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Protein

Glucose-6-phosphate isomerase 2

Gene

pgi2

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase 2 (pgi2), Glucose-6-phosphate isomerase 1 (pgi1)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei351Proton donorBy similarity1
Active sitei382By similarity1
Active sitei508By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciNMEN122586:G1G1B-330-MONOMER
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase 2 (EC:5.3.1.9)
Short name:
GPI 2
Alternative name(s):
Phosphoglucose isomerase 2
Short name:
PGI 2
Phosphohexose isomerase 2
Short name:
PHI 2
Gene namesi
Name:pgi2
Ordered Locus Names:NMB0334
OrganismiNeisseria meningitidis serogroup B (strain MC58)
Taxonomic identifieri122586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001806941 – 547Glucose-6-phosphate isomerase 2Add BLAST547

Proteomic databases

PaxDbiQ9K153

Interactioni

Protein-protein interaction databases

STRINGi122586.NMB0334

Structurei

3D structure databases

ProteinModelPortaliQ9K153
SMRiQ9K153
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiENOG4107QP8 Bacteria
COG0166 LUCA
HOGENOMiHOG000261370
KOiK01810
OMAiSFIIPDD
OrthoDBiPOG091H0EIM

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9K153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAFTRAWYA LERHYQDTRH VLLRDRFACE PDRFERMHER LDGMLFDYSK
60 70 80 90 100
NRLGEDTLQL LCNLADAADL EGKMRALRTG AKVNGSEGRA ALHTALRLPD
110 120 130 140 150
GADAVYVDGR DVLPEIRREL NRALKFAHSL DDGSYQGITG KRITDFVHIG
160 170 180 190 200
IGGSDLGPAM CVQALEPFRR HITVHFAANA DPACLDAVLC RLNPETTVFC
210 220 230 240 250
VASKSFKTPE TLLNAQAVKA WYRGAGFSES ETACHFCAVS ADTAAAAAFG
260 270 280 290 300
IAAERVFAMY DWVGGRYSVW SPVGLPVMVA VGGARFRELL AGAHAMDRHF
310 320 330 340 350
FSTPTRHNIP VLMALIAVWY NNFQHADGQT AVPYSHNLRL LPAWLNQLDM
360 370 380 390 400
ESLGKSRASD GSPAVCKTGG IVFGGEGVNC QHAYFQLLHQ GTRLIPCDFI
410 420 430 440 450
VPMTAQGRED GRSRFTVANA FAQAEALMKG KTLDEARAEL ADLPEAERER
460 470 480 490 500
LAPHKEFPGN RPSNSILIDR LTPYNLGMLM AAYEHKTFVQ GAIWNVNPFD
510 520 530 540
QWGVEYGKQL AKTIIGELEG GTSVHDASTE GLMAFYRECR LKGGGAA
Length:547
Mass (Da):60,199
Last modified:October 1, 2000 - v1
Checksum:i54B0CC7FB74BA028
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002098 Genomic DNA Translation: AAF40777.1
PIRiA81211
RefSeqiNP_273383.1, NC_003112.2
WP_002224874.1, NC_003112.2

Genome annotation databases

EnsemblBacteriaiAAF40777; AAF40777; NMB0334
GeneIDi902449
KEGGinme:NMB0334
PATRICifig|122586.8.peg.422

Similar proteinsi

Entry informationi

Entry nameiG6PI2_NEIMB
AccessioniPrimary (citable) accession number: Q9K153
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: October 1, 2000
Last modified: February 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health