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Q9K0V3

- AMIC_NEIMB

UniProt

Q9K0V3 - AMIC_NEIMB

Protein

N-acetylmuramoyl-L-alanine amidase AmiC

Gene

amiC

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Cell-wall hydrolase involved in septum cleavage during cell division.By similarity

    Catalytic activityi

    Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

    GO - Molecular functioni

    1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Cell wall biogenesis/degradation

    Enzyme and pathway databases

    BioCyciNMEN122586:GHGG-480-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetylmuramoyl-L-alanine amidase AmiC (EC:3.5.1.28)
    Gene namesi
    Name:amiC
    Ordered Locus Names:NMB0456
    OrganismiNeisseria meningitidis serogroup B (strain MC58)
    Taxonomic identifieri122586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000000425: Chromosome

    Subcellular locationi

    Periplasm By similarity

    GO - Cellular componenti

    1. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 416390N-acetylmuramoyl-L-alanine amidase AmiCPRO_0000320265Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi122586.NMB0456.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9K0V3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0860.
    HOGENOMiHOG000263827.
    KOiK01448.
    OMAiWMANKEN.
    OrthoDBiEOG6CP3X3.

    Family and domain databases

    Gene3Di3.40.630.40. 2 hits.
    InterProiIPR021731. AMIN_dom.
    IPR002508. CW_Hdrlase/autolysin_cat.
    [Graphical view]
    PfamiPF01520. Amidase_3. 1 hit.
    PF11741. AMIN. 1 hit.
    [Graphical view]
    SMARTiSM00646. Ami_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9K0V3-1 [UniParc]FASTAAdd to Basket

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    MIKLTRRQII RRTAGTLFAL SPIASAVAKT VRAPQFTAAR IWPSHTYTRL    50
    TLESTAALKY QHFTLDNPGR LVVDIQNANI NTVLHGLSQK VMADDPFIRS 100
    IRAGQNTPTT VRLVIDLKQP THAQVFALPP VGGFKNRLVV DLYPHGMDAD 150
    DPMMALLNGS LNKTLRGSPE ADLAQNTTPQ PGRGRNGRRP VIMLDPGHGG 200
    EDPGAISPGG LQEKHVVLSI ARETKNQLEA LGYNVFMTRN EDVFIPLGVR 250
    VAKGRARRAD VFVSIHADAF TSPSARGTGV YMLNTKGATS SAAKFLEQTQ 300
    NNADAVGGVP TSGNRNVDTA LLDMTQTATL RDSRKLGKLV LEELGRLNHL 350
    HKGRVDEANF AVLRAPDMPS ILVETAFLSN PAEEKLLGSE SFRRQCAQSI 400
    ASGVQRYINT SVLKRG 416
    Length:416
    Mass (Da):45,190
    Last modified:October 1, 2000 - v1
    Checksum:i5E89E0A60DE8AD21
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002098 Genomic DNA. Translation: AAF40893.1.
    PIRiB81198.
    RefSeqiNP_273503.1. NC_003112.2.

    Genome annotation databases

    EnsemblBacteriaiAAF40893; AAF40893; NMB0456.
    GeneIDi902572.
    KEGGinme:NMB0456.
    PATRICi20356126. VBINeiMen85645_0579.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002098 Genomic DNA. Translation: AAF40893.1 .
    PIRi B81198.
    RefSeqi NP_273503.1. NC_003112.2.

    3D structure databases

    ProteinModelPortali Q9K0V3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 122586.NMB0456.

    Protocols and materials databases

    DNASUi 902572.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF40893 ; AAF40893 ; NMB0456 .
    GeneIDi 902572.
    KEGGi nme:NMB0456.
    PATRICi 20356126. VBINeiMen85645_0579.

    Phylogenomic databases

    eggNOGi COG0860.
    HOGENOMi HOG000263827.
    KOi K01448.
    OMAi WMANKEN.
    OrthoDBi EOG6CP3X3.

    Enzyme and pathway databases

    BioCyci NMEN122586:GHGG-480-MONOMER.

    Family and domain databases

    Gene3Di 3.40.630.40. 2 hits.
    InterProi IPR021731. AMIN_dom.
    IPR002508. CW_Hdrlase/autolysin_cat.
    [Graphical view ]
    Pfami PF01520. Amidase_3. 1 hit.
    PF11741. AMIN. 1 hit.
    [Graphical view ]
    SMARTi SM00646. Ami_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MC58.
    2. "Characterization of the protein content of a meningococcal outer membrane vesicle vaccine by polyacrylamide gel electrophoresis and mass spectrometry."
      Vipond C., Wheeler J.X., Jones C., Feavers I.M., Suker J.
      Hum. Vaccin. 1:80-84(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. "Proteomic analysis of a meningococcal outer membrane vesicle vaccine prepared from the group B strain NZ98/254."
      Vipond C., Suker J., Jones C., Tang C., Feavers I.M., Wheeler J.X.
      Proteomics 6:3400-3413(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: NZ98/254 / Serogroup B.

    Entry informationi

    Entry nameiAMIC_NEIMB
    AccessioniPrimary (citable) accession number: Q9K0V3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present in outer membrane vesicle formulations which are used as vaccines in human.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3