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Q9K168 (DYR_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydrofolate reductase

EC=1.5.1.3
Gene names
Name:folA
Ordered Locus Names:NMB0308
OrganismNeisseria meningitidis serogroup B (strain MC58) [Reference proteome] [HAMAP]
Taxonomic identifier122586 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length162 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis By similarity.

Catalytic activity

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.

Sequence similarities

Belongs to the dihydrofolate reductase family.

Contains 1 DHFR (dihydrofolate reductase) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 162162Dihydrofolate reductase
PRO_0000186403

Regions

Domain3 – 161159DHFR
Nucleotide binding8 – 92NADP By similarity
Nucleotide binding16 – 216NADP By similarity
Nucleotide binding45 – 484NADP By similarity
Nucleotide binding65 – 684NADP By similarity
Nucleotide binding98 – 1036NADP By similarity
Region7 – 93Substrate binding By similarity

Sites

Binding site291Substrate By similarity
Binding site601Substrate By similarity
Binding site1171Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9K168 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: B5EBB53CEABB8F62

FASTA16217,752
        10         20         30         40         50         60 
MLKITLIAAC AENLCIGAGN AMPWHIPEDF AFFKAYTLGK PVIMGRKTWE SLPVKPLPGR 

        70         80         90        100        110        120 
RNIVISRQAD YCAAGAETAA SLEAALALCA GAEEAVIMGG AQIYGQAMPL ATDLRITEVD 

       130        140        150        160 
LSVEGDAFFP AIDRTHWKEA ERTERRVSSK GTRYAFVHYL RY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE002098 Genomic DNA. Translation: AAF40754.1.
PIRG81214.
RefSeqNP_273358.1. NC_003112.2.

3D structure databases

ProteinModelPortalQ9K168.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING122586.NMB0308.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF40754; AAF40754; NMB0308.
GeneID902424.
KEGGnme:NMB0308.
PATRIC20355727. VBINeiMen85645_0383.

Phylogenomic databases

eggNOGCOG0262.
HOGENOMHOG000040234.
KOK00287.
OMACITHVEA.
OrthoDBEOG6KT2V2.

Enzyme and pathway databases

BioCycNMEN122586:GHGG-328-MONOMER.
UniPathwayUPA00077; UER00158.

Family and domain databases

Gene3D3.40.430.10. 1 hit.
InterProIPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]
PfamPF00186. DHFR_1. 1 hit.
[Graphical view]
PIRSFPIRSF000194. DHFR. 1 hit.
PRINTSPR00070. DHFR.
SUPFAMSSF53597. SSF53597. 1 hit.
PROSITEPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDYR_NEIMB
AccessionPrimary (citable) accession number: Q9K168
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways