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Protein

Na(+)-translocating NADH-quinone reductase subunit C

Gene

nqrC

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na+ ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.UniRule annotation

Catalytic activityi

NADH + ubiquinone + n Na+(In) = NAD+ + ubiquinol + n Na+(Out).UniRule annotation

Cofactori

FMNUniRule annotation

GO - Molecular functioni

  1. FMN binding Source: UniProtKB-HAMAP
  2. oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor Source: UniProtKB-HAMAP

GO - Biological processi

  1. sodium ion transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Flavoprotein, FMN, NAD, Sodium, Ubiquinone

Enzyme and pathway databases

BioCyciNMEN122586:GHGG-593-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)-translocating NADH-quinone reductase subunit CUniRule annotation (EC:1.6.5.8UniRule annotation)
Short name:
Na(+)-NQR subunit CUniRule annotation
Short name:
Na(+)-translocating NQR subunit CUniRule annotation
Alternative name(s):
NQR complex subunit CUniRule annotation
NQR-1 subunit CUniRule annotation
Gene namesi
Name:nqrCUniRule annotation
Ordered Locus Names:NMB0567
OrganismiNeisseria meningitidis serogroup B (strain MC58)
Taxonomic identifieri122586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000000425 Componenti: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. Gram-negative-bacterium-type cell wall Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Na(+)-translocating NADH-quinone reductase subunit CPRO_0000214218Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei226 – 2261FMN phosphoryl serineUniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.UniRule annotation

Protein-protein interaction databases

STRINGi122586.NMB0567.

Family & Domainsi

Sequence similaritiesi

Belongs to the NqrC family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2869.
HOGENOMiHOG000273678.
KOiK00348.
OMAiKGYGLWS.
OrthoDBiEOG6F2981.

Family and domain databases

HAMAPiMF_00427. NqrC.
InterProiIPR007329. FMN-bd.
IPR010204. NADH_UbQ_OxRdtase_suC.
[Graphical view]
PfamiPF04205. FMN_bind. 1 hit.
[Graphical view]
PIRSFiPIRSF009437. NQR-1_subunit_C. 1 hit.
SMARTiSM00900. FMN_bind. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01938. nqrC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9K0M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKFDKDSF SGTLIVVLAV SLICSVIVAG AVVGLKPIQE KQKLQDKQGY
60 70 80 90 100
ILSVAGLMDK DTDIGKTFAE RIEQRVVDLA TGEYVADAPK DFSARIAGKD
110 120 130 140 150
PAQSIRIKTE DDLAGIKSRA KYTEVYLVKG EDGKIGQIIL PMHGNGLWSV
160 170 180 190 200
MYGFVAIQPD GNTINGITYY EQGETPGLGG EIGNPLWQQK FVGKKLFDGQ
210 220 230 240 250
GKLALHVGKG AGSDKEHGVD ALSGASLTSK GVQGSFAYWF GENGYIPYLN

KLKSAGAQ
Length:258
Mass (Da):27,607
Last modified:September 30, 2000 - v1
Checksum:i1F20D8EF011F7C3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002098 Genomic DNA. Translation: AAF40995.1.
PIRiB81185.
RefSeqiNP_273611.1. NC_003112.2.

Genome annotation databases

EnsemblBacteriaiAAF40995; AAF40995; NMB0567.
GeneIDi902682.
KEGGinme:NMB0567.
PATRICi20356413. VBINeiMen85645_0726.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002098 Genomic DNA. Translation: AAF40995.1.
PIRiB81185.
RefSeqiNP_273611.1. NC_003112.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi122586.NMB0567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF40995; AAF40995; NMB0567.
GeneIDi902682.
KEGGinme:NMB0567.
PATRICi20356413. VBINeiMen85645_0726.

Phylogenomic databases

eggNOGiCOG2869.
HOGENOMiHOG000273678.
KOiK00348.
OMAiKGYGLWS.
OrthoDBiEOG6F2981.

Enzyme and pathway databases

BioCyciNMEN122586:GHGG-593-MONOMER.

Family and domain databases

HAMAPiMF_00427. NqrC.
InterProiIPR007329. FMN-bd.
IPR010204. NADH_UbQ_OxRdtase_suC.
[Graphical view]
PfamiPF04205. FMN_bind. 1 hit.
[Graphical view]
PIRSFiPIRSF009437. NQR-1_subunit_C. 1 hit.
SMARTiSM00900. FMN_bind. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01938. nqrC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC58.

Entry informationi

Entry nameiNQRC_NEIMB
AccessioniPrimary (citable) accession number: Q9K0M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2001
Last sequence update: September 30, 2000
Last modified: March 3, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

The residue potentially involved in the covalent binding of FMN is a Ser instead of a Thr.UniRule annotationCurated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.