Q9K0M5 (NQRC_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Na(+)-translocating NADH-quinone reductase subunit C
Short name=Na(+)-NQR subunit C
Short name=Na(+)-translocating NQR subunit C
EC=1.6.5.-

Alternative name(s):
NQR complex subunit C
NQR-1 subunit C

Gene names

Name:	nqrC
Ordered Locus Names:	NMB0567

Organism

Neisseria meningitidis serogroup B (strain MC58) [Reference proteome] [HAMAP]

Taxonomic identifier

122586 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria › Neisseria meningitidis › Neisseria meningitidis serogroup B

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na+ ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol By similarity. HAMAP-Rule MF_00427
Catalytic activity	NADH + ubiquinone + Na+(In) = NAD+ + ubiquinol + Na+(Out). HAMAP-Rule MF_00427
Cofactor	FMN By similarity.
Subunit structure	Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF By similarity.
Subcellular location	Cell inner membrane Potential HAMAP-Rule MF_00427.
Sequence similarities	Belongs to the NqrC family.
Caution	The residue potentially involved in the covalent binding of FMN is a Ser instead of a Thr.

Ontologies

Keywords
Biological process	Ion transport Sodium transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	FMN Flavoprotein NAD Sodium Ubiquinone
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sodium ion transport Inferred from electronic annotation. Source: HAMAP
Cellular_component	Gram-negative-bacterium-type cell wall Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	FMN binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	Na(+)-translocating NADH-quinone reductase subunit C HAMAP-Rule MF_00427		PRO_0000214218
Regions
	Transmembrane	13 – 35	23	Helical; Potential
Amino acid modifications
	Modified residue	226	1	FMN phosphoryl serine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9K0M5 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 1F20D8EF011F7C3E	FASTA	258	27,607
	10 20 30 40 50 60 MAKKFDKDSF SGTLIVVLAV SLICSVIVAG AVVGLKPIQE KQKLQDKQGY ILSVAGLMDK 70 80 90 100 110 120 DTDIGKTFAE RIEQRVVDLA TGEYVADAPK DFSARIAGKD PAQSIRIKTE DDLAGIKSRA 130 140 150 160 170 180 KYTEVYLVKG EDGKIGQIIL PMHGNGLWSV MYGFVAIQPD GNTINGITYY EQGETPGLGG 190 200 210 220 230 240 EIGNPLWQQK FVGKKLFDGQ GKLALHVGKG AGSDKEHGVD ALSGASLTSK GVQGSFAYWF 250 GENGYIPYLN KLKSAGAQ

References

[1]

"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58." Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O. , Fleischmann R.D., Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., Venter J.C. Science 287:1809-1815(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC58.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE002098 Genomic DNA. Translation: AAF40995.1.
PIR	B81185.
RefSeq	NP_273611.1. NC_003112.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	122586.NMB0567.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAF40995; AAF40995; NMB0567.
GeneID	902682.
KEGG	nme:NMB0567.
PATRIC	20356413. VBINeiMen85645_0726.
Phylogenomic databases
eggNOG	COG2869.
HOGENOM	HOG000273678.
KO	K00348.
OMA	KGYGLWS.
ProtClustDB	PRK05346.
Enzyme and pathway databases
BioCyc	NMEN122586:GHGG-568-MONOMER.
Family and domain databases
HAMAP	MF_00427. NqrC.
InterPro	IPR007329. FMN-bd. IPR010204. NADH_UbQ_OxRdtase_suC. [Graphical view]
Pfam	PF04205. FMN_bind. 1 hit. [Graphical view]
PIRSF	PIRSF009437. NQR-1_subunit_C. 1 hit.
SMART	SM00900. FMN_bind. 1 hit. [Graphical view]
TIGRFAMs	TIGR01938. nqrC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NQRC_NEIMB

Accession

Primary (citable) accession number: Q9K0M5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program