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Q9K151

- FABI_NEIMB

UniProt

Q9K151 - FABI_NEIMB

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Protein

Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

Gene
fabI, NMB0336
Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism By similarity.

Catalytic activityi

An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131NAD; via carbonyl oxygen By similarity
Binding sitei92 – 921NAD; via carbonyl oxygen By similarity
Binding sitei95 – 951Substrate; via amide nitrogen and carbonyl oxygen By similarity
Active sitei147 – 1471Proton acceptor By similarity
Active sitei157 – 1571Proton acceptor By similarity
Binding sitei164 – 1641NAD By similarity
Sitei206 – 2061Involved in acyl-ACP binding By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 202NAD By similarity
Nucleotide bindingi64 – 652NAD By similarity
Nucleotide bindingi193 – 1975NAD By similarity

GO - Molecular functioni

  1. enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: UniProtKB

GO - Biological processi

  1. fatty acid elongation Source: UniProtKB
  2. protein homotetramerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciNMEN122586:GHGG-357-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (EC:1.3.1.9)
Short name:
ENR
Alternative name(s):
NADH-dependent enoyl-ACP reductase
Gene namesi
Name:fabI
Ordered Locus Names:NMB0336
OrganismiNeisseria meningitidis serogroup B (strain MC58)
Taxonomic identifieri122586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000000425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Enoyl-[acyl-carrier-protein] reductase [NADH] FabIPRO_0000320269Add
BLAST

Proteomic databases

PRIDEiQ9K151.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi122586.NMB0336.

Structurei

3D structure databases

ProteinModelPortaliQ9K151.
SMRiQ9K151. Positions 2-258.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0623.
KOiK00208.
OMAiTGEIHHV.
OrthoDBiEOG6HF644.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PIRSFiPIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSiPR00081. GDHRDH.

Sequencei

Sequence statusi: Complete.

Q9K151-1 [UniParc]FASTAAdd to Basket

« Hide

MGFLQGKKIL ITGMISERSI AYGIAKACRE QGAELAFTYV VDKLEERVRK    50
MAAELDSELV FRCDVASDDE INQVFADLGK HWDGLDGLVH SIGFAPKEAL 100
SGDFLDSISR EAFNTAHEIS AYSLPALAKA ARPMMRGRNS AIVALSYLGA 150
VRAIPNYNVM GMAKASLEAG IRFTAACLGK EGIRCNGISA GPIKTLAASG 200
IADFGKLLGH VAAHNPLRRN VTIEEVGNTA AFLLSDLSSG ITGEITYVDG 250
GYSINALSTE G 261
Length:261
Mass (Da):27,691
Last modified:October 1, 2000 - v1
Checksum:iAF2D0C70F550253D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002098 Genomic DNA. Translation: AAF40779.1.
PIRiC81211.
RefSeqiNP_273385.1. NC_003112.2.

Genome annotation databases

EnsemblBacteriaiAAF40779; AAF40779; NMB0336.
GeneIDi902451.
KEGGinme:NMB0336.
PATRICi20355813. VBINeiMen85645_0425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002098 Genomic DNA. Translation: AAF40779.1 .
PIRi C81211.
RefSeqi NP_273385.1. NC_003112.2.

3D structure databases

ProteinModelPortali Q9K151.
SMRi Q9K151. Positions 2-258.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 122586.NMB0336.

Proteomic databases

PRIDEi Q9K151.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF40779 ; AAF40779 ; NMB0336 .
GeneIDi 902451.
KEGGi nme:NMB0336.
PATRICi 20355813. VBINeiMen85645_0425.

Phylogenomic databases

eggNOGi COG0623.
KOi K00208.
OMAi TGEIHHV.
OrthoDBi EOG6HF644.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci NMEN122586:GHGG-357-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PIRSFi PIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSi PR00081. GDHRDH.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC58.
  2. "Proteomic analysis of a meningococcal outer membrane vesicle vaccine prepared from the group B strain NZ98/254."
    Vipond C., Suker J., Jones C., Tang C., Feavers I.M., Wheeler J.X.
    Proteomics 6:3400-3413(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: NZ98/254 / Serogroup B.

Entry informationi

Entry nameiFABI_NEIMB
AccessioniPrimary (citable) accession number: Q9K151
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Present in outer membrane vesicle formulations which are used as vaccines in human.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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