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Q9K0V3 (AMIC_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-acetylmuramoyl-L-alanine amidase AmiC

EC=3.5.1.28
Gene names
Name:amiC
Ordered Locus Names:NMB0456
OrganismNeisseria meningitidis serogroup B (strain MC58) [Reference proteome] [HAMAP]
Taxonomic identifier122586 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cell-wall hydrolase involved in septum cleavage during cell division By similarity.

Catalytic activity

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Subcellular location

Periplasm By similarity.

Miscellaneous

Present in outer membrane vesicle formulations which are used as vaccines in human.

Sequence similarities

Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family.

Ontologies

Keywords
   Biological processCell wall biogenesis/degradation
   Cellular componentPeriplasm
   DomainSignal
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpeptidoglycan catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentperiplasmic space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionN-acetylmuramoyl-L-alanine amidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 416390N-acetylmuramoyl-L-alanine amidase AmiC
PRO_0000320265

Sequences

Sequence LengthMass (Da)Tools
Q9K0V3 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 5E89E0A60DE8AD21

FASTA41645,190
        10         20         30         40         50         60 
MIKLTRRQII RRTAGTLFAL SPIASAVAKT VRAPQFTAAR IWPSHTYTRL TLESTAALKY 

        70         80         90        100        110        120 
QHFTLDNPGR LVVDIQNANI NTVLHGLSQK VMADDPFIRS IRAGQNTPTT VRLVIDLKQP 

       130        140        150        160        170        180 
THAQVFALPP VGGFKNRLVV DLYPHGMDAD DPMMALLNGS LNKTLRGSPE ADLAQNTTPQ 

       190        200        210        220        230        240 
PGRGRNGRRP VIMLDPGHGG EDPGAISPGG LQEKHVVLSI ARETKNQLEA LGYNVFMTRN 

       250        260        270        280        290        300 
EDVFIPLGVR VAKGRARRAD VFVSIHADAF TSPSARGTGV YMLNTKGATS SAAKFLEQTQ 

       310        320        330        340        350        360 
NNADAVGGVP TSGNRNVDTA LLDMTQTATL RDSRKLGKLV LEELGRLNHL HKGRVDEANF 

       370        380        390        400        410 
AVLRAPDMPS ILVETAFLSN PAEEKLLGSE SFRRQCAQSI ASGVQRYINT SVLKRG 

« Hide

References

[1]"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58."
Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O. expand/collapse author list , Fleischmann R.D., Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., Venter J.C.
Science 287:1809-1815(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MC58.
[2]"Characterization of the protein content of a meningococcal outer membrane vesicle vaccine by polyacrylamide gel electrophoresis and mass spectrometry."
Vipond C., Wheeler J.X., Jones C., Feavers I.M., Suker J.
Hum. Vaccin. 1:80-84(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[3]"Proteomic analysis of a meningococcal outer membrane vesicle vaccine prepared from the group B strain NZ98/254."
Vipond C., Suker J., Jones C., Tang C., Feavers I.M., Wheeler J.X.
Proteomics 6:3400-3413(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: NZ98/254 / Serogroup B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE002098 Genomic DNA. Translation: AAF40893.1.
PIRB81198.
RefSeqNP_273503.1. NC_003112.2.

3D structure databases

ProteinModelPortalQ9K0V3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING122586.NMB0456.

Protocols and materials databases

DNASU902572.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF40893; AAF40893; NMB0456.
GeneID902572.
KEGGnme:NMB0456.
PATRIC20356126. VBINeiMen85645_0579.

Phylogenomic databases

eggNOGCOG0860.
HOGENOMHOG000263827.
KOK01448.
OMAWMANKEN.
OrthoDBEOG6CP3X3.

Enzyme and pathway databases

BioCycNMEN122586:GHGG-480-MONOMER.

Family and domain databases

Gene3D3.40.630.40. 2 hits.
InterProIPR021731. AMIN_dom.
IPR002508. CW_Hdrlase/autolysin_cat.
[Graphical view]
PfamPF01520. Amidase_3. 1 hit.
PF11741. AMIN. 1 hit.
[Graphical view]
SMARTSM00646. Ami_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAMIC_NEIMB
AccessionPrimary (citable) accession number: Q9K0V3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families