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Q9K0Y6 (MRAY_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:NMB0418
OrganismNeisseria meningitidis serogroup B
Taxonomic identifier491 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_0000108858

Regions

Transmembrane24 – 4421Helical; Potential
Transmembrane69 – 8921Helical; Potential
Transmembrane92 – 11221Helical; Potential
Transmembrane133 – 15321Helical; Potential
Transmembrane158 – 17821Helical; Potential
Transmembrane199 – 21921Helical; Potential
Transmembrane239 – 25921Helical; Potential
Transmembrane263 – 28321Helical; Potential
Transmembrane288 – 30821Helical; Potential
Transmembrane337 – 35721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9K0Y6 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: D07D16876DF5FA22

FASTA36039,328
        10         20         30         40         50         60 
MFLWLAHFSN WLTGLNIFQY TTFRAVMAAL TALAFSLMFG PWTIRRLTAL KCGQAVRTDG 

        70         80         90        100        110        120 
PQTHLVKNGT PTMGGSLILT AITVSTLLWG NWANPYIWIL LGVLLATGAL GFYDDWRKVV 

       130        140        150        160        170        180 
YKDPNGVSAK FKMVWQSSVA IIASLALFYL AANSANNILI VPFFKQIALP LGVVGFLVLS 

       190        200        210        220        230        240 
YLTIVGTSNA VNLTDGLDGL ATFPVVLVAA GLAIFAYASG HSQFAQYLQL PYVAGANEVV 

       250        260        270        280        290        300 
IFCTAMCGAC LGFLWFNAYP AQVFMGDVGA LALGAALGTV AVIVRQEFVL VIMGGLFVVE 

       310        320        330        340        350        360 
AVSVMLQVGW YKKTKKRIFL MAPIHHHYEQ KGWKETQVVV RFWIITIVLV LIGLSTLKIR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE002098 Genomic DNA. Translation: AAF40856.1.
PIRE81200.
RefSeqNP_273466.1. NC_003112.2.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBNEIT00000008979; EBNEIP00000008599; EBNEIG00000008979.
GeneID902534.
GenomeReviewsGene locus NMB0418 in contig AE002098_GR.
KEGGnme:NMB0418.
PATRIC20356030. VBINeiMen85645_0530.
TIGRNMB0418.

Phylogenomic databases

GeneTreeEBGT00050000021476.
HOGENOMHBG708263.
OMARFWIISM.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycNMEN122586:NMB_0418-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_NEIMB
AccessionPrimary (citable) accession number: Q9K0Y6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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