Reviewed, UniProtKB/Swiss-Prot Q9K153 (G6PI2_NEIMB)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase 2
      Short name=GPI 2
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase 2
      Short name=PGI 2
    Phosphohexose isomerase 2
      Short name=PHI 2

Gene names

Name:	pgi2
Ordered Locus Names:	NMB0334

Organism

Neisseria meningitidis serogroup B [Complete proteome] [HAMAP]

Taxonomic identifier

491 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	547 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 547	547	Glucose-6-phosphate isomerase 2 HAMAP MF_00473		PRO_0000180694
Sites
	Active site	351	1	Proton donor By similarity
	Active site	382	1	By similarity
	Active site	508	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9K153-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 54B0CC7FB74BA028	FASTA	547	60,199
	10 20 30 40 50 60 MNAFTRAWYA LERHYQDTRH VLLRDRFACE PDRFERMHER LDGMLFDYSK NRLGEDTLQL 70 80 90 100 110 120 LCNLADAADL EGKMRALRTG AKVNGSEGRA ALHTALRLPD GADAVYVDGR DVLPEIRREL 130 140 150 160 170 180 NRALKFAHSL DDGSYQGITG KRITDFVHIG IGGSDLGPAM CVQALEPFRR HITVHFAANA 190 200 210 220 230 240 DPACLDAVLC RLNPETTVFC VASKSFKTPE TLLNAQAVKA WYRGAGFSES ETACHFCAVS 250 260 270 280 290 300 ADTAAAAAFG IAAERVFAMY DWVGGRYSVW SPVGLPVMVA VGGARFRELL AGAHAMDRHF 310 320 330 340 350 360 FSTPTRHNIP VLMALIAVWY NNFQHADGQT AVPYSHNLRL LPAWLNQLDM ESLGKSRASD 370 380 390 400 410 420 GSPAVCKTGG IVFGGEGVNC QHAYFQLLHQ GTRLIPCDFI VPMTAQGRED GRSRFTVANA 430 440 450 460 470 480 FAQAEALMKG KTLDEARAEL ADLPEAERER LAPHKEFPGN RPSNSILIDR LTPYNLGMLM 490 500 510 520 530 540 AAYEHKTFVQ GAIWNVNPFD QWGVEYGKQL AKTIIGELEG GTSVHDASTE GLMAFYRECR LKGGGAA

References

[1]

"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58." Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O. , Fleischmann R.D., Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., Venter J.C. Science 287:1809-1815(2000) [PubMed: 10710307] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC58 / Serogroup B.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE002098 Genomic DNA. Translation: AAF40777.1.
PIR	A81211.
RefSeq	NP_273383.1.
3D structure databases
HSSP	HSSP built from PDB template 1JIQ based on UniProtKB P06744.
ModBase	Search...
Genome annotation databases
GeneID	902449.
GenomeReviews	Gene locus NMB0334 in contig AE002098_GR.
KEGG	nme:NMB0334.
NMPDR	fig|122586.1.peg.317.
TIGR	NMB0334.
Phylogenomic databases
HOGENOM	Q9K153.
OMA	HDASTEG.
Enzyme and pathway databases
BioCyc	NMEN122586:NMB_0334-MON.
BRENDA	5.3.1.9. 293828.
Family and domain databases
HAMAP	MF_00473. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI2_NEIMB

Accession

Primary (citable) accession number: Q9K153

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	October 1, 2000
Last modified:	November 3, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)