81217.
RefSeqiNP_273334.1. NC_003112.2.
WP_002224844.1. NC_003112.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A3TX-ray2.10A/B/C/D/E/F42-232[»]
3DVWX-ray1.50A41-232[»]
3HZ8X-ray1.45A41-232[»]
ProteinModelPortaliQ9K189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi122586.NMB0278.

Proteomic databases

PaxDbiQ9K189.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF40732; AAF40732; NMB0278.
GeneIDi902389.
KEGGinme:NMB0278.
PATRICi20355646. VBINeiMen85645_0347.

Phylogenomic databases

eggNOGiCOG0526. LUCA.
HOGENOMiHOG000265318.
KOiK03673.
OMAiNAIHKQK.
OrthoDBiEOG68Q0Q6.

Enzyme and pathway databases

BioCyciNMEN122586:GHGG-293-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9K189.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR023205. DsbA/DsbL.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF13462. Thioredoxin_4. 1 hit.
[Graphical view]
PIRSFiPIRSF001488. Tdi_protein. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC58Imported.
  2. "Biochemical and structural study of the homologues of the thiol-disulfide oxidoreductase DsbA in Neisseria meningitidis."
    Lafaye C., Iwema T., Carpentier P., Jullian-Binard C., Kroll J.S., Collet J.F., Serre L.
    J. Mol. Biol. 392:952-966(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 41-232, DISULFIDE BONDS.
  3. Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 42-232, DISULFIDE BONDS.

Entry informationi

Entry nameiQ9K189_NEIMB
AccessioniPrimary (citable) accession number: Q9K189
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.