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Q9K0V3

- AMIC_NEIMB

UniProt

Q9K0V3 - AMIC_NEIMB

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Protein

N-acetylmuramoyl-L-alanine amidase AmiC

Gene

amiC

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Cell-wall hydrolase involved in septum cleavage during cell division.By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciNMEN122586:GHGG-480-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase AmiC (EC:3.5.1.28)
Gene namesi
Name:amiC
Ordered Locus Names:NMB0456
OrganismiNeisseria meningitidis serogroup B (strain MC58)
Taxonomic identifieri122586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000000425: Chromosome

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 416390N-acetylmuramoyl-L-alanine amidase AmiCPRO_0000320265Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi122586.NMB0456.

Structurei

3D structure databases

ProteinModelPortaliQ9K0V3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0860.
HOGENOMiHOG000263827.
KOiK01448.
OMAiWMANKEN.
OrthoDBiEOG6CP3X3.

Family and domain databases

Gene3Di3.40.630.40. 2 hits.
InterProiIPR021731. AMIN_dom.
IPR002508. CW_Hdrlase/autolysin_cat.
[Graphical view]
PfamiPF01520. Amidase_3. 1 hit.
PF11741. AMIN. 1 hit.
[Graphical view]
SMARTiSM00646. Ami_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9K0V3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKLTRRQII RRTAGTLFAL SPIASAVAKT VRAPQFTAAR IWPSHTYTRL
60 70 80 90 100
TLESTAALKY QHFTLDNPGR LVVDIQNANI NTVLHGLSQK VMADDPFIRS
110 120 130 140 150
IRAGQNTPTT VRLVIDLKQP THAQVFALPP VGGFKNRLVV DLYPHGMDAD
160 170 180 190 200
DPMMALLNGS LNKTLRGSPE ADLAQNTTPQ PGRGRNGRRP VIMLDPGHGG
210 220 230 240 250
EDPGAISPGG LQEKHVVLSI ARETKNQLEA LGYNVFMTRN EDVFIPLGVR
260 270 280 290 300
VAKGRARRAD VFVSIHADAF TSPSARGTGV YMLNTKGATS SAAKFLEQTQ
310 320 330 340 350
NNADAVGGVP TSGNRNVDTA LLDMTQTATL RDSRKLGKLV LEELGRLNHL
360 370 380 390 400
HKGRVDEANF AVLRAPDMPS ILVETAFLSN PAEEKLLGSE SFRRQCAQSI
410
ASGVQRYINT SVLKRG
Length:416
Mass (Da):45,190
Last modified:October 1, 2000 - v1
Checksum:i5E89E0A60DE8AD21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002098 Genomic DNA. Translation: AAF40893.1.
PIRiB81198.
RefSeqiNP_273503.1. NC_003112.2.

Genome annotation databases

EnsemblBacteriaiAAF40893; AAF40893; NMB0456.
GeneIDi902572.
KEGGinme:NMB0456.
PATRICi20356126. VBINeiMen85645_0579.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002098 Genomic DNA. Translation: AAF40893.1 .
PIRi B81198.
RefSeqi NP_273503.1. NC_003112.2.

3D structure databases

ProteinModelPortali Q9K0V3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 122586.NMB0456.

Protocols and materials databases

DNASUi 902572.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF40893 ; AAF40893 ; NMB0456 .
GeneIDi 902572.
KEGGi nme:NMB0456.
PATRICi 20356126. VBINeiMen85645_0579.

Phylogenomic databases

eggNOGi COG0860.
HOGENOMi HOG000263827.
KOi K01448.
OMAi WMANKEN.
OrthoDBi EOG6CP3X3.

Enzyme and pathway databases

BioCyci NMEN122586:GHGG-480-MONOMER.

Family and domain databases

Gene3Di 3.40.630.40. 2 hits.
InterProi IPR021731. AMIN_dom.
IPR002508. CW_Hdrlase/autolysin_cat.
[Graphical view ]
Pfami PF01520. Amidase_3. 1 hit.
PF11741. AMIN. 1 hit.
[Graphical view ]
SMARTi SM00646. Ami_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC58.
  2. "Characterization of the protein content of a meningococcal outer membrane vesicle vaccine by polyacrylamide gel electrophoresis and mass spectrometry."
    Vipond C., Wheeler J.X., Jones C., Feavers I.M., Suker J.
    Hum. Vaccin. 1:80-84(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Proteomic analysis of a meningococcal outer membrane vesicle vaccine prepared from the group B strain NZ98/254."
    Vipond C., Suker J., Jones C., Tang C., Feavers I.M., Wheeler J.X.
    Proteomics 6:3400-3413(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: NZ98/254 / Serogroup B.

Entry informationi

Entry nameiAMIC_NEIMB
AccessioniPrimary (citable) accession number: Q9K0V3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Present in outer membrane vesicle formulations which are used as vaccines in human.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3